Insights on the Association between Thyroid Diseases and Colorectal Cancer

Gagliardi, Federica; Baldini, Enke; Lori, Eleonora; Cardarelli, Silvia; Pironi, Daniele; Lauro, Augusto; Tripodi, Domenico; Palumbo, Piergaspare; D’Armiento, Eleonora; Cavallaro, Giuseppe; Polistena, Andrea; D’Orazi, Valerio; Sibio, Simone; Fallahi, Poupak; Antonelli, Alessandro; D’Andrea, Vito; Ulisse, Salvatore; Sorrenti, Salvatore

doi:10.3390/jcm12062234

Cited by 5 publications

(3 citation statements)

References 118 publications

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“…For instance, L'Heureux conducted a case-control study in Taiwan including 69,713 CRC patients and 69,713 controls. It showed a 22% lower risk of CRC in people with hypothyroidism with an adjusted OR of 0.78 [30,31] . Another study by Mondul et al observed that people with hypothyroidism were at decreased risk of prostate cancer compared to men with normal thyroid function [32,33] .…”

Section: Discussionmentioning

confidence: 97%

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Causal Associations of Hypothyroidism with Prostate Cancer, Colorectal Cancer and Lung Cancer: A Mendelian Randomization Study

2023

medsc

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Previous observational studies have suggested that hypothyroidism may affect the risk of cancer. However, the causal effects were still unclear and controversary. Therefore, a two-sample Mendelian randomization (MR) analysis was conducted to evaluate the association between hypothyroidism and six types of cancer, including colorectum, pancreas, prostate, lung, bladder and stomach cancer. The inverse variance weighted (IVW), MR-Egger and Weighted Media were carried out to estimate the relation in the MR analysis. Different approaches such as leave-one-out analysis and MR-PRESSO for sensitivity analyses were used to assess the stability of the results. The MR results showed that hypothyroidism was causally associated with decreased risk of lung cancer (OR [odds ratio] = 0.19, P= 0.007), colorectal cancer (OR = 0.27, P= 0.016) and prostate cancer (OR = 0.18, P= 7.44e-05). Significant association between hypothyroidism and the risk of bladder cancer, stomach cancer and pancreas were not found with IVW P>0.05. These results indicated that hypothyroidism can decrease the risk of lung cancer, colorectal cancer and prostate cancer. But evidence of the association between hypothyroidism and other three types of cancer was not found in our study. Further research is necessary to clarify the relation.

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Section: Discussionmentioning

confidence: 97%

“…Another study by Mondul et al observed that people with hypothyroidism were at decreased risk of prostate cancer compared to men with normal thyroid function [32,33] . However, there were studies that conflicted with the association [10,30,34] .…”

Section: Discussionmentioning

confidence: 99%

Causal Associations of Hypothyroidism with Prostate Cancer, Colorectal Cancer and Lung Cancer: A Mendelian Randomization Study

2023

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“…Although some studies have suggested that breast and thyroid cancers are clinically related to estrogen, a direct cause remains unknown [ 22 ]. Instead, estrogen influences cellular functions by binding to nuclear receptors identified as estrogen receptors alpha and beta (ERα and Erβ, respectively) [ 23 ]. The expression of ERs, particularly ERα is involved in the development of thyroid cancer in patients with breast cancer [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

The Role of Blood Microbiome in the Development of Thyroid Cancer in Breast Cancer Survivors

An,

Kwon,

Kim

2023

Cancers

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Patients diagnosed with breast cancer are likely to be diagnosed with thyroid cancer as a second primary cancer. Similarly, patients with thyroid cancer are likely to develop breast cancer. In this study, we found an association between these two types of cancers in the microbiomes of patients with breast cancer. Blood samples were collected from 96 patients with breast cancer, their bacterial extracellular vesicles were isolated, and their microbiomes were analyzed. After microbiome analysis, researchers performed thyroid function tests, estrogen levels, and thyroid ultrasound results of these patients, and the relationships among these parameters were analyzed. Based on the thyroid ultrasonography results, differences in the microbiome were confirmed in the normal, cyst, nodule, and thyroid lobectomy groups. We investigated the microbiome differences between normal thyroid and thyroid cancer. In particular, the abundance of the genus Bacillus is related to estrogen levels, which could affect thyroid abnormalities and increase thyroid-stimulating hormone levels. This study explains the causes of thyroid cancer in patients with breast cancer using microbiomes and serological tests for thyroid hormones and estrogen. These can be used as basic data for preventing thyroid cancer in patients with breast cancer.

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Prevalence and implications of pKs-positive Escherichia coli in colorectal cancer

de Souza,

de Almeida Campos,

Palácio

et al. 2024

Life Sciences

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Insights on the Association between Thyroid Diseases and Colorectal Cancer

Cited by 5 publications

References 118 publications

Causal Associations of Hypothyroidism with Prostate Cancer, Colorectal Cancer and Lung Cancer: A Mendelian Randomization Study

Causal Associations of Hypothyroidism with Prostate Cancer, Colorectal Cancer and Lung Cancer: A Mendelian Randomization Study

The Role of Blood Microbiome in the Development of Thyroid Cancer in Breast Cancer Survivors

Prevalence and implications of pKs-positive Escherichia coli in colorectal cancer

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