In this paper, we are concerned with the instability problem of a 3-D transonic oblique shock wave for the steady supersonic flow past an infinitely long sharp wedge. The flow is assumed to be isentropic and irrotational. It was indicated on p. 317 of [7] that if a steady supersonic flow comes from minus infinity and hits a sharp symmetric wedge, then it follows from the Rankine-Hugoniot conditions and the physical entropy condition that there possibly appears a weak shock or a strong shock attached at the edge of the sharp wedge, which corresponds to a supersonic shock or a transonic shock, respectively. The question arises which of the two actually occurs. It has frequently been stated that the strong one is unstable and that, therefore, only the weak one could occur. However, a convincing proof of this instability has apparently never been given. The aim of this paper is to understand such a longstanding open question. We will show that the attached 3-D transonic oblique shock problem is overdetermined with respect to the periodic perturbation, which implies that the 3-D transonic shock is unstable in general.