Insolubilization of water-soluble dextran

Hirata, Yasushi; Aoki, Mitsuo; Kobatake, Hideki; Yamamoto, Hiroyuki

doi:10.1016/s0142-9612(97)00230-5

Cited by 11 publications

(6 citation statements)

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“…Dextran polymer does not contain charged groups. The mechanism by which it coats the aggregate core is currently under investigation; however, it is likely attributable to numerous hydrogen bonding interactions between the dextran polymer and the aggregate core molecules. , The MCs were aged for 2 h at 4 °C, at which point they were centrifuged at 7,000 rpm for 90 min and resuspended in phosphate-buffered saline (PBS) by sonication. The process was repeated twice to remove excess precursors.…”

Section: Methodsmentioning

confidence: 99%

Biodistribution of Encapsulated Indocyanine Green in Healthy Mice

et al. 2009

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Indocyanine Green (ICG) is a fluorescent probe used in various optically-mediated diagnostic and therapeutic applications. However, utility of ICG remains limited by its unstable optical properties and non-specific localization. We have encapsulated ICG within electrostatically-assembled mesocapsules (MCs) to explore its potential for targeted optical diagnosis and therapy. In this study, we investigate how the surface coating and size of the MCs influences ICG's biodistribution in vivo. ICG was administered intravenously to Swiss Webster mice as a free solution or encapsulated within either 100 nm diameter MCs coated with dextran; 500 nm diameter MCs coated with dextran; or 100 nm diameter MCs coated with 10 nm ferromagnetic iron oxide nanoparticles, themselves coated with polyethylene glycol. ICG was extracted from harvested blood and organs at various times and its amount quantified with fluorescence measurements. MCs containing ICG accumulated in organs of the reticuloendothelial system, namely the liver and spleen, as well as the lungs. The circulation kinetics of ICG remained unaffected by encapsulation; however, the deposition within organs other than the liver suggests a different biodistribution mechanism. Results suggest that the capsules' coating influences their biodistribution to a greater extent than their size. The MC encapsulation system allows for delivery of ICG to organs other than the liver, enabling the potential development of new optical imaging and therapeutic strategies.

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Section: Methodsmentioning

confidence: 99%

Biodistribution of Encapsulated Indocyanine Green in Healthy Mice

et al. 2009

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“…The molecular weight of the dextran fraction can influence the time of the dissolution. A 10% aqueous dextran solution (M w 40 000 g mol -1 ) will develop precipitates during storage, indicating that dextran solutions are not stable [42,50]. The adsorption of dextran molecules on the air-liquid interface is the first step of insolubilisation.…”

Section: Propertiesmentioning

confidence: 99%

Functional Polymers Based on Dextran

Heinze

Liebert

Heublein

et al.

Advances in Polymer Science

253

198

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Dextran, comprising a family of neutral polysaccharides consisting of an α-(1→6) linked d-glucose main chain with varying proportions of linkages and branches, depending on the bacteria used, is an interesting starting material for chemical modification reactions for the design of new functional polymers with promising properties. The review summarises recent results on structure characterisation of dextran including some comments on biosynthesis of this important class of biopolymers. Applications of dextran are discussed as well. Chemical modification reactions of dextran are increasingly studied for the structure and hence property design. The review highlights recent progress in esterification of dextran, both inorganic and organic polysaccharide esters, etherification reactions towards ionic and non-ionic ethers, and the huge variety of different conversions mainly developed for the binding of drugs. It summarises recent developments in the application of dextran derivatives with a focus on the chemical structures behind these materials such as prodrugs, bioactivity of inorganic dextran esters, heparin sulfate mimics, hydrogels, nanoparticles and self assembly structures for surface modification. Keywords Functionalised dextran • Structural analysis • Prodrugs • Nanostructures • Bioactivity Abbreviations AFM Atomic force microscopy AGU Anhydroglucose units AT Antithrombin AZT Azidothymidine BSH Na 2 B 12 H 11 SH BSA Bovine serum albumin CAC Critical association concentration CDI N,N -Carbonyldiimidazole CMC Critical micelle concentration CMD Carboxymethyl dextran CMDB Carboxymethyl dextran benzylamide CMDBSSu Carboxymethyl dextran benzylamidesulfonate sulfate CMDBSu Carboxymethyl dextran benzylamide sulfate CMDEE Carboxymethyl dextran ethyl ester CMDSu Carboxymethyl dextran sulfate COSY Two-dimensional correlated spectroscopy CsA Cyclosporin A 2D Two-dimensional Dach-Pt cis-Dihydroxo(cyclohexane-trans-l-1,2-diamine)platinum II DCC N,N -Dicyclohexylcarbodiimide T. Heinze et al.

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“…9 Estes precipitados podem ainda ser conseqüência de alterações estruturais nas dextranas por associação a íons metálicos. 10,11 É bem estabelecida a precipitação de dextranas em função de sua massa molar e do percentual de etanol presente em diferentes matrizes. 4,12 A relação massa molar versus concentração de etanol é o fundamento de várias metodologias para a análise quantitativa de dextranas, tais como os métodos de Robert's 4,9 e Haze.…”

Section: 2unclassified

Dextranas em açúcares do estado de São Paulo

Aquino¹,

Franco²

2008

Quím. Nova

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Recebido em 15/3/07; aceito em 27/11/07; publicado na web em 8/7/08 DEXTRANS IN SUGARS FROM SÃO PAULO STATE. The characterization of dextran in sugars by size exclusion chromatography (SEC) has been carried out according to the number-average molecular weight (Mn), the weight-average molecular weight (Mw), the Z-average molecular weight (Mz), and the polydispersity (Mw/Mn). The results suggest that all the analyzed thirty sugar samples from São Paulo state were contaminated with two or three different dextran polymers. The collected data clearly point out that the total dextran content together with the mass distribution parameters Mw, Mn, Mz, and Mw/Mn should be considered during the evaluation of the quality of the sugar used for the cachaça sweeting process.

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Insolubilization of water-soluble dextran

Cited by 11 publications

References 0 publications

Biodistribution of Encapsulated Indocyanine Green in Healthy Mice

Biodistribution of Encapsulated Indocyanine Green in Healthy Mice

Functional Polymers Based on Dextran

Dextranas em açúcares do estado de São Paulo

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