Insights of hypercarotenaemia: A brief review

Priyadarshani, A.M.B.

doi:10.1016/j.clnesp.2017.12.002

Cited by 22 publications

(15 citation statements)

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“…Scientists believed that a combination of an elevated intake of low-calorie foods rich on carotenoids such as carrots and spinach, a reduced metabolic conversion to vitamin A, and a reduced carotenoid deposition in adipose tissue could lead to hypercarotenemia [130,131]. In agreement with this hypothesis, patients suffering cachexia do not show signs of hypercarotenemia, although they present a reduced adipose tissue size, [132]. More research on this topic will be necessary to elucidate these interesting observations, as carotenoids could play a role on anorexia nervosa [132], or as carotenoids could worsen this disorder as some of them have leaning effects as they favor fatty acid oxidation via retinoic acid signaling.…”

Section: β-Carotene and Obesity; Key Findings And Technical Limitamentioning

confidence: 99%

β-carotene in Obesity Research: Technical Considerations and Current Status of the Field

2019

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Over the past decades, obesity has become a rising health problem as the accessibility to high calorie, low nutritional value food has increased. Research shows that some bioactive components in fruits and vegetables, such as carotenoids, could contribute to the prevention and treatment of obesity. Some of these carotenoids are responsible for vitamin A production, a hormone-like vitamin with pleiotropic effects in mammals. Among these effects, vitamin A is a potent regulator of adipose tissue development, and is therefore important for obesity. This review focuses on the role of the provitamin A carotenoid β-carotene in human health, emphasizing the mechanisms by which this compound and its derivatives regulate adipocyte biology. It also discusses the physiological relevance of carotenoid accumulation, the implication of the carotenoid-cleaving enzymes, and the technical difficulties and considerations researchers must take when working with these bioactive molecules. Thanks to the broad spectrum of functions carotenoids have in modern nutrition and health, it is necessary to understand their benefits regarding to metabolic diseases such as obesity in order to evaluate their applicability to the medical and pharmaceutical fields.

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Section: β-Carotene and Obesity; Key Findings And Technical Limitamentioning

confidence: 99%

β-carotene in Obesity Research: Technical Considerations and Current Status of the Field

2019

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“…A deficiency in thyroid hormone leads to a hypometabolic state impacting the availability of energy . Furthermore, hypercarotenemia can arise in patients with hypothyroidism without an excessive intake of carotenoid …”

Section: Vitamin A: Hormone‐like Effectmentioning

confidence: 99%

Vitamin A and Wound Healing

et al. 2019

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Vitamin A is a general term for retinoids. Vitamin A deficiency leads to a variety of cutaneous manifestations. It also functions as a hormone through retinoic acid receptors altering the activity of multiple cell lines. Pancreatic vitamin A levels are critical for retinoid signaling and normal pancreatic control of glucose. Vitamin A deficiency is more common during infection, and supplementation reduces severe morbidity and mortality from infectious diseases. Vitamin A modulates activities at the cellular level and, via its interrelationship with hormones such as thyroid, insulin, and corticosteroids, has diffuse metabolic effects on the body. It plays an important role in all stages of wound healing. Vitamin A is known for its ability to stimulate epithelial growth, fibroblasts, granulation tissue, angiogenesis, collagen synthesis, epithelialization, and fibroplasia. Local (topical) and systemic supplementation with vitamin A has been proven to increase dermal collagen deposition. There are numerous animal studies and limited human studies regarding physiologic effect of vitamin A on acute or chronic wounds via systemic or topical administration. The most common use of vitamin A supplementation is to offset steroids' effect. When considering supplementation, the potential benefits must be weighed against the risk of harm. Vitamin A toxicity can be critical and even result in death. The evidence for supplementation with vitamin A is currently limited to expert opinion and is not backed up by rigorous trials. There is an acute need for therapeutic trials with vitamin A supplementations. (Nutr Clin Pract. 2019;34:839-849)

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“…Carotenoderma is a yellowish discoloration of the skin especially of the palms, soles, and central face which is sometimes seen in diabetic patients and patients with trisomy 21 [1]. It is more common in children and is not associated with the ingestion of carrots.…”

Section: Sirmentioning

confidence: 99%