Inspiratory Airflow Dynamics During Sleep in Women with Fibromyalgia

Gold, Avram R.; Dipalo, Francis; Gold, Morris S.; Broderick, Joan E.

doi:10.1093/sleep/27.3.459

Cited by 97 publications

(38 citation statements)

References 28 publications

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“…In our study, we found OSAS frequency in female patients to be 10.5%. Although our study yielded similar results to those of Moldofsky et al, 33 the difference could be attributed to the fact that the patients in our study were younger, had lower BMI, and were only females.…”

Section: Discussionsupporting

confidence: 83%

“…In their study, May et al 32 found OSAS frequency in female patients with FMS as insignificant, while they found this frequency as significant in male patients with FMS, which led them to conclude that further research must be performed on male patients in terms of OSAS risk. Moldofsky et al 33 found moderate to severe obstructive sleep apnea disorder frequency to be 15.3%. In our study, we found OSAS frequency in female patients to be 10.5%.…”

Section: Discussionmentioning

confidence: 98%

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Decrease of Serum IGF-1 Level is Not Associated With Obstructive Sleep Apnea in Fibromyalgia Patients

Hayta

Oksasoglu

2017

Arch Rheumatol

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Objectives: This study aims to investigate the relationship of serum insulin-like growth factor 1 (IGF-1) level with obstructive sleep apnea, the Pittsburgh sleep quality index (PSQI), age, body mass index, and fibromyalgia impact questionnaire (FIQ) in fibromyalgia syndrome (FMS) patients. Patients and methods: A total of 105 female patients (mean age 41.8±9.0 years; range 26 to 55 years) with fibromyalgia (FMS group) who were diagnosed according to 2010 American College of Rheumatology criteria, and 51 female patients (mean age 39.9±10.8 years; range 24 to 54 years) with mechanical low back pain (MLBP) (control group) were included in the study. Age, smoking, educational status, tender point number, body mass index, duration of disease, FIQ, PSQI, and polysomnographic assessment of both FMS and control groups were recorded. Results: Sleep disorder was detected in 88 patients in FMS group and 15 patients in control group (p<0.05). The PSQI score was higher in the FMS group compared to the control group (9.9±4.6 vs 5.7±3.5). The FIQ score was higher in the FMS group compared to the control group (53.4±17.4 vs 26.4±13.9; p<0.05). The serum IGF-1 level of FMS group was significantly lower than that of the control group (140.6±49.5 ng/mL vs 177.2±58.5 ng/mL; p<0.05). In the FMS group, an examination of the correlation between serum IGF-1 level with the age, body mass index, obstructive sleep apnea syndrome, FIQ, and PSQI revealed a negative correlation between serum IGF-1 with the age and PSQI. The obstructive sleep apnea syndrome ratios of study groups were comparable with regard to the frequencies of mild, moderate, and severe obstructive sleep apnea syndrome. Conclusion: In FMS patients, serum IGF-1 levels may decrease due to age and PSQI; however, this may not be related to the severity of obstructive sleep apnea.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 98%

Decrease of Serum IGF-1 Level is Not Associated With Obstructive Sleep Apnea in Fibromyalgia Patients

Hayta

Oksasoglu

2017

Arch Rheumatol

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“…The similarity of these findings in women with TMD to PSG evaluations of women with fibromyalgia showing increased sleep disruption and inspiratory flow limitation without elevated AHI underscores pain-related arousability as a possible cause of elevated RERA index in TMD. 31,32 It has been suggested that a lower arousal threshold in response to respiratory stimuli may contribute to the etiology of sleep disordered breathing, 33 and elevating the arousal threshold with a hypnotic may reduce the frequency of respiratory events. 34 Therefore, the role of chronic pain conditions in lowering the arousal threshold to respiratory stimuli during sleep needs to be determined in future studies.…”

Section: Pain and Covariate Predictorsmentioning

confidence: 99%

Polysomnographic Investigation of Sleep and Respiratory Parameters in Women with Temporomandibular Pain Disorders

