Insomnia and risk of mortality from all-cause, cardiovascular disease, and cancer: Systematic review and meta-analysis of prospective cohort studies

Ge, Long; Guyatt, Gordon; Tian, Jinhui; Pan, Bei; Chang, Yaping; Chen, Yajing; Li, Huijuan; Zhang, Junmei; Li, Yahong; Ling, Juan; Yang, Kehu

doi:10.1016/j.smrv.2019.101215

Cited by 127 publications

(87 citation statements)

References 61 publications

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“…Firstly, it has been proposed by Bin that much of these evidence points to connecting sleep duration to physical health, and linking sleep quality to mental health. While several meta-analyses have found significant associations between insomnia and mortality and cardiovascular diseases [ 10 – 12 ], there remains a dearth of research looking at the relationship between sleep disturbance and other physical diseases, or that between sleep duration and psychiatric diseases. Secondly, Bin also highlighted that sleep duration and quality have been conceptualized so distinctly that many have failed to recognise that they are measures of the same underlying phenomenon [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Independent and combined associations of sleep duration and sleep quality with common physical and mental disorders: Results from a multi-ethnic population-based study

et al. 2020

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Sleep duration and sleep quality are often linked to increased risk of mortality and morbidity. However, national representative data on both sleep duration and sleep quality and their relationship with chronic health problems are rarely available from the same source. This current study aimed to examine the independent and combined associations of sleep duration and sleep quality with physical and mental disorders, using data from the Singapore Mental Health Study 2016. 6,126 residents aged �18years participated in this epidemiological, cross-sectional survey. Sleep measures were assessed using the Pittsburg Sleep Quality Index while lifetime or 12-month medical and psychiatric diagnoses were established using the Composite International Diagnostic Interview 3.0. Both short sleep (<6hrs compared to 7-8hrs) and poor sleep were found to be independently associated with chronic pain, obsessive compulsive disorder and any mental disorder while poor sleep was additionally associated with major depressive disorder, bipolar disorder, generalized anxiety disorder and any physical disorder, when adjusted for confounders. Poor sleep combined with short sleep (�6hrs/day vs 7-8hrs/day) was associated with the highest number of comorbidities among other sleep combinations. Sleep duration and sleep quality, when adjusted for each other, remained independently associated with both physical and mental disorders. Affective disorders may be more closely related to poor sleep quality compared to abnormal sleep duration. Our findings suggest sleep quality to be a more important indicator for psychological and overall health compared to sleep duration.

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Section: Introductionmentioning

confidence: 99%

Independent and combined associations of sleep duration and sleep quality with common physical and mental disorders: Results from a multi-ethnic population-based study

et al. 2020

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“…Nýlegar rannsóknir hafa sýnt að afleiðingar af svefntruflunum og svefnsjúkdómum eru ekki einungis tengdar neikvaeðum áhrifum á lífsgaeði, heldur geta leitt til ýmissa algengra langvinnra sjúkdóma eins og háþrýstings, sykursýki 2 og offitu, sem allt eru sjúkdómar sem eiga það sameiginlegt að auka líkur á þróun hjarta-og aeðasjúkdóma. [3][4][5][6][7][8][9][10][11] Markmiðið með þessu yfirliti er að taka saman niðurstöður nýlegra rannsókna sem skoða tengsl svefnraskana (svefngaeða, svefnlengdar og svefnsjúkdóma) og langvinnra sjúkdóma með áherslu á hjarta-og aeðasjúkdóma og vekja athygli á svefni sem þaetti í forvörnum og meðferð þessara sjúkdóma. 3,12 Leitað var í PubMed-gagnagrunni að ritrýndum greinum sem birtar hafa verið á síðustu 5 árum undir leitarorðunum svefngaeði, svefnlengd, hormóns, styrkur þess haekkar þegar líður að svefntíma og naer hámarki við innleiðingu svefns en laekkar svo aftur í djúpsvefni og eftir því sem líður á svefntímann.…”

Section: Inngangurunclassified

“…22 Hver svo sem ástaeðan er geta afleiðingar af óreglulegum og/eða stuttum svefni og lélegum svefngaeðum komið fram í margvíslegum birtingarmyndum með neikvaeðum áhrifum á heilsu, þar með talið á hjarta-og aeðakerfið. 2,3,6,9,[23][24][25][26][27][28][29][30][31][32]…”

Section: Helstu Orsakir Svefnkvartanaunclassified

“…13 Þaer ráðleggingar eru byggðar á rannsóknum sem sýnt hafa að baeði of stuttur og of langur svefn geti haft neikvaeð áhrif á heilsu og að þeir sem reglulega sofa skemur eða lengur en núverandi ráðleggingar maela með séu líklegri til að þróa með sér langvinna sjúkdóma. 2,3,[5][6][7][8][9][10][11] Hversu langur svefntíminn er segir samt ekki alla söguna því jafnframt þarf að huga að reglu og gaeðum svefnsins. [14][15][16] Svefn er lífeðlisfraeðilega flókið ferli sem meðal annars stjórnast af áhrifum daegursveiflu ljóss á undirstúku heila og uppsöfnun á adenosíni í miðtaugakerfi sem veldur aukinni syfju eftir að einstaklingur hefur verið vakandi í 12-16 klukkustundir.…”

