Inspiratory muscle function in asthmatic and healthy subjects: influence of age, nutrition and physical activity

Heinzmann‐Filho, João Paulo; Vendrusculo, Fernanda Maria; Woszezenki, Cristhiele Taís; Piva, Taila Cristina; Santos, Andressa Nunes; Barcellos, Andressa Bombardi; Vagliatti, Bruna Brufatto; Correa, D.; Mattiello, Rita; Donadio, Márcio Vinı́cius Fagundes

doi:10.3109/02770903.2016.1165698

Cited by 16 publications

(29 citation statements)

References 45 publications

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“…Additionally, the variations in MEP/MIP ratio was mostly due to changes in the magnitude of the strength of inspiratory muscles. These results are in accordance with those from studies carried out in patients with other chronic pulmonary diseases, 7,17,[33][34][35] which have revealed the existence of weakness of inspiratory muscles associated to the induction of mechanisms of oxidative stress, apoptosis, and inspiratory muscular atrophy. 1,2,36 Although there are no data regarding potential mechanisms underlying the functional deterioration observed in patients with PIBO, some studies observe a high level of oxidative stress in lung parenchyma, [37][38][39] suggesting the possibility that inspiratory muscle weakness seen in these patients may be associated to oxidative mechanisms similar to those observed in patients with chronic obstructive pulmonary disease (COPD).…”

Section: Discussionsupporting

confidence: 91%

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Respiratory Muscle Impairment Evaluated With Mep/Mip Ratio in Children and Adolescents With Chronic Respiratory Disease

Rodríguez‐Núñez

Torres

Luarte-Martínez

et al. 2021

Rev. paul. pediatr.

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Objective: To evaluate the strength of respiratory muscles and to compare maximum inspiratory (MIP) and expiratory (MEP) pressure and MEP/MIP ratio between patients with chronic respiratory diseases and healthy individuals. Methods: Case-control study. Individuals with neuromuscular disease and post-infectious bronchiolitis obliterans were considered. In addition, they were also matched according to anthropometric and demographic characteristics with healthy children and adolescents. MIP, MEP in the three groups, and pulmonary function only in patients with chronic respiratory diseases were recorded. Results: A total of 52 subjects with CRD (25 with neuromuscular disease, and 27 with post-infectious bronchiolitis obliterans) and 85 healthy individuals were included, with an average age of 11.3±2.1 years. Patients with neuromuscular disease and post-infectious bronchiolitis obliterans presented lower MIP and MEP when compared with healthy individuals, although MEP/MIP ratio was lower in patients with neuromuscular disease (0.87±0.3) and higher in patients with post-infectious bronchiolitis obliterans (1.1±0.3) compared to the healthy group (0.97±0.2). Only in patients with neuromuscular disease a negative correlation was observed between MEP/MIP ratio and age (r=-0.50; p=0.01). Conclusions: Differences in the pattern of muscular weakness between patients with chronic respiratory diseases were observed. In patients with neuromuscular disease, a decrease in the MEP/MIP ratio depending on MIP was verified; and in those patients with post-infectious bronchiolitis obliterans, an increase in the MEP/MIP ratio depending on MIP was also observed.

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Section: Discussionsupporting

confidence: 91%

“…The magnitude of deterioration is similar to that observed in other chronic pulmonary diseases. 6,32,33 In addition, patients with PIBO experienced a higher MEP/ MIP ratio compared to patients with NMD (p<0.05). Additionally, the variations in MEP/MIP ratio was mostly due to changes in the magnitude of the strength of inspiratory muscles.…”

Section: Discussionmentioning

confidence: 96%

Respiratory Muscle Impairment Evaluated With Mep/Mip Ratio in Children and Adolescents With Chronic Respiratory Disease

Rodríguez‐Núñez

Torres

Luarte-Martínez

et al. 2021

Rev. paul. pediatr.

