Insights on the role of l-lactate as a signaling molecule in skin aging

Chirumbolo, Salvatore; Bertossi, Dario; Magistretti, Pierre J.

doi:10.1007/s10522-023-10018-1

Cited by 9 publications

(7 citation statements)

References 168 publications

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“…Human facial aging is increasingly being studied; however, to our knowledge, no studies have investigated the roles of sex hormones in facial aging using GWAS data. Sex hormone levels are thought to fluctuate with age and to be associated with facial aging, and testosterone and bioavailable testosterone levels decline with age, particularly in men ( 26 ). Estradiol levels also decline with age, with a rapid decline in women after menopause ( 27 , 28 ).…”

Section: Discussionmentioning

confidence: 99%

Associations between genetically predicted sex and growth hormones and facial aging in the UK Biobank: a two−sample Mendelian randomization study

Zhao,

Lv,

Zhang

et al. 2023

Front. Endocrinol.

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BackgroundAging is an inescapable process, but it can be slowed down, particularly facial aging. Sex and growth hormones have been shown to play an important role in the process of facial aging. We investigated this association further, using a two-sample Mendelian randomization study.MethodsWe analyzed genome-wide association study (GWAS) data from the UK Biobank database comprising facial aging data from 432,999 samples, using two-sample Mendelian randomization. In addition, single-nucleotide polymorphism (SNP) data on sex hormone-binding globulin (SHBG) and sex steroid hormones were obtained from a GWAS in the UK Biobank [SHBG, N = 189,473; total testosterone (TT), N = 230,454; bioavailable testosterone (BT), N = 188,507; and estradiol (E2), N = 2,607)]. The inverse-variance weighted (IVW) method was the major algorithm used in this study, and random-effects models were used in cases of heterogeneity. To avoid errors caused by a single algorithm, we selected MR-Egger, weighted median, and weighted mode as supplementary algorithms. Horizontal pleiotropy was detected based on the intercept in the MR-Egger regression. The leave-one-out method was used for sensitivity analysis.ResultsSHBG plays a promoting role, whereas sex steroid hormones (TT, BT, and E2) play an inhibitory role in facial aging. Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels had no significant effect on facial aging, which is inconsistent with previous findings in vitro.ConclusionRegulating the levels of SHBG, BT, TT, and E2 may be an important means to delay facial aging.

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Section: Discussionmentioning

confidence: 99%

Associations between genetically predicted sex and growth hormones and facial aging in the UK Biobank: a two−sample Mendelian randomization study

Zhao,

Lv,

Zhang

et al. 2023

Front. Endocrinol.

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“…In addition, a recent study suggested that regular exercise rejuvenated aging skin conditions 35 . A recent review highlighted that lactate acts as a signaling molecule that interacts with mitochondrial biogenesis and turnover and tunes the ability of cells to respond to stressors 36 . Therefore, these physiological adaptations in skin tissue might occur due to lactate accumulation after exercise.…”

Section: Discussionmentioning

confidence: 99%

“…The present results of skin ISF lactate dynamics in this study can provide new hypotheses. Growing evidence suggests that chronic exercise improved skin conditions (2,3), and lactate acts as a signaling molecule that interacts with mitochondrial biogenesis and turnover and tunes the ability of cells to respond to stressors (9). These findings and the present results suggest that the beneficial physiological adaptation of skin tissue to chronic exercise might be due to the accumulated effects of acute exercise-induced long-lasting lactate elevation in the skin ISF.…”

Section: Discussionmentioning

confidence: 99%

Exercise intensity-dependent lactate elevation in skin interstitial fluid and its long-lasting effect

