Inspection and Remedy of Cervical Cancer Using Nanoparticles

Cervical cancer: a meta-analysis, therapy and future of nanomedicine

“…The use of nanotechnology in pharmaceutical research and development of novel medical approaches has been precluded as a key enabling technology, which enhances the development of innovative medical solutions to address unfulfilled medical needs [ 74 , 75 ]. The application of nanotechnology for medical purposes has been termed as nanomedicine and is defined as the use of nanomaterials to diagnose, treat, monitor and control diseases [ 12 ].…”

“…A fourth emerging category, which combines therapy and diagnostics, termed theranostics displays a promising approach for future cancer therapy [ 79 , 80 ]. Nanomedicine has revolutionised clinical practices by exploiting multiple mechanisms of effective molecules which could not be utilised to date due to their toxicity, maximising efficacy and reducing harmful side effects, toxicity and required dose [ 12 – 14 ]. Nanoparticles provide a preferential distribution throughout the body by facilitating targeted, controlled and site-specific drug delivery, in addition to improving movement across biological barriers [ 80 ].…”

“…AgNPs upregulated the mRNA expression of BAX, P53 and caspase 3 in AgNP-treated HeLa cells by targeting the mitochondrial apoptotic pathways. Nanomedicine has revolutionised gene therapy, chemotherapy and photodynamic therapy by improving the delivery of insoluble drugs, circulation, direct targeting or delivery of drugs, delivery of multiple drugs and transcytosis of the drugs across endothelial and epithelial barriers and imaging [ 12 , 91 ].…”

“…However, these therapies are limited by a lack of anticancer drug potency, non-specificity, negative side effects and the development of MDR, which leads to a decrease in the long-term efficacy of anticancer therapy [ 11 ]. Nanotechnology has the potential to overcome these limitations, by increasing the selectivity and potency of chemical, physical and biological approaches for eliciting cancer cell death whilst minimising collateral toxicity to non-malignant cells [ 12 , 13 ]. The favourable and unique properties of nanoparticles can improve the delivery of therapeutics, thereby enhancing their activity in cervical cancer cells whilst reducing harmful side effects in healthy cells [ 14 , 15 ].…”