A meta-analysis including 32 randomised controlled trials on the effects of inspiratory muscle training (IMT) in chronic obstructive pulmonary disease (COPD) patients was performed. Overall and subgroup analyses with respect to training modality (strength or endurance training, added to general exercise training) and patient characteristics were performed. Significant improvements were found in maximal inspiratory muscle strength (PI,max; +13 cmH 2 O), endurance time (+261 s), 6-or 12-min walking distance (+32 and +85 m respectively) and quality of life (+3.8 units). Dyspnoea was significantly reduced (Borg score -0.9 point; Transitional Dyspnoea Index +2.8 units). Endurance exercise capacity tended to improve, while no effects on maximal exercise capacity were found. Respiratory muscle endurance training revealed no significant effect on PI,max, functional exercise capacity and dyspnoea. IMT added to a general exercise programme improved PI,max significantly, while functional exercise capacity tended to increase in patients with inspiratory muscle weakness (PI,max ,60 cmH 2 O).IMT improves inspiratory muscle strength and endurance, functional exercise capacity, dyspnoea and quality of life. Inspiratory muscle endurance training was shown to be less effective than respiratory muscle strength training. In patients with inspiratory muscle weakness, the addition of IMT to a general exercise training program improved PI,max and tended to improve exercise performance.KEYWORDS: Meta-analysis, muscle training, respiratory muscles, systematic review R espiratory muscle weakness is observed in chronic obstructive pulmonary disease (COPD) patients [1, 2] and contributes to hypercapnia [3], dyspnoea [4,5], nocturnal oxygen desaturation [6] and reduced walking distance [7]. During exercise it has been shown that diaphragm work is increased in COPD [8] and COPD patients use a larger proportion of the maximal inspiratory pressure (PI,max) than healthy subjects [9]. This pattern of breathing is closely related to the dyspnoea sensation during exercise [9] and might potentially induce respiratory muscle fatigue. However, diaphragmatic fatigue was not demonstrated after exhaustive exercise [10]. Studies in patients with COPD have shown natural adaptations of the diaphragm to greater oxidative capacity and resistance to fatigue [11][12][13]. The abovementioned considerations gave conflicting arguments to the rationale of respiratory muscle training in COPD. Current guidelines [14,15] and meta-analyses [16][17][18][19][20] are not undisputedly positive on the application of inspiratory muscle training (IMT). From meta-analyses it is clear that IMT increases inspiratory muscle strength and endurance, and decreases dyspnoea. However, exercise performance and quality of life did not improve significantly [18,20,21]. The addition of IMT to a general exercise programme did not improve exercise performance [20]. Furthermore, differences in effects of resistance and endurance training were never analysed, while patient characte...