Dobashi,

Funabashi,

Sameshima

et al. 2023

Preprint

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The blood lactate threshold (LT) is a crucial marker of metabolic shifts and stress transitions during exercise, influencing optimal intensity determination and chronic exercise impact evaluation across diverse individuals. Although recent studies have explored methods for estimating blood lactate levels without blood sampling, accurate solutions for LT estimation remain undeveloped. Here, we tested the analytical capability of an ultra-minimally invasive technique for LT measurement that harnesses skin interstitial lactate dynamics using a single microneedle perfusion system. The rats were acclimated to exercise and underwent external jugular vein cannulation. Following comprehensive recovery, a 1 mm single microneedle was implanted into the back skin. This allowed for the simultaneous measurement of lactate concentrations in the blood and skin interstitial fluid during incremental treadmill exercise. Skin lactate progressively increased in tandem with blood lactate during incremental exercise, albeit with lingering post-exercise clearance that did not correlate with blood lactate. Remarkably, LT extrapolated from skin lactate showed significant alignment with blood LT. Our findings reveal the potential of skin interstitial dynamics to accurately assess LT during exercise using a single microneedle, integrating the discoveries of exercise physiology into real-world athletic and/or healthy practices.Graphical abstractRepresentative graphical image of exercise rats with inserted an ultra-minimally invasive single microneedle (A). Representative graph of LT assessed by the blood (B) and skin fluid lactate (C) dynamics. The findings suggest that LT determination using the perfusate collected by the single microneedle perfusion system can be an effective alternative to current methods for measuring blood lactate, which may be a breakthrough in the development of sports science.

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“…In aging, ozone exerts its ability in eliciting pro-survival mechanisms, which usually are induced by low doses of this compound, 23 and which may activate complex regulatory systems involving mitochondria turnover and other regulatory molecules usually associated with stress such as H 2 O 2 and lactate. 24 Most of the finesse in using ozone in the so-called "ozone therapy", 25,26 which is not a therapy but a medical adjunct treatment, lies on the physician's ability in tailoring sound and effective protocols with proper ozone dosages and sound, standardized administration routes. The purpose is to elicit the production of ROS and other mediators, such as 4-HNE, in a way able to induce their "signaling" property, rather than intrinsic toxic activity.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ozone in the adjunct medical treatment. The round personality of a molecule with hormetic properties

Chirumbolo,

Tirelli,

Franzini

et al. 2023

Hum Exp Toxicol

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Ozone, an allotrope of oxygen, is enjoying an increasing interest in the setting and management of the medical adjunct treatment, which is called, maybe too simplistically, “ozone therapy”. Ozone is not a medicine, so the word therapy does not properly fit this gaseous molecule. Like many natural compounds, for example plant flavonoids, even ozone interacts with aryl hydrocarbon receptors (AhRs) and, at low doses, it works according to the paradoxical mechanism of hormesis, involving mitochondria (mitohormesis). Ozone, in the hormetic range, exerts cell protective functions via the Nrf2-mediated activation of the anti-oxidant system, then leading to anti-inflammatory effects, also via the triggering of low doses of 4-HNE. Moreover, its interaction with plasma and lipids forms reactive oxygen species (ROS) and lipoperoxides (LPOs), generally called ozonides, which are enabled to rule the major molecular actions of ozone in the cell. Ozone behaves as a bioregulator, by activating a wide population of reactive intermediates, which usually target mitochondria and their turnover/biogenesis, often leading to a pleiotropic spectrum of actions and behaving as a tuner of the fundamental mechanisms of survival in the cell. In this sense, ozone can be considered a novelty in the medical sciences and in the clinical approach to pharmacology and medical therapy, due to its ability to target complex regulatory systems and not simple receptors.

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Insights on the role of l-lactate as a signaling molecule in skin aging

Cited by 9 publications

References 168 publications

Associations between genetically predicted sex and growth hormones and facial aging in the UK Biobank: a two−sample Mendelian randomization study

Associations between genetically predicted sex and growth hormones and facial aging in the UK Biobank: a two−sample Mendelian randomization study

Exercise intensity-dependent lactate elevation in skin interstitial fluid and its long-lasting effect

Ozone in the adjunct medical treatment. The round personality of a molecule with hormetic properties

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