Insights on the Multifunctional Activities of Magnolol

Zhang, Jianhong; Chen, Zhixi; Huang, Xianhua; Shi, Weimei; Zhang, Rui; Chen, Mei‐Ling; Huang, Hao; Wu, Longhuo

doi:10.1155/2019/1847130

Cited by 56 publications

(62 citation statements)

References 119 publications

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“…Polyphenols, such as thymoquinone [ 16 , 17 ], resveratrol [ 18 ], and pomegranate [ 19 ], have been reported to increase antioxidant capacities and HO-1 expression to regulate hepatic steatosis and inflammation [ 20 ]. Magnolol (MG) is the main bioactive compound derived from Magnolia officinalis , which has been shown to exert anti-inflammation, anti-oxidation, and hepatoprotective properties [ 21 , 22 ]. MG reduced inflammation through inhibition of nuclear factor-kappa B (NF-κB) activation in TNF-α-stimulated human aortic endothelial cells [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Involvement of HO-1 and Autophagy in the Protective Effect of Magnolol in Hepatic Steatosis-Induced NLRP3 Inflammasome Activation In Vivo and In Vitro

et al. 2020

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Magnolol (MG) is the main active compound of Magnolia officinalis and exerts a wide range of biological activities. In this study, we investigated the effects of MG using tyloxapol (Tylo)-induced (200 mg/kg, i.p.) hyperlipidemia in rats and palmitic acid (PA)-stimulated (0.3 mM) HepG2 cells. Our results showed that Tylo injection significantly increased plasma levels of triglyceride and cholesterol as well as superoxide anion in the livers, whereas MG pretreatment reversed these changes. MG reduced hepatic lipogenesis by attenuating sterol regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase (FAS) proteins and Srebp-1, Fas, Acc, and Cd36 mRNA expression as well as upregulated the lipolysis-associated genes Hsl, Mgl, and Atgl. Furthermore, MG reduced plasma interleukin-1β (IL-1β) and protein expression of NLR family pyrin domain-containing 3 (NLRP3), apoptosis-associated speck-like protein (ASC), and caspase 1 as well as upregulated nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and induction of heme oxygenase-1 (HO-1) in hepatocytes of Tylo-treated rats. Enhanced autophagic flux by elevation of autophagy related protein 5-12 (ATG5-12), ATG7, Beclin1, and microtubule-associated protein light chain 3 B II (LC3BII)/LC3BI ratio, and reduction of sequestosome-1 (SQSTM1/p62) and phosphorylation of mTOR was observed by MG administration. However, autophagy inhibition with 3-methyladenine (3-MA) in HepG2 cells drastically abrogated the MG-mediated suppression of inflammation and lipid metabolism. In conclusion, MG inhibited hepatic steatosis-induced NLRP3 inflammasome activation through the restoration of autophagy to promote HO-1 signaling capable of ameliorating oxidative stress and inflammatory responses.

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Section: Introductionmentioning

confidence: 99%

Involvement of HO-1 and Autophagy in the Protective Effect of Magnolol in Hepatic Steatosis-Induced NLRP3 Inflammasome Activation In Vivo and In Vitro

et al. 2020

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“…One hydroxyl group of the first magnolol molecule forms a hydrogen bond with Ser-289 of PPARγ and hydrogen bonds with Tyr-473, while another hydroxyl group of the second magnolol molecule forms a hydrogen bond with Ser-342 with additional hydrogen bonding. Downstream pathways that have been identified following magnolol/honokiol binding to their cognate receptors include the NF-κB/MAPK, Nrf2/HO-1, and PI3K/Akt signaling cascades (30). Base on the aforementioned statement, the intestinal biochemicals in the current study might stimulate host intestinal epithelial and/or immune cells receptors.…”

Section: Discussionmentioning

confidence: 97%

Dietary Supplementation With Magnolia Bark Extract Alters Chicken Intestinal Metabolite Levels

Park

Lillehoj

et al. 2020

Front. Vet. Sci.

