Insights into the Uses of Traditional Plants for Diabetes Nephropathy: A Review

H., Haleema Shahin D.; Sultana, Rokeya; Farooq, Juveriya; Taj, Tahreen; Khaiser, Umaima Farheen; Alanazi, Nader Sulaiman Ayyt; Alshammari, Mohammed Kanan; Alshammari, Mohammad Nazal; Alsubaie, Firas Hamdan; Asdaq, Syed Mohammed Basheeruddin; Alotaibi, Abdulmueen A.; Alamir, Abdulrhman ahmed; Imran, Mohd; Jomah, Shahamah

doi:10.3390/cimb44070199

Cited by 20 publications

(15 citation statements)

References 88 publications

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“…Scientific reports have proven the pharmacological effects of ginger as antibacterial, anticancer, antioxidant, antidiabetic, analgesic, and anti-inflammatory activities [29,31,32]. In addition to helping treat and prevent arthritis, it has hepatoprotective and nephroprotective effects [33][34][35]. The propensity of ginger extract to facilitate the synthesis of metal nanoparticles was previously reported for copper [36], silver [37], and gold [38].…”

Section: Introductionmentioning

confidence: 92%

Green Synthesis of Gold Nanoparticles by Aqueous Extract of Zingiber officinale: Characterization and Insight into Antimicrobial, Antioxidant, and In Vitro Cytotoxic Activities

Fouda

Eid

Guibal³

et al. 2022

Applied Sciences

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The main challenge for researchers in the biomedical sectors concerns the development of new active compounds through cost-effectiveness, rapid, simple, and ecofriendly methods to overcome antibiotic resistance to pathogenic microbes. Herein, gold nanoparticles (AuNPs) were fabricated by a green approach through the reduction of chloroauric acid (HAuCl4) by harnessing the metabolites present in the aqueous extract of Zingiber officinale rhizome. UV-Vis spectroscopy, FT-IR, XRD, TEM, DLS, and zeta potential were used to characterize phytosynthesized AuNPs. In addition, the antimicrobial effect was investigated against Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus), Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), unicellular fungi (Candida albicans), and multicellular fungi (Aspergillus brasiliensis). Antioxidant and in vitro cytotoxic activities were assessed. TEM and XRD showed the successful formation of spherical and crystalline structures, with sizes in the range of 5–53 nm (average size: 15.11 ± 8.5 nm). The zeta potential value (i.e., –28.8 mV) explains the high stability of synthesized AuNPs. AuNPs exhibit promising activity against prokaryotic and eukaryotic microorganisms with variable inhibition zones and low MIC values in the range of 25–6.25 µg mL−1. Phytosynthesized AuNPs exhibit DPPH scavenging activity with percentages of 87.6 ± 0.5% at a maximum concentration (1000 µg mL−1), which can be compared with ascorbic acid (97.3 ± 0.2%). Moreover, the AuNPs displayed a target-oriented effect for cancer cell lines HepG2 and MCF7 at low IC50 concentrations of 131.9 ± 9.34 and 288.23 ± 31.39 µg mL−1 compared to the normal oral epithelial OEC cell line (487.612 ± 3.53 µg mL−1). Overall, the phytosynthesized AuNPs show wide activities that enable their use in various biomedical and biotechnological applications.

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Section: Introductionmentioning

confidence: 92%

Green Synthesis of Gold Nanoparticles by Aqueous Extract of Zingiber officinale: Characterization and Insight into Antimicrobial, Antioxidant, and In Vitro Cytotoxic Activities

Fouda

Eid

Guibal³

et al. 2022

Applied Sciences

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“…Diabetes nephropathy is common renal disease associated with long terms of diabetes mellitus. Its complications include proteinuria, reduction in glomerular filtration, glomerular enlargement, and renal fibrosis [28]. In some certain regions, the prevalence of diabetes nephropathy in adults was recorded over 20% [29].…”

Section: Diabetic Nephropathymentioning

confidence: 99%

LRG1 Contributes to the Pathogenesis of Multiple Kidney Diseases: A Comprehensive Review

