Insomnia as a predictor of depression: A meta-analytic evaluation of longitudinal epidemiological studies

Baglioni, Chiara; Battagliese, Gemma; Feige, Bernd; Spiegelhalder, Kai; Nissen, Christoph; Voderholzer, Ulrich; Lombardo, Caterina; Riemann, Dieter

doi:10.1016/j.jad.2011.01.011

Cited by 2,113 publications

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“…Negative emotions such as anxiety and depression are linked to both sleep and paranoia (Baglioni et al, 2011;Freeman et al, 2012) and have been identified as potential mediators. Indeed, research has shown that negative emotions account largely for the relationship between sleep and paranoia (Freeman et al, 2009(Freeman et al, , 2010Mulligan et al, 2016;Reeve et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Sleep quality and paranoia: The role of alexithymia, negative emotions and perceptual anomalies

Rehman

Gumley

Biello

2018

Psychiatry Research

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A B S T R A C TRecent evidence suggests that sleep problems are associated with psychotic like experiences including paranoia. However, the mechanisms underpinning this association are not well understood and thus studies modelling hypothesised mediating factors are required. Alexithymia, the inability to recognise and describe emotions within the self may be an important candidate. In two separate studies we sought to investigate factors mediating the relationship between sleep quality and paranoia using a cross-sectional design. Healthy volunteers without a mental health diagnosis were recruited (study 1, N = 401, study 2, N = 402). Participants completed a series of measures assessing paranoia, negative emotions, alexithymia and perceptual anomalies in an online survey. In study 1, regression and mediation analyses showed that the relationship between sleep quality and paranoia was partially mediated by alexithymia, perceptual anomalies and negative affect. In contrast, study 2 found that the relationship between sleep quality and paranoia was fully mediated by negative affect, alexithymia and perceptual anomalies. The link between sleep quality and paranoia is unclear and reasons for discrepant results are discussed. Novel findings in this study include the link between alexithymia and paranoia.

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Section: Introductionmentioning

confidence: 99%

Sleep quality and paranoia: The role of alexithymia, negative emotions and perceptual anomalies

Rehman

Gumley

Biello

2018

Psychiatry Research

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“…Almost a third of adults suffer from insomnia which it increases up to approximately 69 percent with increased age and chronic diseases (Zhang et al, 2007). Also according to the research, insomnia weakens physical strength and causes stress and anxiety (Björnsdóttir et al, 2013); it also affects the central nervous system (Baglioni et al, 2011). Gooneratne and colleagues (2007) in a study to examine sleep and quality of life of patients who had lung cancer concluded that 56% of patients had poor sleep quality.…”

Section: Introductionmentioning

confidence: 99%

Sleep Quality and Associated Risk Factors in Leukemia Patients Undergoing Chemotherapy in Iran

Bagheri-Nesami

Goudarzian²,

Babaei³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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This study aimed to determine sleep disorders and associated risk factors in leukemia patients undergoing chemotherapy in Imam Khomeini Hospital of Sari, Iran. This cross-sectional study was conducted in 2015 with 100 patients selected. Inclusion criteria included complete mental and psychological health and being over 18 years old, and exclusion criteria included suffering other cancers, other chronic diseases, concurrent radiotherapy, and chemotherapy. The Pittsburgh Sleep Quality standard questionnaire was used to collect data. The questionnaire consisted of mental sleep quality, sleep latency, sleep duration, sleep quality, sleep disturbances, use of sleeping drugs, and impaired daily functioning. Data were analyzed by software SPSS 18 and by using descriptive and inferential tests (Pearson, Spearman, T-test and chi-square). Totals of 47 men (47%) and 53 women (53%) with a mean age of 44.1±1.7, participated in the study. The mean overall score of sleep quality was 9.3±3.9, which represents the average sleep quality in most participants. T-test shows that males have better sleep quality than females (t=2.1; 95%CI:0.004-0.25; P<0.01). Also the sleep quality increased with age (r=0.22, P=0.03). Results show that the amount of sleep quality was only moderate in most patients, so it is necessary to take coping strategies to improve their quality of sleep.