Section: Svefnunclassified

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The role of sleep and sleep disorder management in reducing cardiovascular- and cardiometabolic risk and improving treatment outcomes

Magnusdottir¹,

Sveinsdóttir²

2020

LBL

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Despite extensive knowledge on the importance of quality sleep for health and wellbeing, sleep quality and sleep disorders are commonly overlooked in both prevention and treatment of chronic illnesses. The aim of this review is to draw attention to recently published literature focusing on how disrupted sleep contributes to the onset and progression of chronic diseases, with focus on cardiovascular- and cardiometabolic diseases. Diagnosis and management of sleep disorders are an important part of prevention and chronic disease management to optimize outcomes and improve patients´ health and quality of life. Objective sleep disorder diagnosis is relevant to ensure appropriate therapy intervention, and for sleep disorders to be managed as other chronic diseases based on regular objective assessments of treatment efficacy. In light of the knowledge of how short sleep and/or low sleep quality negatively affects the cardiovascular system, including objective sleep evaluation in the standard of care for risk assessment and management of cardiovascular diseases may improve cardiovascular risk prediction and improve outcomes.

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“…A recent global prospective cohort study reported a J-shaped association between the measured duration of total daily sleep and mortality and major cardiovascular events [10]. A number of meta-analyses also demonstrated that sleep problems such as excessive (short or long) sleep durations or poor sleep quality may increase the overall risk of CVD and all-cause mortality [11][12][13][14][15] and the results suggest that sleep management may be essential in preventing CVD.…”

Section: Introductionmentioning

confidence: 99%

Association of sleep disturbance with risk of cardiovascular disease and all-cause mortality in patients with new-onset type 2 diabetes: data from the Korean NHIS-HEALS

Choi

2020

Cardiovasc Diabetol

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Background: Sleep disturbance has been significantly associated with the incidence of cardiovascular disease (CVD) in the general population. However, despite the common prevalence of sleep disturbance in patients with type 2 diabetes, its relationship with the risk of CVD remains unclear. Here, we have examined the association of sleep disturbance with the incidence of all CVD and all-cause mortality in patients with newly-diagnosed type 2 diabetes. Methods: We used the Korean National Health Insurance Service-Health Screening Cohort data and included 36,058 patients with new-onset type 2 diabetes aged ≥ 40 years between 2004 and 2007, along with follow-up examinations to 2013. We used the ICD-10 code to measure sleep disturbance as a primary diagnosis and the multivariable Cox proportional hazards regression models to estimate the adjusted hazard ratio (AHR) and 95% confidence interval (CI) of all CVD, coronary heart disease (CHD), stroke, and all-cause mortality. Results: We identified 6897 cases of all CVD (CHD, n = 4138; stroke, n = 2759) and 2890 events of all-cause mortality during a mean follow-up period of 7.0 years. Sleep disturbance was associated with an increased risk of All CVD (AHR, 1.24; 95% CI, 1.06-1.46), CHD events (AHR, 1.24; 95% CI, 1.00-1.53), and all-cause mortality (AHR, 1.47; 95% CI, 1.15-1.87) in patients with new-onset type 2 diabetes. Furthermore, women (AHR, 1.33; 95% CI, 1.06-1.67) and middle-aged adults (AHR, 1.29; 95% CI, 1.02-1.64) with sleep disturbance had a significantly increased risk of CVD than those without; contrarily, men (AHR, 1.45; 95% CI, 1.09-1.95) and older adults (AHR, 1.51; 95% CI, 1.15-1.99) with sleep disturbance were associated with a significantly increased risk of all-cause mortality than those without. Conclusions: Our findings suggest that sleep disturbance is significantly associated with an increased risk of CVD and all-cause mortality in patients with new-onset type 2 diabetes.

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Insomnia and risk of mortality from all-cause, cardiovascular disease, and cancer: Systematic review and meta-analysis of prospective cohort studies

Cited by 127 publications

References 61 publications

Independent and combined associations of sleep duration and sleep quality with common physical and mental disorders: Results from a multi-ethnic population-based study

Independent and combined associations of sleep duration and sleep quality with common physical and mental disorders: Results from a multi-ethnic population-based study

The role of sleep and sleep disorder management in reducing cardiovascular- and cardiometabolic risk and improving treatment outcomes

Association of sleep disturbance with risk of cardiovascular disease and all-cause mortality in patients with new-onset type 2 diabetes: data from the Korean NHIS-HEALS

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