Insomnia, sleep quality, pain, and somatic symptoms: Sex differences and shared genetic components

Zhang, Jihui; Lam, Siu Ping; Li, S. X.; Tang, Nelson L.S.; Yu, Manda; Li, A. M.; Wing, Yun Kwok

doi:10.1016/j.pain.2011.12.003

Cited by 92 publications

(75 citation statements)

References 44 publications

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“…That study reported robust associations of the ISI with the severity of pain and non-pain somatic complaints over the prior week, after controlling for the Hospital Anxiety and Depression Scale scores (48) which overlap in content with the distress, anxiety and depression subscales of the 4-DSQ. In conclusion, our result with respect to somatic complaints within 1 week can be regarded as corroborating the finding of Zhang et al (15), whereas the result on pain intensity generalizes their finding to a longer reference period (up to 6 months).…”

Section: Discussionsupporting

confidence: 93%

“…Furthermore, different sets of psychological symptoms (or none at all) were controlled for in different studies, making comparisons somewhat difficult. The most similar study to the current one, but of a smaller scale, was conducted by Zhang et al (15). That study reported robust associations of the ISI with the severity of pain and non-pain somatic complaints over the prior week, after controlling for the Hospital Anxiety and Depression Scale scores (48) which overlap in content with the distress, anxiety and depression subscales of the 4-DSQ.…”

Section: Discussionmentioning

confidence: 74%

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Insomnia Really Hurts: Effect of a Bad Night's Sleep on Pain Increases With Insomnia Severity

2018

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Insomnia and chronic pain are highly prevalent conditions and are often comorbid. Somatic complaints other than pain are also often observed in insomnia. Poor sleep and pain are known to mutually reinforce each other. However, it is unknown whether the habitual severity of insomnia modulates the acute effect of a particularly bad night's sleep on the next day's pain severity, and whether it modulates the acute effect of pain on the following night's sleep quality. Using data from 3,508 volunteers (2,684 female, mean age 50.09 y), we addressed these questions in addition to the associations between the habitual severity of insomnia, somatic complaints, and pain. Results indicated that people suffering from more severe habitual insomnia showed stronger mutual acute within-day reactivity of pain and poor sleep quality. The same increased reactivity was found in people with more severe habitual pain. Interestingly, the acute within-day mutual reactivity of pain and sleep quality showed consistent asymmetry. Pain worsened more after a particularly bad night's sleep than it improved after a particularly good night's sleep. Likewise, sleep worsened more after a day with more-than-usual pain than it improved after a day with less-than-usual pain. Future interventions may profit from addressing this asymmetric mutual reactivity especially in people with severe comorbid insomnia and chronic pain.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 74%

Insomnia Really Hurts: Effect of a Bad Night's Sleep on Pain Increases With Insomnia Severity

2018

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“…An added complication is that commonly comorbid depression or anxiety symptoms may better account for poor sleep quality in individual with chronic pain than pain symptoms (27). However, populations with insomnia (28) or migraine (29) maintain the pain-poor sleep quality relationship after controlling for depression so the influence of depression and anxiety on the association between poor sleep quality and pain may depend on the clinical population being studied (8). …”

Section: Discussionmentioning

confidence: 99%

Familial Contributions to Self-Reported Sleep and Pain in Female Twins

et al. 2015

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Objective The relationship between sleep quality and pain has been studied in populations with chronic pain and non-clinical populations in experimental paradigms. Little is known about the familial contributions to this relationship. This study examines self-reported sleep quality and pain in a non-clinical sample and to explore familial (i.e., shared genetic and common family environment) confounding in those relationships. Design Cross-sectional. Subjects 99 community-based female twin pairs (N = 198) with a mean age of 29 years; 72% monozygotic. Methods The short form McGill Pain Questionnaire (McGill), a visual analog scale (VAS), a body map, and the Pittsburgh Sleep Quality Index (PSQI) measured self-reported pain and sleep quality. Mixed model regression adjusted for age was used to examine relationships between the pain indices and PSQI in overall and within-pair models. Results Higher PSQI total scores were significantly associated with higher scores across the sensory (B = 0.37, p < 0.001), affective (B = 0.16, p < 0.001), total scores (B = 0.54, p < 0.001) on the McGill and the VAS (B = 2.41, p < 0.001), and number of sites with any pain on the body map (B = 0.42, p = 0.001). All of these associations were diminished and rendered non-significant in within-pair analyses that accounted for genetic and familial factors (all p’s α 0.01; Bonferroni α = 0.01). Conclusions These findings support an association between poor sleep quality and pain and suggest that this relationship may be confounded by shared genetic and environmental factors, which could elucidate biological mechanisms that underlie the development and maintenance of pain and sleep problems.

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“…14 Furthermore, poor sleep health, such as insomnia, has been associated with greater sensitivity to pain. 15 That said, many inconsistencies are evident in the risk of development, severity, frequency, and duration of headache between females and males and whether there is a gender difference in effects of chronic headache. 13,[16][17][18] Furthermore, the interaction of chronic headache, sleep insufficiency, and gender, to our knowledge, has not been well studied especially in the adolescent population.…”

Section: Introductionmentioning

confidence: 99%