Insomnia symptoms in relation to menopause among middle-aged Chinese women: Findings from a longitudinal cohort study

Luo, Meiling; Li, Jiayi; Tang, Ruiyi; Li, Howard J.; Liu, Bing; Peng, Yi; Wang, Yuchen; Liu, Gaifen; Lin, Shunquan; Chen, Rong

doi:10.1016/j.maturitas.2020.06.010

Cited by 26 publications

(18 citation statements)

References 27 publications

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“…In this study, we also found that treatment with estradiol valerate significantly improved the levels of LH, FSH, and E2 hormones in the study group compared with the control group. e reduction of estrogen and its receptors in perimenopausal patients can also lead to dysfunction of the hypothalamic-pituitary-ovarian axis, and insomnia is one of the most common symptoms [22]. Sleep disorders not only affect the quality of life of women in the perimenopausal and postmenopausal periods but also endanger their lives and health in the long run, causing social burdens [23].…”

Section: Discussionmentioning

confidence: 99%

A Clinical Study of the Effect of Estradiol Valerate on Sleep Disorders, Negative Emotions, and Quality of Life in Perimenopausal Women

Zhang¹,

Shao²,

Ye³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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In this prospective study, we randomly divided 100 patients with perimenopausal syndrome equally into the control group (n = 50) receiving conventional treatment and the study group (n = 50) receiving estradiol valerate. The indicators observed were endometrial thickness, uterine volume, and the levels of LH (luteinizing hormone), FSH (follicle-stimulating hormone), and E2 (estradiol) of the patients before and after treatment. The Pittsburgh Sleep Quality Index (PSQI), Hamilton Anxiety/Depression Scale (HAMA/HAMD), Kupperman symptom score, and menopause-specific quality of life (MENQOL) were also applied to assess the sleep quality, negative emotions, severity of the condition, and quality of life of all patients, respectively. Our findings were that estradiol valerate is beneficial in improving serum sex hormone levels, sleep disturbances, negative mood, and quality of life in patients with perimenopausal syndrome and that its safety profile is high enough to warrant clinical promotion.

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Section: Discussionmentioning

confidence: 99%

A Clinical Study of the Effect of Estradiol Valerate on Sleep Disorders, Negative Emotions, and Quality of Life in Perimenopausal Women

Zhang¹,

Shao²,

Ye³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Different countries were included in this review. Four studies were conducted in Spain ( 15 , 16 , 18 , 19 ), two each in Ecuador ( 13 , 20 ), Turkey ( 21 , 22 ), Korea ( 23 , 24 ), and China ( 25 , 26 ), and one each in India ( 27 ), Bangladesh ( 28 ), Saudi Arabia ( 29 ), the United States ( 30 ), Oman ( 31 ), Africa ( 32 ), Finland ( 17 ), Israel ( 33 ), Japan ( 34 ), Russia ( 35 ), Chile ( 36 ), Brazil ( 37 ), Poland ( 38 ), Italy ( 39 ), Nepal ( 40 ), Singapore ( 14 ), and Jordan ( 12 ). The smallest sample size was 187 ( 27 ) and the largest 2,886 ( 34 ).…”

Section: Resultsmentioning

confidence: 99%

“…In this meta-analysis, the pooled prevalence of premenopausal, perimenopausal, and post-menopausal women was 35.5, 24.18, and 45.49%, respectively. The wide range of prevalence for each of the three menopausal stages was due to the different study settings, where 21 ( 12 , 13 , 15 , 16 , 18 – 24 , 27 , 29 – 31 , 36 – 40 ) studies were conducted in medical centers, and eight ( 14 , 17 , 25 , 28 , 32 – 35 ) were in the community. Methodological techniques such as sampling methods and tools, together with study implementation may also account for differences in estimated prevalence among studies.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Psychosomatic and Genitourinary Syndrome Among Menopausal Women: A Systematic Review and Meta-Analysis

et al. 2022

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IntroductionThe menopausal transition represents the passage from reproductive to non-reproductive life and is characterized by a number of menstrual disturbances. We systematically reviewed the evidence on the prevalence of psychosomatic and genitourinary syndrome among menopausal women and compared the risk of symptoms between premenopausal, perimenopausal, and post-menopausal women.MethodsWe performed a systematic search in MEDLINE, CINAHL, and ScienceDirect through March 2021. Case series/reports, conference papers and proceedings, articles available only in abstract form, editorial reviews, letters of communication, commentaries, systematic reviews, and qualitative studies were excluded. Two reviewers independently extracted and assessed the quality of data using the Joanna Briggs Institute Meta-Analysis. The outcomes were assessed with random-effects model using the Review Manager software.ResultsIn total, 29 studies had a low risk of bias and were included in the review. Our findings showed that the pooled prevalence of somatic symptoms in post-menopausal women (52.6%) was higher than in the premenopausal and perimenopausal stages (34.6 and 39.5%, respectively). There was a low prevalence of psychological symptoms in premenopausal women (28.4%). The genitourinary syndrome was highest among post-menopausal women (55.1%), followed by perimenopausal (31.9%) and premenopausal (19.2%) women.ConclusionPost-menopausal women have a higher risk of experiencing menopausal symptoms particularly genitourinary syndrome than premenopausal and perimenopausal women. It is pertinent for healthcare professionals to evaluate the symptoms in order to provide them with a better quality of life.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021235958

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“…Perimenopausal insomnia is associated with subjective factors such as anxiety and depression, as well as objective factors such as income and education environment [12–13] . Insomnia is the core symptom of perimenopause, the prevalence of sleep disorders increases significantly during and after menopause [14–18] .…”

Section: Discussionmentioning

confidence: 99%

Tuina for perimenopausal insomnia

Zhi

Zhang

et al. 2022

Medicine

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Background: Insomnia in perimenopausal women has a negative impact on quality of life and increases health care costs. With the increasing incidence of the disease, Tuina has been accepted by perimenopausal women. The purpose of this study is to explore the effectiveness and safety of Tuina for perimenopausal insomnia. Methods: We will search 9 electronic databases: Chinese Biomedical Literature Database, Cochrane Library, China National Knowledge Infrastructure, EMBASE, MEDLINE, Web of Science, PubMed, Wan fang, Chinese Scientific Journal Database, and 1 clinical trials register platform: WHO International Clinical Trials Registry Platform. All relevant randomized controlled trial using Tuina for perimenopausal insomnia will be included. Two reviewers will independently screen date, and meta-analysis will be performed with RevMan (V5.3.5) software. Results: This study will provide an evidence of Tuina for perimenopausal insomnia. Conclusion: This study will provide a reliable evidence for the evaluation of the efficacy and side effects of Tuina in the treatment of perimenopausal insomnia. PROSPERO registration number: CRD42021259017. Ethics and dissemination: This systematics review will evaluate the efficacy and safety of tuina in the treatment of perimenopausal insomnia. Since all the data included were published, the systematic review did not require ethical approval.

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Insomnia symptoms in relation to menopause among middle-aged Chinese women: Findings from a longitudinal cohort study

Cited by 26 publications

References 27 publications

A Clinical Study of the Effect of Estradiol Valerate on Sleep Disorders, Negative Emotions, and Quality of Life in Perimenopausal Women

A Clinical Study of the Effect of Estradiol Valerate on Sleep Disorders, Negative Emotions, and Quality of Life in Perimenopausal Women

Prevalence of Psychosomatic and Genitourinary Syndrome Among Menopausal Women: A Systematic Review and Meta-Analysis

Tuina for perimenopausal insomnia

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