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“…Targeted prevention of affective disorders in people at risk, as well as identification of mechanisms of conversion, could be the most viable approach to mitigate their increasing global burden (1). For the prevention of new-onset or recurrent affective disorder, insomnia may be the major risk factor that can be targeted best (2,3). About 13% of people with insomnia develop major depression disorder (MDD) within a year (2).…”

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“…For the prevention of new-onset or recurrent affective disorder, insomnia may be the major risk factor that can be targeted best (2,3). About 13% of people with insomnia develop major depression disorder (MDD) within a year (2). Moreover, remission rates after cognitive behavioral therapy are 21% lower for depressed patients with abnormal sleep compared with patients with relatively intact sleep (4).…”

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Slow dissolving of emotional distress contributes to hyperarousal

Wassing

Benjamins

Dekker

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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The mechanisms underlying hyperarousal, the key symptom of insomnia, have remained elusive, hampering cause-targeted treatment. Recently, restless rapid-eye-movement (REM) sleep emerged as a robust signature of sleep in insomnia. Given the role of REM sleep in emotion regulation, we hypothesized that restless REM sleep could interfere with the overnight resolution of emotional distress, thus contributing to accumulation of arousal. Participants (n = 1,199) completed questionnaires on insomnia severity, hyperarousal, self-conscious emotional distress, and thought-like nocturnal mentation that was validated to be a specific proxy for restless REM sleep (selective fragmentation: R = 0.57, P < 0.001; eye movement density: R = 0.46, P < 0.01) in 32 polysomnographically assessed participants. The experience of distress lasting overnight increased with insomnia severity (β = 0.29, P < 10 −23 ), whereas shortlasting distress did not (β = −0.02, P = 0.41). Insomnia severity was associated with hyperarousal (β = 0.47, P < 10 −63 ) and with the thought-like nocturnal mentation that is specifically associated with restless REM sleep (β = 0.31, P < 10 −26 ). Structural equation modeling showed that 62.4% of the association between these key characteristics of insomnia was mediated specifically by reduced overnight resolution of emotional distress. The model outperformed all alternative mediation pathways. The findings suggest that restless REM sleep reflects a process that interferes with the overnight resolution of distress. Its accumulation may promote the development of chronic hyperarousal, giving clinical relevance to the role of REM sleep in emotion regulation in insomnia, depression, and posttraumatic stress disorder.B oth insomnia and affective disorders are among the most prevalent and burdening health concerns facing our society. Targeted prevention of affective disorders in people at risk, as well as identification of mechanisms of conversion, could be the most viable approach to mitigate their increasing global burden (1). For the prevention of new-onset or recurrent affective disorder, insomnia may be the major risk factor that can be targeted best (2, 3). About 13% of people with insomnia develop major depression disorder (MDD) within a year (2). Moreover, remission rates after cognitive behavioral therapy are 21% lower for depressed patients with abnormal sleep compared with patients with relatively intact sleep (4). It therefore appears highly relevant to understand the mechanisms involved in the role of insomnia in disturbed emotion regulation (2). The present study addresses the roles of restless rapid-eye-movement (REM) sleep (5) and chronic physiological arousal (6), which are characteristic of both insomnia and MDD.Although sleep contributes to the more robust consolidation of emotional memories, relative to neutral memories (7, 8), their later recall is not associated with anywhere near the same magnitude of subjective emotional distress, autonomic arousal, and amygdala activation (7, 9-11). REM sleep p...

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Insomnia as a predictor of depression: A meta-analytic evaluation of longitudinal epidemiological studies

Cited by 2,113 publications

References 64 publications

Sleep quality and paranoia: The role of alexithymia, negative emotions and perceptual anomalies

Sleep quality and paranoia: The role of alexithymia, negative emotions and perceptual anomalies

Sleep Quality and Associated Risk Factors in Leukemia Patients Undergoing Chemotherapy in Iran

Slow dissolving of emotional distress contributes to hyperarousal

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