This study uses a statistical analysis on given pressure signals to identify the surge condition in radial compressors, providing insight into their dynamics and performance. Specifically, the investigation focuses on a two-stage centrifugal compressor used in refrigeration applications. Through Computational Fluid Dynamics (CFD) Unsteady Reynolds-Averaged Navier-Stokes (URANS) simulations, static pressure time-series are collected to cover four distinct operational points of the machine, ranging from a stable condition to an unstable one. To assess the stability of the compressor operation, the analysis introduces the Approximate Entropy (ApEn) as a statistical parameter to measure the regularity and predictability of the time-series signals. The results show that the proposed methodology is effective in pattern recognition, able to identify sources of instabilities, and to distinguish between different operating conditions. This approach enhances the comprehension of the operational characteristics of centrifugal compressors and sets the stage for improved monitoring and diagnostic methodologies. ApEn can therefore be a useful index to analyse time-series from sensors easy to install in real compressor configurations. The proposed methodology is included in a set of models, based on machine learning techniques, previously developed by the authors, to identify compressor instability during operation.