Dubrovsky

Raphael

Lavigne

et al. 2014

Journal of Clinical Sleep Medicine

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Study Objectives: Temporomandibular pain disorders (TMD) and myofascial pain were linked to increased prevalence of insomnia and obstructive sleep apnea (OSA) on clinical grounds. However, the literature lacks an accurate polysomnographic (PSG) characterization of sleep abnormalities associated with TMD, given that prior studies included small or uncontrolled samples of TMD patients. The present investigation aims to objectively evaluate measures of sleep and respiratory disturbance in a large representative sample of TMD cases in comparison with matched controls. Methods: Sleep, respiration, and limb movements were measured using a 2-night attended PSG protocol in 170 women-124 TMD cases with myofascial pain and 46 demographically matched controls. The second night data were compared between the groups using ANCOVAs. In TMD cases, the relationship between pain ratings and sleep parameters was analyzed using multiple regressions. Results: In comparison to healthy controls, TMD cased evidenced a signifi cant increase in stage N1 sleep (12.2% ± 7.6% vs. 9.2% ± 5.0%, p = 0.03), which was only mild relative to normative values. TMD cases also demonstrated mild but signifi cant elevations in arousals associated with all types of respiratory events (6.0/h ± 6.1 vs. 3.5/h ± 3. S C I E N T I F I C I N V E S T I G A T I O N ST emporomandibular disorders (TMD), most often characterized by painful musculoskeletal signs and symptoms in the masticatory region, is a pain syndrome estimated to affect approximately 5% to 15% of the population, predominantly women.1-4 Subjective sleep disturbance has been consistently reported in TMD patients. 5,6 Two earlier polysomnographic (PSG) studies failed to demonstrate objective differences in sleep or respiratory measures between TMD cases with myofascial pain and control participants free from myofascial pain and signs of TMD; however, the small sample sizes and restrictive selection criteria limit their interpretability. 7,8 A recent investigation employing PSG recordings and clinical sleep interviews in an uncontrolled sample of TMD cases showed that TMD is associated with primary sleep disorders, such as insomnia and obstructive sleep apnea (OSA): nearly 36% of TMD cases met diagnostic criteria for insomnia, and over 28% met criteria for OSA. 9 In the same sample of TMD cases, sleep effi ciency on PSG was directly related to a measure of pain threshold, suggesting an association between pain and sleep disturbance in TMD.9,10 Additionally, a high prevalence of TMD was reported in clinical patients with mild to moderate OSA referred for a clinical dental evaluation, lending further support to the association between TMD and OSA.11 It was BRIEF SUMMARYCurrent Knowledge/Study Rationale: A relationship between temporomandibular pain disorders (TMD) and sleep and respiratory disturbance has been suggested; however, large-scale controlled polysomnographic studies are lacking. The present investigation used two-night polysomnography to measure sleep architecture and respiration in a large...

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“…(17) Still others, in 2004, found SDB in 27 of 28 women with FMS. (18) However, in various other studies involving larger study samples, no association between FMS and SDB has been observed. (25)(26)(27)(28) Our finding that alpha activity increased during delta sleep in 5 of the 11 cases of FMS is consistent with that of other authors, who observed alphadelta sleep in 20 out of 40 women with FMS.…”

Section: Discussionmentioning

confidence: 90%

“…(17) Another reported fourteen cases of FMS symptom improvement in patients with SDB after three weeks of continuous positive airway pressure. (18) These findings suggest that SDB plays a role in the development of FMS.…”

Section: Introductionmentioning

confidence: 85%

Coexistência de transtornos respiratórios do sono e síndrome fibromiálgica

Germanowicz

Lumertz²,

Martinez

et al. 2006

J. bras. pneumol.

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Objective: To identify fibromyalgia syndrome in patients with sleep disordered breathing. Method: We studied 50 patients seeking treatment at a sleep disorder clinic for snoring, apnea and excessive daytime sleepiness. Sleep disordered breathing was diagnosed through the use of polysomnography. To diagnose fibromyalgia syndrome, patients were evaluated in accordance with the criteria established by the American College of Rheumatology. Results: Of the 50 patients, 32 were male. The mean (± standard deviation) age of the group was 50 ± 12 years. The mean body mass index was 29.7 ± 5.6 kg/m 2 . The mean apnea-hypopnea index was 36 ± 29 attacks of apnea or hypopnea per hour of sleep. Of the 18 women and 32 men evaluated, 9 and 2, respectively, met the American College of Rheumatology criteria for fibromyalgia syndrome. Conclusion: Considering the fact that the prevalence of fibromyalgia syndrome in the general population is 0.5% for men and 3.4% for women, the more than ten-fold higher proportion of fibromyalgia cases seen in this sample supports the hypothesis that there is an association between sleep disordered breathing and fibromyalgia syndrome.

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Inspiratory Airflow Dynamics During Sleep in Women with Fibromyalgia

Abstract: Inspiratory airflow limitation is a common inspiratory airflow pattern during sleep in women with fibromyalgia. Our findings are compatible with the hypothesis that inspiratory flow limitation during sleep plays a role in the development of the functional somatic syndromes.

Cited by 97 publications

References 28 publications

Decrease of Serum IGF-1 Level is Not Associated With Obstructive Sleep Apnea in Fibromyalgia Patients

Decrease of Serum IGF-1 Level is Not Associated With Obstructive Sleep Apnea in Fibromyalgia Patients

Polysomnographic Investigation of Sleep and Respiratory Parameters in Women with Temporomandibular Pain Disorders

Coexistência de transtornos respiratórios do sono e síndrome fibromiálgica

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