Insights, strategies, asthma and allergy risk factors, and the allergist/immunologist: Challenges to be met and promises to keep!

Bellanti, Joseph A.; Settipane, Russell A.

doi:10.2500/aap.2016.37.3929

Cited by 3 publications

(7 citation statements)

References 36 publications

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“…Previously cited studies and our findings indicated that the role of environmental CO exposure in MHD patients may be explained by the relationship between inflammation and worsening pruritus 9 45 46 . In addition, in Kim’s study, high odds ratio (8.11) of atopic dermatitis was noted as 1 ppm increased CO level 30 . It is not clear why the difference of odds ratio between Kim’s study and ours.…”

Section: Discussionmentioning

confidence: 87%

“…In a nationwide survery in 6- to 7-year-old children, Kim et al . 30 presented that previous 12-month CO exposure levels were with high odds ratio for the presence of atopic dermatitis. The relationship between environmental CO and dermatits is not clear.…”

Section: Discussionmentioning

confidence: 94%

“…Pruritus in MHD patients might occur possibly because skin barrier destruction induces an increase in neuron-specific enolase-immunoreactive nerve fibers in the epidermis 27 . It is well known that outdoor air pollution affects the health of patients with allergic diseases 28 29 30 31 . To our knowledge, this study is the first to show that environmental air pollutants (NO 2 and CO) are positively associated with UP in MHD patients.…”

Section: Discussionmentioning

confidence: 99%

“…Third, air pollution data were collected and calculated from the previous 12 months and 24 months. In several studies on the association between air pollution and allergic disease, the duration of observation is 12-month 28 29 30 31 . In this study, use of previous 24-month air pollutants levels for analysis additionally is consistent with the effects of previous 12-month environmental air pollutants levels.…”

Section: Discussionmentioning

confidence: 99%

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Environmental NO2 and CO Exposure: Ignored Factors Associated with Uremic Pruritus in Patients Undergoing Hemodialysis

Huang

Lin

Weng

et al. 2016

Sci Rep

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Uremic pruritus (UP), also known as chronic kidney disease–associated pruritus, is a common and disabling symptom in patients undergoing maintenance hemodialysis (MHD). The pathogenesis of UP is multifactorial and poorly understood. Outdoor air pollution has well-known effects on the health of patients with allergic diseases through an inflammatory process. Air pollution–induced inflammation could occur in the skin and aggravate skin symptoms such as pruritus or impair epidermal barrier function. To assess the role of air pollutants, and other clinical variables on uremic pruritus (UP) in HD patients, we recruited 866 patients on maintenance HD. We analyzed the following variables for association with UP: average previous 12-month and 24-month background concentrations for nitrogen dioxide (NO2) and carbon monoxide (CO), and suspended particulate matter of <2.5 μm (PM2.5). In a multivariate logistic regression, hemodialysis duration, serum ferritin levels, low-density lipoprotein levels, and environmental NO2/CO levels were positively associated with UP, and serum albumin levels were negatively associated with UP. This cross-sectional study showed that air pollutants such as NO2 and CO might be associated with UP in patients with MHD.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Environmental NO2 and CO Exposure: Ignored Factors Associated with Uremic Pruritus in Patients Undergoing Hemodialysis

Huang

Lin

Weng

et al. 2016

Sci Rep

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“…While previous investigations have suggested that exposure to higher levels of AAPs are associated with increased prevalence of asthma and allergy [ 36 – 39 ] and that protein expression of IL10 decreased as PAH exposure increased from 24 h to 1 year [ 14 ], previous studies have not specified a critical time of exposure duration. Here, we determined that there was a significant positive association of Foxp3 promoter methylation and pollution for all subjects when there was exposure to certain AAPs (NO 2 , CO, and PM 2.5 ) over the previous 90 days prior to the blood draw .…”

Section: Discussionmentioning

confidence: 99%

Exposure to NO2, CO, and PM2.5 is linked to regional DNA methylation differences in asthma

et al. 2018

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BackgroundDNA methylation of CpG sites on genetic loci has been linked to increased risk of asthma in children exposed to elevated ambient air pollutants (AAPs). Further identification of specific CpG sites and the pollutants that are associated with methylation of these CpG sites in immune cells could impact our understanding of asthma pathophysiology. In this study, we sought to identify some CpG sites in specific genes that could be associated with asthma regulation (Foxp3 and IL10) and to identify the different AAPs for which exposure prior to the blood draw is linked to methylation levels at these sites. We recruited subjects from Fresno, California, an area known for high levels of AAPs. Blood samples and responses to questionnaires were obtained (n = 188), and in a subset of subjects (n = 33), repeat samples were collected 2 years later. Average measures of AAPs were obtained for 1, 15, 30, 90, 180, and 365 days prior to each blood draw to estimate the short-term vs. long-term effects of the AAP exposures.ResultsAsthma was significantly associated with higher differentially methylated regions (DMRs) of the Foxp3 promoter region (p = 0.030) and the IL10 intronic region (p = 0.026). Additionally, at the 90-day time period (90 days prior to the blood draw), Foxp3 methylation was positively associated with NO2, CO, and PM2.5 exposures (p = 0.001, p = 0.001, and p = 0.012, respectively). In the subset of subjects retested 2 years later (n = 33), a positive association between AAP exposure and methylation was sustained. There was also a negative correlation between the average Foxp3 methylation of the promoter region and activated Treg levels (p = 0.039) and a positive correlation between the average IL10 methylation of region 3 of intron 4 and IL10 cytokine expression (p = 0.030).ConclusionsShort-term and long-term exposures to high levels of CO, NO2, and PM2.5 were associated with alterations in differentially methylated regions of Foxp3. IL10 methylation showed a similar trend. For any given individual, these changes tend to be sustained over time. In addition, asthma was associated with higher differentially methylated regions of Foxp3 and IL10.Electronic supplementary materialThe online version of this article (10.1186/s13148-017-0433-4) contains supplementary material, which is available to authorized users.

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The safety of oral immunotherapy for food allergy during maintenance phase: Effect of counselling on adverse reactions

Arasi

Caminiti

Crisafulli

et al. 2019

World Allergy Organization Journal

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Insights, strategies, asthma and allergy risk factors, and the allergist/immunologist: Challenges to be met and promises to keep!

Cited by 3 publications

References 36 publications

Environmental NO2 and CO Exposure: Ignored Factors Associated with Uremic Pruritus in Patients Undergoing Hemodialysis

Environmental NO2 and CO Exposure: Ignored Factors Associated with Uremic Pruritus in Patients Undergoing Hemodialysis

Exposure to NO2, CO, and PM2.5 is linked to regional DNA methylation differences in asthma

The safety of oral immunotherapy for food allergy during maintenance phase: Effect of counselling on adverse reactions

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