Insomnia symptom severity and cognitive performance: Moderating role of <i>APOE</i> genotype

Baril, Andrée‐Ann; Beiser, Alexa S.; Sanchez, Erlan; Mysliwiec, Vincent; Redline, Susan; Gottlieb, Daniel J.; O’Connor, George T.; Gonzales, Mitzi M.; Himali, Dibya; Seshadri, Sudha; Himali, Jayandra J.; Pase, Matthew P.

doi:10.1002/alz.12405

Cited by 18 publications

(15 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, APOE ε4 allele carriers with sleep disturbances might affect ongoing neurodegenerative pathology and contribute to the deterioration rate of dementia, which happened in cognitively impaired seniors (Chen et al, 2017). Furthermore, from the perspective of population research, Baril et al (2022) confirmed the moderating role of the APOE genotype between insomnia and neurodegeneration in participants aged 44-84 years old. In our review, there is an association in cognitively impaired individuals.…”

Section: Discussionmentioning

confidence: 78%

The Relationship Between Sleep Disturbance and Apolipoprotein E ε4 in Adults With Mild Cognitive Impairment and Alzheimer’s Disease Dementia: An Integrative Review

Wei

Wang

Shi

et al. 2022

Biological Research For Nursing

View full text Add to dashboard Cite

Background Apolipoprotein E ε4 (APOE ε4) was shown to be a risk factor for mild cognitive impairment (MCI) and Alzheimer’s disease (AD) dementia. When coupled with sleep disturbance, APOE ε4 posed additional risks to cognitive impairment. But the literature on the association between sleep disturbance and the APOE ε4 status of persons who are cognitively impaired has not yet been systematically examined. Objectives To explore and synthesize the relationship between sleep disturbance and APOE ε4 status of adults with MCI and AD. Methods An integrative review was guided by Whittemore and Knafl’s methodology. Systematic searches identified studies with multiple sources published before May 20, 2021. A matrix and narrative synthesis was employed to organize and synthesize the findings. Joanna Briggs Institute (JBI) Critical Appraisal tools (2020) were used to evaluate the quality of the selected studies. Results A total of 7 studies were included. APOE ε4 was associated with poor sleep quality in terms of the deterioration of nighttime total sleep time, 24-hour total sleep time, rapid eye movement, sleep efficiency, sleep latency, and wake after sleep onset in a population with MCI or AD. The interacted and adjusted relationship between sleep disturbance and APOE ε4 on the progression of cognitive decline was inconsistent. Conclusions There is evidence to support an association between sleep disturbance and APOE ε4 in individuals with cognitive impairment, but a further examination of the relationship between sleep parameters and APOE ε4 is warranted, especially as the causal or dose–response relationship remains unclear.

show abstract

Section: Discussionmentioning

confidence: 78%

The Relationship Between Sleep Disturbance and Apolipoprotein E ε4 in Adults With Mild Cognitive Impairment and Alzheimer’s Disease Dementia: An Integrative Review

Wei

Wang

Shi

et al. 2022

Biological Research For Nursing

View full text Add to dashboard Cite

show abstract

“…In terms of disorder severity, there is consistent evidence suggesting that the severity of CI is negatively related to CF in general, particularly in memory tests. 21 Meanwhile, the severity of MDD has shown negative correlations in some instances and no association with CF in others, as reported in recent reviews. 22 In summary, the available evidence indicates that sleep is associated with CF in both MDD and CI.…”

Section: Introductionmentioning

confidence: 88%

“…[13][14][15][16][17][18][19] However, it is important to consider that pharmacological treatment of MDD and CI may alter sleep patterns, 20 and the severity of these disorders could be related to CF. 21,22 For instance, it has been reported that in patients with a current episode of MDD 23 and in those with subclinical depression, 24 a decrease in subjective sleep quality is associated with worse performance on tasks of psychomotor speed, cognitive flexibility, and semantic fluency. Furthermore, both subjective sleep quality and depression severity independently predict self-reported cognitive impairment, but only sleep quality is associated with objectively measured cognitive impairment.…”

Section: Introductionmentioning

confidence: 99%

Polysomnographic parameters associated with cognitive function in patients with major depression and insomnia

Olivera-López,

Jiménez-Genchi,

Ortega-Robles

et al. 2024

CNS Spectr.