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“…The results of studies involving inspiratory muscle strength in asthmatic children and adolescents are conflicting. Some studies show that there is no difference, 25 26 and other studies show that the strength of the inspiratory muscles of children and adolescents with asthma is reduced relative to their peers. 27 Similar results were observed in inspiratory muscle endurance.…”

Section: Discussionmentioning

confidence: 99%

Echocardiographic Assessment of Ventricular Function in Young Patients with Asthma

De-Paula¹,

Magalhães²,

Jentzsch³

et al. 2018

Arquivos Brasileiros De Cardiologia

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BackgroundDespite significant advances in understanding the pathophysiology and management of asthma, some of systemic effects of asthma are still not well defined.ObjectivesTo compare heart function, baseline physical activity level, and functional exercise capacity in young patients with mild-to-moderate asthma and healthy controls.MethodsEighteen healthy (12.67 ± 0.39 years) and 20 asthmatics (12.0 ± 0.38 years) patients were enrolled in the study. Echocardiography parameters were evaluated using conventional and tissue Doppler imaging (TDI).ResultsAlthough pulmonary acceleration time (PAT) and pulmonary artery systolic pressure (PASP) were within normal limits, these parameters differed significantly between the control and asthmatic groups. PAT was lower (p < 0.0001) and PASP (p < 0.0002) was higher in the asthma group (114.3 ± 3.70 ms and 25.40 ± 0.54 mmHg) than the control group (135.30 ± 2.28 ms and 22.22 ± 0.40 mmHg). The asthmatic group had significantly lower early diastolic myocardial velocity (E', p = 0.0047) and lower E' to late (E'/A', p = 0.0017) (13.75 ± 0.53 cm/s and 1.70 ± 0.09, respectively) compared with control group (15.71 ± 0.34 cm/s and 2.12 ± 0.08, respectively) at tricuspid valve. In the lateral mitral valve tissue Doppler, the asthmatic group had lower E' compared with control group (p = 0.0466; 13.27 ± 0.43 cm/s and 14.32 ± 0.25 cm/s, respectively), but there was no statistic difference in the E'/A' ratio (p = 0.1161). Right isovolumetric relaxation time was higher (p = 0.0007) in asthmatic (57.15 ± 0.97 ms) than the control group (52.28 ± 0.87 ms), reflecting global myocardial dysfunction. The right and left myocardial performance indexes were significantly higher in the asthmatic (0.43 ± 0.01 and 0.37 ± 0.01, respectively) compared with control group (0.40 ± 0.01 and 0.34 ± 0.01, respectively) (p = 0.0383 and p = 0.0059, respectively). Physical activity level, and distance travelled on the six-minute walk test were similar in both groups.ConclusionChanges in echocardiographic parameters, evaluated by conventional and TDI, were observed in mild-to-moderate asthma patients even with normal functional exercise capacity and baseline physical activity level. Our results suggest that the echocardiogram may be useful for the early detection and evoluation of asthma-induced cardiac changes.

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“…The presence and distribution of subcutaneous fat mass was not associated with any respiratory outcome [26]. There is also evidence that inspiratory muscle endurance is reduced in asthmatic obese or overweight adolescents [27].…”

Section: Lung Functionmentioning

confidence: 97%

Asthma and Obesity during Childhood: A Review of More than an Occasional Association

Rocha¹,

Machado²

2017

J Preg Child Health

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Inspiratory muscle function in asthmatic and healthy subjects: influence of age, nutrition and physical activity

Abstract: Results demonstrate a reduction in the IME in asthmatic adolescents with overweight and obesity, indicating an association between asthma, nutritional status and respiratory muscle function.

Cited by 16 publications

References 45 publications

Respiratory Muscle Impairment Evaluated With Mep/Mip Ratio in Children and Adolescents With Chronic Respiratory Disease

Respiratory Muscle Impairment Evaluated With Mep/Mip Ratio in Children and Adolescents With Chronic Respiratory Disease

Echocardiographic Assessment of Ventricular Function in Young Patients with Asthma

Asthma and Obesity during Childhood: A Review of More than an Occasional Association

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