Chen,

Zhang,

et al. 2024

Kidney Dis

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Background: The increasing prevalence of kidney diseases has become a significant public health issue, with a global prevalence exceeding 10%. In order to accurately identify biochemical changes and treatment outcomes associated with kidney diseases, novel methods targeting specific genes have been discovered. Among these genes, leucine-rich α-2 glycoprotein 1 (LRG1) has been identified to function as a multifunctional pathogenic signaling molecule in multiple diseases, including kidney diseases. This study aims to provide a comprehensive overview of the current evidence regarding the roles of LRG1 in different types of kidney diseases. Summary: Based on a comprehensive review, it was found that LRG1 was up-regulated in the urine, serum, or renal tissues of patients or experimental animal models with multiple kidney diseases, such as diabetic nephropathy, kidney injury, IgA nephropathy, chronic kidney diseases (CKD), clear cell renal cell carcinoma (ccRCC), end-stage renal disease, canine leishmaniosis-induced kidney disease, kidney fibrosis, and aristolochic acid nephropathy. Mechanistically, the role of LRG1 in kidney diseases is believed to be detrimental, potentially through its regulation of various genes and signaling cascades, i.e. FN1, GPR56, VEGF, VEGFR-2, DR5, GDF15, HIF-1α, SPP1, ALK1-Smad1/5/8, NLRP3-IL-1b, and TGF-β pathway. Key Messages: Further research is needed to fully comprehend the molecular mechanisms by which LRG1 contributes to the pathogenesis and pathophysiology of kidney diseases. It is anticipated that targeted treatments focusing on LRG1 will be utilized in clinical trials and implemented in clinical practice in the future.

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“…Thus, the most effective and simple way to prevent these complications seems to be restoring postprandial blood glucose levels to normal levels within several hours after each meal. Biofactors derived from edible sources such as phytochemicals and zoochemicals [4][5][6][7] seem to be excellent candidates from the viewpoint of safety, as well as their antihyperglycemic effect, because they have a long history of ingestion.…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic Effect of Urolithin A in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Glucose Intolerance

Kondo,

Adachi,

Komatsu

et al. 2024

CIMB

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Diabetes is caused by abnormal glucose metabolism, and muscle, the largest tissue in the human body, is largely involved. Urolithin A (UroA) is a major intestinal and microbial metabolite of ellagic acid and ellagitannins and is found in fruits such as strawberry and pomegranate. In this present study, we investigated the antidiabetic effects of UroA in L6 myotubes and in KK-Ay/Ta, a mouse model of type 2 diabetes (T2D). UroA treatment elevated the glucose uptake (GU) of L6 myotubes in the absence of insulin. This elevation in GU by UroA treatment was partially inhibited by the concurrent addition of LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K) which activates Akt (PKB: protein kinase B) or Compound C, an inhibitor of 5′-adenosine monophosphate-activated protein kinase (AMPK). Moreover, UroA was found to activate both pathways of Akt and AMPK, and then to promote translocation of glucose transporter 4 (GLUT4) from the cytosol to the plasma membrane in L6 myotubes. Based on these in vitro findings, an intraperitoneal glucose tolerance test (IPGTT) was performed after the oral administration of UroA for 3 weeks to KK-Ay/Ta mice with glucose intolerance. UroA was demonstrated to alleviate glucose intolerance. These results suggest that UroA is a biofactor with antihyperglycemic effects in the T2D state.

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Insights into the Uses of Traditional Plants for Diabetes Nephropathy: A Review

Cited by 20 publications

References 88 publications

Green Synthesis of Gold Nanoparticles by Aqueous Extract of Zingiber officinale: Characterization and Insight into Antimicrobial, Antioxidant, and In Vitro Cytotoxic Activities

Green Synthesis of Gold Nanoparticles by Aqueous Extract of Zingiber officinale: Characterization and Insight into Antimicrobial, Antioxidant, and In Vitro Cytotoxic Activities

LRG1 Contributes to the Pathogenesis of Multiple Kidney Diseases: A Comprehensive Review

Antidiabetic Effect of Urolithin A in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Glucose Intolerance

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