Insomnia

Sutton, Eliza L.

doi:10.7326/aitc202103160

Cited by 144 publications

(67 citation statements)

References 47 publications

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“…In the general population, insomnia is a common health problem, with 19% to 50% of adults having sleep complaints [ 1 ]. Roughly half of insomnia patients who fulfill the diagnostic for for insomnia disorder have a chronic course [ 2 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

The stigma of patients with chronic insomnia: a clinical study

et al. 2022

BMC Psychiatry

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Background The objective of this study was to explore the stigma and related influencing factors in individuals with chronic insomnia disorder (CID). Methods A total of 70 CID patients and 70 healthy controls (CON) were enrolled in the study. All subjects completed the assessments of sleep, emotion, and cognition. Their stigma and life quality were measured using the Chronic Stigma Scale and the 36-Item Short-Form Health Survey (SF-36). Results The ratio of individuals with stigma was significantly different between CID and CON groups (C2 = 35.6, p < 0.001). Compared with the CON group, the CID group had higher scores for total stigma (U = 662.0, p < 0.001), internalized stigma (U = 593.0, p < 0.001), enacted stigma (U = 1568.0, p < 0.001), PSQI (U = 2485.0, p < 0.001) and HAMD-17 (U = 69.5, p < 0.001) as well as lower scores for MoCA-C (U = 3997.5, p < 0.001) and most items of SF-36. Partial correlation analysis showed that different items of the Chronic Stigma Scale were positively correlated with illness duration, PSQI and HAMD-17 scores, while negatively correlated with one or more items of the SF-36. Multivariate regression analysis showed that illness duration and the Mental Health domain of the SF-36 were independent risk factors for one or more items of stigma in CID patients. Conclusion Patients with CID have an increased risk of stigma. Moreover, illness duration and Mental Health may be primary factors related to stigma.

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Section: Introductionmentioning

confidence: 99%

The stigma of patients with chronic insomnia: a clinical study

et al. 2022

BMC Psychiatry

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“…Insomnia is a syndrome defined as difficulty in falling asleep, maintaining sleep, or non-restorative sleep [ 14 ]. There is a bidirectional relationship between insomnia and mood symptoms, poor sleep may precede the episode of MDD, and depressed mood disrupt standard sleep patterns [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Insomnia is the main symptom of several common sleep disorders, but it often coexists with mental illnesses. In addition, insomnia can affect the trajectory of MDD and increase the severity and duration of this disorder [ 14 ]. The poor subjective sleep quality before the treatment of MDD may indicate a reduced treatment response.…”

Section: Discussionmentioning

confidence: 99%

Effect of insomnia in the major depressive disorder

et al. 2022

BMC Neurol

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Background People with sleep problems are more likely to have mental disorders. This study aimed to assess the effect of insomnia on the prognosis of patients with major depressive disorder (MDD). Methods We divided the patients into three groups according to the Insomnia Severity Index (ISI) scores. In addition, we compared the results of the Hamilton Depression Scale (HAMD) and Symptom Checklist-90 (SCL-90) scores. We evaluated the effect of insomnia at the 2nd, 4th, and 8th-week follow-up on the prognosis of MDD. Results Fifty-five patients between 19 and 58 years old, with a diagnosis of MDD via the Structured Clinical Interview for the Diagnostic and Statistical Manual-5 (DSM-5). The ISI scores of the moderate and severe group decreased significantly (P < 0.05) in the 2nd week compared to the baseline. The HAMD scores in all groups improved significantly in the 2nd week. Conclusions This study was inspired to assess insomnia as a comorbid disorder for patients with MDD, which may bring poor treatment consequences.

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“…Insomnia is a public health problem and one of the most frequent sleep disorders in patients with other neurological disorders ( Sutton, 2021 ). This disorder is characterized by difficulties in guaranteeing sleep quality, initiating or maintaining sleep, and severe distress and impairment of daytime functioning ( Bollu and Kaur, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

B serum proteome profiles revealed dysregulated proteins and mechanisms associated with insomnia patients: A preliminary study

Liu

Wang

Zhang

et al. 2022

Front. Integr. Neurosci.

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BackgroundInsomnia is a clinical problem of significant public health importance; however, the underlying pathogenesis of this disorder is not comprehensively understood.MethodsTo identify potential treatment targets and unfold one of the gaps that were involved in insomnia pathological mechanisms, we employed a tandem mass tag-based (TMT) quantitative proteomics technology to detect differentially expressed proteins (DEPs) in serum from patients with insomnia and controls. DEPs were further analyzed by bioinformatics platforms. In addition, parallel reaction monitoring (PRM) was used to verify the TMT results.ResultsPatients with insomnia had poorer sleep quality compared with healthy controls. A total of 106 DEPs were identified among patients with insomnia and controls. They were mainly enriched in immune and inflammation-related biological functions and signaling pathways. Using the protein–protein interaction network, we screened the 10 most connected proteins as key DEPs. We predicted that four key DEPs were subject to targeted regulation by natural compounds of herbs. Eight key DEPs were validated using PRM in an additional 15 patients with insomnia and 15 controls, and the results also supported the experimental findings.ConclusionWe identified aberrantly expressed proteins in insomnia that may be involved in the immune-inflammatory response. The 10 key DEPs screened may be potential targets for insomnia, especially FN1, EGF, HP, and IGF1. The results of this study will broaden our understanding of the pathological mechanisms of insomnia and provide more possibilities for pharmacotherapy.

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Insomnia

Cited by 144 publications

References 47 publications

The stigma of patients with chronic insomnia: a clinical study

The stigma of patients with chronic insomnia: a clinical study

Effect of insomnia in the major depressive disorder

B serum proteome profiles revealed dysregulated proteins and mechanisms associated with insomnia patients: A preliminary study

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