Insights of Antioxidants as Molecules for Drug Discovery

Baunthiyal, Mamta; Singh, V. P.; Dwivedi, S. K.

doi:10.3923/ijp.2017.874.889

Cited by 28 publications

(23 citation statements)

References 108 publications

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“…Such enzymatic and nonenzymatic antioxidants act by dismutating, detoxifying and producing less and/or non-reactive species. Although the biological defense provided by CAT, GPx, SOD, and their related molecules against oxidative stress can keep oxidative balance in check, additional consumption of antioxidants, known as exogenous antioxidants, can prevent oxidative damage when oxidants overcome this antioxidant defense (Baunthiyal, Singh, & Dwivedi, 2017;Bouayed & Bohn, 2010).…”

Section: Biological Effectsmentioning

confidence: 99%

Bioactive peptides as natural antioxidants in food products – A review

Lorenzo

Munekata

Gómez

et al. 2018

Trends in Food Science & Technology

388

199

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Background: Over the last years, bioactive antioxidant peptides, extracted from food proteins, have been studied due to their potential as useful tools in the development of new natural drugs and food ingredients. These compounds can be used to decrease oxidative stress and food quality decay, thus being an interesting strategy to reduce economic losses in food production, as well as improve public health. Scope and Approach: Antioxidant peptides are extracted from non-antioxidant precursor proteins from different origin by the activity of either proteolytic microorganisms or isolated enzymes. In the present review, the main sources of bioactive peptides will be discussed. Moreover, the current strategies to obtain these compounds as well as their health benefits and in vivo biological effects will be evaluated. Considerations for further research and development of strategies to increase the knowledge about this underexplored activity of peptides will be also considered.

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Section: Biological Effectsmentioning

confidence: 99%

Bioactive peptides as natural antioxidants in food products – A review

Lorenzo

Munekata

Gómez

et al. 2018

Trends in Food Science & Technology

388

199

View full text Add to dashboard Cite

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“…Reactive oxygen species (ROS) is indispensable in many biological processes, mainly during cell differentiation, defense mechanism, immunity, etc. (Baunthiyal et al, 2017), therefore ROS is produced in normal metabolic reaction (endogenous ROS) and is maintained at physiological levels by several endogenous antioxidant systems. In addition, exogenous ROS may be generated from environmental pollutants, excessive alcohol consumption, radiations exposure, viral and bacterial infections, and others (Cacciapuoti, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Antioxidants supplied in a diet are needed to counter the undesirable effects of oxidative stress by various mechanisms such as scavenging the active free radicals, depressing the active eISSN: 2550-2166 © 2019 The Authors. Published by Rynnye Lyan Resources species formation, sequestering metal ion, inducing biosynthesis and enhancing the activity of endogenous antioxidant, repairing damaged molecules and cleaning (Baunthiyal et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activities of methanolic extract and its fractions of Baccaurea racemosa and Macaranga subpeltata leaves

Widodo¹,

Sismindari²,

Asmara³

et al. 2019

Food Res.

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Oxidative stress, the excessive presence of reactive oxygen species (ROS), is suggested as a basal cause of aging as well as various degenerative and chronic diseases in human. Antioxidants are believed to play a very vital role in the body defense system against ROS. Plant-based antioxidants with their prominence have gained tremendous worldwide interest nowadays. Baccaurea racemosa and Macaraanga subpeltata are among ethnomedical used plants for liver diseases medication which have potential source as natural antioxidants. The aim of the study was to evaluate the antioxidant activities of the methanolic crude extract (CE) and their fractions of the plant’s leaves. Maceration was performed to obtain CE, which then subjected to fractionation using n-hexane, dichloromethane, chloroform, ethyl acetate, and ethanol to obtain fractions of hexane fraction (HF), dichloromethane (DF), chloroform (CF), ethyl acetate (EAF), and ethanol fractions (EF), respectively. The CE and all fractions included water fraction (WF) and residue (R) were examined for its total phenolic contents, total flavonoid contents, and antioxidant activities using various in vitro assay. In general, EAF demonstrated as the best solvent for the extracting phenolic compounds with higher antioxidant activity. The CE and its fractions of M. subpeltata contained higher of TPC and TFC, also demonstrated higher antioxidant capacity, than that B. racemosa. The phenolics compounds were responsible for the antiradical properties. The EAF of M. subpeltata was scavenging those radicals better than that of L-(+)ascorbic acid as a positive control. The high antioxidant activities and phenolics contents make both the plant extracts to be developed as a food supplement.

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“…Oxidative stress has been the underlying mechanism behind the aetiology of many human diseases [10]. Several antioxidants including vitamin E have been tested for their ability to fight oxidative stress [11].…”

Section: Introductionmentioning

confidence: 99%

The Hepatotoxic Effect of Sildenafil Citrate and Its Combination with Tramadol on Male Wistar Rats is Ameliorated with Vitamin E Supplementation

Nwangwa

Udefa

M.³

et al. 2019

ACRI

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Aims: This study investigated the effect of vitamin E on serum liver enzymes and bilirubin concentrations in male Wistar rats treated with sildenafil citrate (SC) and a combination of SC and tramadol on the background that these drugs cause oxidative damage to the liver. Methods: Thirty male Wistar rats (180-200 g) were randomly divided into six groups (n=5) thus: control (0.2 ml vehicle – olive oil), SC-treated group (Sil) (10 mg/kg of SC), SC+tramadol-treated group (Sil+Tra) (10 mg/kg of SC and 20 mg/kg of tramadol), vitamin E-treated group (Vit E) (100mg/kg of vitamin E), SC+vitamin E-treated group (Sil+Vit E) (received SC and vitamin E) and SC+tramadol+vitamin E-treated group (Sil+Tra+Vit E) (received SC, tramadol and vitamin E). Drugs were administered orally once daily for four weeks after which blood samples were obtained and used to measure serum concentrations of liver enzymes (AST, ALT and ALP) and bilirubin. Results: Serum AST, ALT, ALP, total bilirubin (TB) and unconjugated bilirubin (UCB) concentrations were significantly (p<0.001) increased in Sil and Sil+Tra compared with control and Vit E and significantly (p<0.01) decreased in Sil+Vit E and Sil+Tra+Vit E compared with Sil and Sil+Tra. Serum conjugated bilirubin (CB) concentration and percentage conjugation of bilirubin significantly decreased (p<0.001) in Sil and Sil+Tra compared with control and Vit E and increased (p<0.01) in Sil+Vit E and Sil+Tra+Vit E compared with Sil and Sil+Tra. Conclusion: SC, administered separately and in combination with tramadol altered liver function. However, vitamin E supplementation was able to ameliorate this alteration in liver function.

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Insights of Antioxidants as Molecules for Drug Discovery

Cited by 28 publications

References 108 publications

Bioactive peptides as natural antioxidants in food products – A review

Bioactive peptides as natural antioxidants in food products – A review

Antioxidant activities of methanolic extract and its fractions of Baccaurea racemosa and Macaranga subpeltata leaves

The Hepatotoxic Effect of Sildenafil Citrate and Its Combination with Tramadol on Male Wistar Rats is Ameliorated with Vitamin E Supplementation

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