Mental health is a dynamic balance. Generalized mental health is a kind of status that is efficient and satisfactory to the environment with the rapid development of science and technology and the continuous improvement of social material living standard, mental health is getting more and more attentions extensively. The characteristics of the nursing work causes high intensity stress state, not only induce to fatigue but also affects mental health. Objective: To understand the clinical nurses'mental health condition, and perform different forms of mental health education practice accordingly. Method: The symptom self-assessment scale (SCL-90) was used to investigate among 704 clinical nurses. Results: Except interpersonal sensitivity factor, the somatization, force, depression, anxiety, fear, hostility, paranoid, psychotic factor, and total average score of SCL-90 of nurse were higher than that of domestic norm and the female norm (P<0. 01). The positive statistical indicators of force, interpersonal sensitivity and depression factor were relatively high. Conclusion: The high strength work pressure have serious impact on the clinical nurses' mental health, managers must attach great importance to it and actively take countermeasures. Nurses also need to strengthen self-consciousness of mental health and learn self-management methods. The overall mental health level in nurse group is very important in hospital. To receive this target, hospitals should establish an external operating mechanism to allow nurses to accept continuous psychology health education and counseling.