View full text Add to dashboard Cite

Objective To examine whether objective sleep parameters are associated with cognitive function (CF) in patients with major depressive disorder (MDD) with chronic insomnia (CI) and whether the severity of these disorders is related to CF. Method Thirty patients with MDD with CI attending a tertiary care institution underwent two consecutive nights of polysomnographic (PSG) recording and a battery of neuropsychological tests, which included episodic memory, sustained attention, working memory, and executive function. The severity of MDD and CI was assessed by clinical scales. We examined the relationship between PSG parameters and CF, as well as whether the severity of the disorders is related to CF. Results Linear regression analysis revealed that total sleep time (TST) was positively associated with higher learning and recall of episodic memory, as well as better attention. Slow-wave sleep (SWS) showed a positive association with better working memory. Furthermore, wake after sleep onset (WASO) was negatively associated with episodic memory and lower attention. No significant relationships were found between the severity of MDD or CI with CF. Conclusion Both sleep duration and depth are positively associated with several aspects of CF in patients with MDD with CI. Conversely, a lack of sleep maintenance is negatively related to CF in these patients. These findings could help identify modifiable therapeutic targets to reduce CF impairment.

show abstract

“…AD is well acknowledged that genetic disturbance is an important pathological driving force of AD ( Lane et al, 2018 ). Poor sleep seems to exacerbate neurodegeneration ( Grimmer et al, 2020 ; Baril et al, 2022 ; Blackman et al, 2022 ). Genome-wide studies identified more than 20 high-risk genes associated with AD from thousands of patients.…”

Section: Introduction To Sleep Disturbance and Alzheimer’s Diseasementioning

confidence: 99%

Possible Neuropathology of Sleep Disturbance Linking to Alzheimer’s Disease: Astrocytic and Microglial Roles

Xiao

Liu

Wang

et al. 2022

Front. Cell. Neurosci.

View full text Add to dashboard Cite

Sleep disturbances not only deteriorate Alzheimer’s disease (AD) progress by affecting cognitive states but also accelerate the neuropathological changes of AD. Astrocytes and microglia are the principal players in the regulation of both sleep and AD. We proposed that possible astrocyte-mediated and microglia-mediated neuropathological changes of sleep disturbances linked to AD, such as astrocytic adenosinergic A1, A2, and A3 regulation; astrocytic dopamine and serotonin; astrocyte-mediated proinflammatory status (TNFα); sleep disturbance-attenuated microglial CX3CR1 and P2Y12; microglial Iba-1 and astrocytic glial fibrillary acidic protein (GFAP); and microglia-mediated proinflammatory status (IL-1b, IL-6, IL-10, and TNFα). Furthermore, astrocytic and microglial amyloid beta (Aβ) and tau in AD were reviewed, such as astrocytic Aβ interaction in AD; astrocyte-mediated proinflammation in AD; astrocytic interaction with Aβ in the central nervous system (CNS); astrocytic apolipoprotein E (ApoE)-induced Aβ clearance in AD, as well as microglial Aβ clearance and aggregation in AD; proinflammation-induced microglial Aβ aggregation in AD; microglial-accumulated tau in AD; and microglial ApoE and TREM2 in AD. We reviewed astrocytic and microglial roles in AD and sleep, such as astrocyte/microglial-mediated proinflammation in AD and sleep; astrocytic ApoE in sleep and AD; and accumulated Aβ-triggered synaptic abnormalities in sleep disturbance. This review will provide a possible astrocytic and microglial mechanism of sleep disturbance linked to AD.

show abstract

Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype

Cited by 18 publications

References 57 publications

The Relationship Between Sleep Disturbance and Apolipoprotein E ε4 in Adults With Mild Cognitive Impairment and Alzheimer’s Disease Dementia: An Integrative Review

The Relationship Between Sleep Disturbance and Apolipoprotein E ε4 in Adults With Mild Cognitive Impairment and Alzheimer’s Disease Dementia: An Integrative Review

Polysomnographic parameters associated with cognitive function in patients with major depression and insomnia

Possible Neuropathology of Sleep Disturbance Linking to Alzheimer’s Disease: Astrocytic and Microglial Roles

Contact Info

Product

Resources

About