Insomnio pediátrico: clínica, diagnóstico y tratamiento

Miano, Silvia; Peraita-Adrados, Rosa

doi:10.33588/rn.5801.2013398

Cited by 2 publications

(2 citation statements)

References 31 publications

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“…According to a report by the World Health Organization, about 1/3 of the world's population suffers from sleep disorders, and the percentage in the Chinese population, which is 27%, is significantly higher than the average levels worldwide [1]. Insomnia also leads to diseases such as hypertension, low immune function and diabetes.…”

Section: Introductionmentioning

confidence: 99%

iTRAQ-based proteomics analysis on insomnia rats treated with Mongolian medical warm acupuncture

Man

et al. 2020

Bioscience Reports

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Objective: To explore the proteomic changes in the hypothalamus of rats treated with Mongolian medical warm acupuncture for insomnia therapy based proteomics. Method: We used an iTRAQ-based quantitative proteomic approach to identify proteins that potential molecular mechanisms involved in the treatment of insomnia by Mongolian medical warm acupuncture. Result: In total, 7477 proteins were identified, of which 36 proteins showed increased levels and 45 proteins showed decreased levels in insomnia model group (M) compared with healthy control group (C), 72 proteins showed increased levels and 44 proteins showed decreased levels from the warm acupuncture treated insomnia group (W) compared with healthy controls (C), 28 proteins showed increased levels and 17 proteins showed decreased levels from the warm acupuncture-treated insomnia group (W) compared with insomnia model group (M). Compared with healthy control groups, warm acupuncture-treated insomnia group showed obvious recovered. Bioinformatics analysis indicated that up-regulation of neuroactive ligand–receptor interaction and oxytocin signaling was the most significantly elevated regulate process of Mongolian medical warm acupuncture treatment for insomnia. Proteins showed that increased/decreased expression in the warm acupuncture-treated insomnia group included Prolargin (PRELP), NMDA receptor synaptonuclear-signaling and neuronal migration factor (NSMF), Transmembrane protein 41B (TMEM41B) and Microtubule-associated protein 1B (MAP1B) to adjust insomnia. Conclusion: A combination of findings in the present study suggest that warm acupuncture treatment is efficacious in improving sleep by regulating the protein expression process in an experimental rat model and may be of potential benefit in treating insomnia patients with the added advantage with no adverse effects.

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Section: Introductionmentioning

confidence: 99%

iTRAQ-based proteomics analysis on insomnia rats treated with Mongolian medical warm acupuncture

Man

et al. 2020

Bioscience Reports

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“…While specific sleep disorders are a frequent comorbid condition associated with ADHD according to a categorical approach, they can also induce ADHD-like symptoms if considered dimensionally and are thought to be the consequence of EDS. Given the complexity of the interaction between ADHD and sleep, the team of Miano (93)(94)(95) identified five sleep phenotypes in ADHD: a sleep phenotype characterized by a hypo-arousal state "narcolepsy-like," another associated with delayed sleep onset latency, a phenotype related with sleep-disordered breathing, another associated with restless legs syndrome and/ or PLMD, and a phenotype related to epilepsy/or EEG interictal discharges.…”

Section: Excessive Daytime Sleepiness In Children With Adhdmentioning

confidence: 99%

Excessive Daytime Sleepiness Measurements in Children With Attention Deficit Hyperactivity Disorder

et al. 2020

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Attention deficit hyperactivity disorder (ADHD) is the most commonly diagnosed neurodevelopmental disorder in childhood. It is a heterogeneous disorder in terms of clinical presentation that is probably due to the frequent occurrence of comorbidity. Children with ADHD more frequently report sleep disorders (notably delayed sleep phase syndrome) and excessive daytime sleepiness (EDS) than typically developing children. The aim of this article is to propose a narrative review of the assessment of EDS in the context of ADHD with first a summary of the subjective and objective tools used to measure it. Secondly, perspectives in terms of electroencephalogram (EEG) markers and neurofeedback are proposed. Then, possibilities for new kinds of evaluation are discussed (virtual reality, ecological momentary assessment, etc.). Lastly, we discuss specific clinical situations with EDS in the context of ADHD as links with narcolepsy, the comorbidity with other psychiatric disorders, and the context of sluggish cognitive tempo.

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Insomnio pediátrico: clínica, diagnóstico y tratamiento

Cited by 2 publications

References 31 publications

iTRAQ-based proteomics analysis on insomnia rats treated with Mongolian medical warm acupuncture

iTRAQ-based proteomics analysis on insomnia rats treated with Mongolian medical warm acupuncture

Excessive Daytime Sleepiness Measurements in Children With Attention Deficit Hyperactivity Disorder

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