Insomnia with Objective Short Sleep Duration is Associated with a High Risk for Hypertension

Vgontzas, Alexandros N.; Liao, Duanping; Bixler, Edward O.; Chrousos, George P.; Vela‐Bueno, Antonio

doi:10.1093/sleep/32.4.491

Cited by 663 publications

(568 citation statements)

References 33 publications

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“…For example, sleep duration has been prospectively associated with weight gain, while poor sleep quality has been associated with metabolic syndrome, hypertension, and coronary heart disease. [14][15][16][17][18][19] Neuroendocrine changes caused by poor sleep partially account for these relationships, 20 but behavioral factors related to sleep disturbance, such as decreased physical activity, may also play a role.…”

Section: S C I E N T I F I C I N V E S T I G a T I O N Smentioning

confidence: 99%

The Mediating Effect of Sleep Quality on the Relationship between PTSD and Physical Activity

Talbot

Neylan

Metzler

et al. 2014

Journal of Clinical Sleep Medicine

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Study Objectives: Physical inactivity is linked to health outcomes such as obesity, diabetes, and psychiatric disorders. Sleep disturbance has been linked to the same adverse outcomes. We examine the infl uence of sleep on physical activity as a novel approach to understand these relationships. Specifi cally, our objective was to determine whether low sleep quality predicts low physical activity in posttraumatic stress disorder (PTSD), a disorder associated with sleep disturbance, physical inactivity, and poor health outcomes. Methods: We used data from the Mind Your Heart Study, a prospective cohort study of 736 outpatients recruited from two Department of Veterans Affairs (VA) medical centers. We assessed PTSD with the Clinician Administered PTSD Scale, sleep quality using an item from the Pittsburgh Sleep Quality Index, and physical activity by self-report at baseline and again one year later. Hierarchical multiple regression models and structural equation modeling were used to examine the relationships among PTSD, sleep, and physical activity. Results: Sleep quality but not PTSD status was prospectively associated with lower physical activity in a model adjusting for age, sex, apnea probability, depression, body mass index, and baseline physical activity (β = 0.129, SE = 0.072, p < 0.01). Structural equation modeling indicated that the results were consistent with sleep quality statistically mediating the relationship between PTSD status at baseline and physical activity one year later. Conclusions: Worse sleep quality predicts lower physical activity in PTSD, providing possible evidence for a behavioral pathway from disturbed sleep to poor physical health outcomes. Keywords: posttraumatic stress disorder, sleep quality, physical activity Citation: Talbot LS, Neylan TC, Metzler TJ, Cohen BE. The mediating effect of sleep quality on the relationship between PTSD and physical activity. J Clin Sleep Med 2014;10(7):795-801.

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Section: S C I E N T I F I C I N V E S T I G a T I O N Smentioning

confidence: 99%

The Mediating Effect of Sleep Quality on the Relationship between PTSD and Physical Activity

Talbot

Neylan

Metzler

et al. 2014

Journal of Clinical Sleep Medicine

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“…Insomnia disorder with objective short sleep durationis associated with increasing incidence of hypertension and negatively impacts the variability of blood pressure and heart rate, which has been associated with increased cardiovascular mortality 5,6,7 . A cross-sectional analysis revealed that insomnia with objective short sleep duration is associated with an increased risk of diabetes 8 .…”

mentioning

confidence: 99%

Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia

D’Aurea¹,

Poyares²,

Piovezan³

et al. 2015

Arq. Neuro-Psiquiatr.

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Objective To evaluate the association between objective short sleep duration in patients with insomnia and changes in blood parameters related to hypothalamic-pituitary-adrenal (HPA) axis activity.Method A cross-sectional pilot study was conducted in 30 middle-aged adults with chronic insomnia who were divided into 2 groups according to polysomnography (PSG) total sleep time (TST) (TST > 5h and < 5h). All patients underwent subjective analysis of sleep quality, anthropometric measurements, PSG, and determination off asting blood parameters.Results The results revealed lower sleep efficiency and higher sleep latency for those with a TST < 5h. The subjective sleep quality was worse in the TST < 5h. Significantly, higher glucose and cortisol levels were observed with a TST < 5h. Glucose, cortisol and ACTH levels were inversely correlated with the PSG total sleep time.Conclusion Patients with insomnia with objective short sleep duration had HPA-associated endocrine and metabolic imbalances chronically linked to increases in cardiovascular risk observed with this more severe insomnia phenotype.

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“…Patients with fatigue were more likely to be institutionalized and had increased mortality in the subsequent year. 101 In some studies, delirium was reported in up to half of patients, especially in the first week after ischemic stroke. 102,103 This delirium can prolong hospital stay and increases risk of dementia and admission to an institution.…”

Section: Obstructive Sleep Apnea and Rehabilitation Outcomementioning

confidence: 99%

Rehabilitation of Cardiovascular Disorders and Sleep Apnea

Jafari

2017

Sleep Medicine Clinics

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Insomnia with Objective Short Sleep Duration is Associated with a High Risk for Hypertension

Cited by 663 publications

References 33 publications

The Mediating Effect of Sleep Quality on the Relationship between PTSD and Physical Activity

The Mediating Effect of Sleep Quality on the Relationship between PTSD and Physical Activity

Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia

Rehabilitation of Cardiovascular Disorders and Sleep Apnea

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