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Magnolia bark extract administered as a dietary supplement to poultry confers a performance and health benefit, but the mechanisms are unknown. Here, a metabolomics approach was used to identify changes in intestinal metabolite levels in chickens fed an unsupplemented diet or a diet supplemented with magnolia bark extract. Total body weight gains of chickens fed magnolia bark-supplemented diets were increased 2% (from 861 to 878 g/chicken), compared with chickens fed an unsupplemented diet. Compared with unsupplemented controls, the levels of 278 intestinal biochemicals (metabolites) were altered (165 increased, 113 decreased) in chickens given the magnolia-supplemented diet. Data for biochemicals of intestinal contents of chickens fed the unsupplemented diet clustered on the left side of the PCA score plot, while those of the magnolia-supplemented diet were separated and clustered on the right side. The biochemicals included changes in the levels of amino acids, fatty acids, peptides, and nucleosides, which provided a distinctive biochemical signature unique to the magnolia-supplemented group, compared with the unsupplemented group. These results provide the foundation for future studies to identify naturally-produced biochemicals that might be used to improve poultry growth performance.

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“…The sample preparation, extract analysis, metabolite identification and quantification were conducted as previously fully described by Zhang et al [25].…”

Section: Extraction Of Samples Metabolitesmentioning

confidence: 99%

“…Therefore, we compared the metabolite contents in the two genotypes under control condition. The differentially accumulated metabolites (DAM) were selected based on the variable importance in projection (VIP) ≥ 1 and fold change ≥ 2 or fold change ≤ 0.5 [25]. As suspected, we detected 195 DAMs between the two genotypes with 123 up-accumulated and 72 down-accumulated in the tolerant genotype ( Table S2).…”

Section: Comparison Of Metabolite Contents Between Z0284 and Lszqk Unmentioning

confidence: 99%

Insights into the metabolic responses of two contrasting Tibetan hulless barley genotypes under low nitrogen stress

Sang¹,

Yang²,

Yuan³

et al. 2019

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Nitrogen (N) is an essential macronutrient for plants. However, excessive use of N fertilizer for cultivation is an environmental hazard. A good adaption to N deficiency is known in the Tibetan hulless barley. Therefore, it is of interest to complete the metabolic analysis on LSZQK which is a low nitrogen (low-N) sensitive genotype and Z0284 that is tolerant to low-N. We identified and quantified 750 diverse metabolites in this analysis. The two genotypes show differences in their basal metabolome under normal N condition. Polyphenols and lipids related metabolites were significantly enriched in Z0284 having a basal role prior to exposure to low-N stress. Analysis of the differentially accumulated metabolites (DAM) induced by low-N explain the genotype-specific responses. Fourteen DAMs showed similar patterns of change between low-N and control conditions in both genotypes. This could be the core low-N responsive metabolites regardless of the tolerance level in hulless barley. We also identified 4 DAMs (serotonin, MAG (18:4) isomer 2, tricin 7-O-feruloylhexoside and gluconic acid) shared by both genotypes displaying opposite patterns of regulation under low-N conditions and may play important roles in low-N tolerance. This report provides a theoretical basis for further understanding of the molecular mechanisms of low-N stress tolerance in hulless barley.

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Insights on the Multifunctional Activities of Magnolol

Cited by 56 publications

References 119 publications

Involvement of HO-1 and Autophagy in the Protective Effect of Magnolol in Hepatic Steatosis-Induced NLRP3 Inflammasome Activation In Vivo and In Vitro

Involvement of HO-1 and Autophagy in the Protective Effect of Magnolol in Hepatic Steatosis-Induced NLRP3 Inflammasome Activation In Vivo and In Vitro

Dietary Supplementation With Magnolia Bark Extract Alters Chicken Intestinal Metabolite Levels

Insights into the metabolic responses of two contrasting Tibetan hulless barley genotypes under low nitrogen stress

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