Insomnia: Risk Factor for Neurodegenerative Diseases

Shamim, Sohaib A; Warriach, Zain I; Tariq, Marium; Rana, Kiran F; Malik, Bilal Haider

doi:10.7759/cureus.6004

Cited by 34 publications

(39 citation statements)

References 26 publications

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“…The sleep patterns of these patients are characterized by increased sleep fragmentation, decreased sleep efficiency, and a reduced slow-wave sleep (SWS) ratio ( 4 ). Insomnia is frequently associated with cognitive decline and is thought to be partly responsible for the pathological progression of several neurodegenerative diseases ( 6 ). According to the results of our prophase research, the disruption of sleep continuity caused by insomnia can aggravate the impairment of executive function and memory in CSVD patients ( 4 ), suggesting that treating insomnia might be a potential target for improving the cognitive function of CSVD patients.…”

Section: Introductionmentioning

confidence: 99%

Effects of Trazodone on Sleep Quality and Cognitive Function in Arteriosclerotic Cerebral Small Vessel Disease Comorbid With Chronic Insomnia

et al. 2020

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Background Chronic insomnia is common in patients with arteriosclerotic cerebral small vessel disease (CSVD) and aggravates the cognitive impairment caused by CSVD. Low-dose trazodone is effective in treating insomnia, but it is unclear whether it can also improve cognitive function in CSVD patients. This study was performed to explore the effects of trazodone on sleep quality and cognitive function in CSVD comorbid with chronic insomnia. Methods This was a randomized, double-blind, placebo-controlled pilot study. Forty patients suffering from arteriosclerotic CSVD and insomnia were recruited from an outpatient clinic. Participants were randomized individually to receive either trazodone (study group) or a placebo (control group) for 4 weeks. The primary outcome was the cognitive score on the Montreal Cognitive Assessment scale (MoCA). Secondary outcomes included sleep parameters measured with polysomnography (PSG) and the Pittsburgh Sleep Quality Index. Results Trazodone caused significantly better improvements in concentration and recall abilities, measured with MoCA, as well as in PSG parameters such as sleep efficiency, N3 sleep ratio, and sleep continuity than the placebo, with no significant differences in the occurrence of side effects. The improvement of sleep quality was correlated with increased concentration and recall abilities. Conclusions A low dose of trazodone seems acceptable and effective in reducing insomnia severity and improving concentration and recall abilities in this pilot study. The improvement of cognition could be achieved by alleviation of insomnia severity. Considering the high incidence of insomnia in CSVD patients, the results of this preliminary study support the use of low-dose trazodone to deal with insomnia and cognitive impairment in CSVD.

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Section: Introductionmentioning

confidence: 99%

Effects of Trazodone on Sleep Quality and Cognitive Function in Arteriosclerotic Cerebral Small Vessel Disease Comorbid With Chronic Insomnia

et al. 2020

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“…Sleep disorders have been announced as a public health epidemic by the Centers for Disease Control and Prevention (CDC), and according to data, chronic sleep loss and disturbances in sleeping behavior have been related to serious metabolic, endocrine, and systemic diseases including obesity, diabetes mellitus, coronary heart disease, cancer, and stroke [1][2][3]. Also, the risk of developing Alzheimer's disease is 1.5 times greater in individuals with low sleep quality [4]. Short-term sleep deprivation leads to cognitive impairment, diminished concentration, and impaired intellectual capacity, which might lead to accidents, depressive symptoms, as well as psychotic behavior in individuals with a neuropsychological tendency [5].…”

Section: Introductionmentioning

confidence: 99%

The effect of COVID-19 pandemic on sleeping status

Demir¹

2020

Journal of Surgery and Medicine

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All procedures in this study involving human participants were performed in accordance with the 1964 Helsinki Declaration and its later amendments. Etik Kurul Onayı: Etik kurul onayı İstanbul Yeni Yüzyıl Üniversitesi, Fen Bilimleri, Sosyal ve Girişimsel Olmayan Sağlık Bilimleri Araştırmaları Etik Kurulu'ndan (Sayı: 2020/04-05) alınmıştır. İnsan katılımcıların katıldığı çalışmalardaki tüm prosedürler, 1964 Helsinki Deklarasyonu ve daha sonra yapılan değişiklikler uyarınca gerçekleştirilmiştir.

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“…Growing evidence suggests that it is also quite prevalent in the middle-aged population (3), postmenopausal women (4), the elderly (5), cancer patients (6), and those suffering from mental and chronic diseases (3). Even worse, as is reported, it serves as a risk factor for depression and hypertension (7), neurodegenerative disorders (8), and cardiovascular diseases (9), and it even increases mortality (10), which heavily compromises people's health and imposes a constant and growing economic burden on patients and society. It is therefore urgent and crucial to explore a safe, effective, economic, and feasible method to address sleep problems.…”

Section: Introductionmentioning

confidence: 99%

Effect of Pilates on Sleep Quality: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Chen

Shen

et al. 2020

Front. Neurol.

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Objective: Pilates exercise is increasingly used to improve sleep quality, but relevant evidence remains unclear. We aimed to estimate the effect of Pilates on sleep quality.Methods: Five databases were searched for articles published until 10 December 2019. Two investigators screened the articles and extracted data from each included study. A meta-analysis was performed to evaluate the effect of Pilates on sleep quality, assessed using the Pittsburgh Sleep Quality Index (PSQI).Results: Six randomized controlled trials (RCTs) comprising 477 participants were included according to the inclusion and exclusion criteria in the study. All included studies reported the positive effects Pilates had on sleep quality. The Pilates group (PG) significantly lowered the PSQI total score (MD = −3.60, 95%CI: [−5.41, −1.78), P = 0.0001, I 2 = 97%) compared to the non-exercising control group (CG), whereas no significant improvement in use of sleep medication was observed (MD = −0.33, 95%CI: [−0.73, −0.06), P = 0.10, I 2 = 68%). However, in a subgroup analysis, we found that there was no significant reduction in the PSQI total score for healthy participants over 40 years old (MD = −3.73, 95%CI: [−7.89, 0.42], P = 0.08, I 2 = 98%) and for postmenopausal women (MD = −5.55, 95%CI: [−13.98, −2.89], P = 0.20, I 2 = 98%). Conclusions:Overall, Pilates improved sleep quality but had no significant effect on the use of sleep medication. However, Pilates showed no significant impact on sleep quality for healthy individuals over 40 years old and for postmenopausal women. Well-designed and large-scale RCTs are needed in the future.

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Insomnia: Risk Factor for Neurodegenerative Diseases

Cited by 34 publications

References 26 publications

Effects of Trazodone on Sleep Quality and Cognitive Function in Arteriosclerotic Cerebral Small Vessel Disease Comorbid With Chronic Insomnia

Effects of Trazodone on Sleep Quality and Cognitive Function in Arteriosclerotic Cerebral Small Vessel Disease Comorbid With Chronic Insomnia

The effect of COVID-19 pandemic on sleeping status

Effect of Pilates on Sleep Quality: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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