When the upper airway is bypassed during invasive mechanical ventilation, humidification is necessary to prevent hypothermia, disruption of the airway epithelium, bronchospasm, atelectasis, and airway obstruction. In severe cases, inspissation of airway secretions may cause occlusion of the endotracheal tube. 1 While there is not clear consensus on whether or not additional heat and humidity are always necessary when the upper airway is not bypassed, such as in noninvasive mechanical ventilation (NIV), active humidification is highly suggested to improve comfort. [2][3][4][5][6][7] Two systems, active humidification through a heated humidifier (HH) and passive humidification through a heat and moisture exchanger (HME), are available for warming and humidifying gases delivered to mechanically ventilated patients. There are 3 types of HME or artificial nose: hydrophobic, hygroscopic, and a filtered HME.Heated humidifiers operate actively to increase the heat and water vapor content of inspired gas. 8 HMEs operate passively by storing heat and moisture from the patient's exhaled gas and releasing it to the inhaled gas. 9 The upper airway provides 75% of the heat and moisture supplied to the alveoli. When bypassed, the humidifier needs to supply this missing heat and moisture. Since The authors have disclosed a relationship with Teleflex Medical, which manufactures humidification devices.