Instant dentin hypersensitivity relief of a single topical application of an in-office desensitizing paste containing 8% arginine and calcium carbonate: A split-mouth, randomized-controlled study

Kapferer, Ines; Pflug, Claudia; Kisielewsky, Irene; Giesinger, Johannes M.; Beier, Ulrike Stephanie; Dumfahrt, Herbert

doi:10.3109/00016357.2012.741701

Cited by 19 publications

(20 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The formulation derived from this combination, Pro-Argin, has been described as a novel occlusion technology based on the fact that 8% arginine and calcium carbonate are believed to seal exposed dentinal tubules with a plug that contains arginine, calcium carbonate and phosphate thereby providing relief for DH [52]. This claim has been supported by the results of studies which demonstrated relief of DH for variable periods following the use of Pro-Argin mouthwash or paste [52,53]. Although previous systematic reviews have recommended arginine-containing toothpastes for treatment of DH [50,51].…”

Section: Recent Developments In the Treatment Of Dentine Hypersensitisupporting

confidence: 62%

Dentine Hypersensitivity: Review of a Common Oral Health Problem

Pi¹,

Asa²,

Mohammed³

et al. 2017

J Den Craniofac Res

View full text Add to dashboard Cite

Dentine hypersensitivity remains an enigma. Although, it is known to usually present with sharp, short pain caused by one or more external stimuli, it is often inadequately understood. Controversies therefore abound concerning the appropriate terminology for the condition, variations in prevalence, and what is most important to the patients suffering from the condition -a treatment that provides immediate relief with long lasting effect. Available interventions using desensitizing agents provide only temporary relief. The interest of dental practitioners and researchers in dentine hypersensitivity remains very high as it is still a common complaint among patients globally. The myriad array of treatments available and claims of efficacy has not lessened the clinician's dilemma. As a guide and update for clinicians, the aim of this paper is to review the published literature and provide current opinion on the prevalence, aetiology, mechanism, clinical features, treatment as well as the concept of oral health related quality of life among patients with dentine hypersensitivity. A manual and PubMed literature search was conducted using the keywords: dentine hypersensitivity, tooth sensitivity, cervical dentine hypersensitivity, root dentine hypersensitivity in combination with the words prevalence, epidemiology, diagnosis, mechanism, aetiology, clinical features, treatment, oral health or quality of life. The recently developed treatment agents appear promising but will require more randomized clinical trials. Dentine hypersensitivity remains a common condition with significant effect on daily life. The incorporation of a measure of oral health related quality of life is recommended as one of the outcome measures for new treatment modalities.

show abstract

Section: Recent Developments In the Treatment Of Dentine Hypersensitisupporting

confidence: 62%

Dentine Hypersensitivity: Review of a Common Oral Health Problem

Pi¹,

Asa²,

Mohammed³

et al. 2017

J Den Craniofac Res

View full text Add to dashboard Cite

show abstract

“…In a 12-week, randomized, double-blind, splitmouth design clinical trial, the in-office application of arginine-calcium carbonate paste provided significant reduction in sensitivity compared with that of the calcium carbonate control, lasting during the entire follow-up period. 18 In addition, in a randomized double-blind active control clinical trial, in-office treatment with arginine-calcium carbonate paste resulted in a significant reduction in sensitivity compared with sodium fluoride gel, which persisted during the 28 day follow-up period. Using scanning electron microscopy, studies also showed significantly better occlusion of tubules after arginine-calcium carbonate treatment compared with treatment with sodium fluoride gel.…”

Section: Laser and Argmentioning

confidence: 99%

Comparison of Low Level Laser and Arginine-Calcium Carbonate Alone or Combination in the Treatment of Dentin Hypersensitivity: A Randomized Split-Mouth Clinical Study

Bal

Keskiner

Sezer

et al. 2015

Photomedicine and Laser Surgery

View full text Add to dashboard Cite

Objective: This study aimed to compare the efficacy of low-level laser (LLL) and desensitizing paste (DP) containing 8% arginine-calcium carbonate, in the treatment of dentin hypersensitivity (DH) and also to determine whether their combined application would improve the efficacy of the treatment. Background data: There are various options for the treatment of DH; however, superiority of one method over others alone has not been currently demonstrated. Materials and methods: Twenty-one patients with 156 teeth affected by DH were included in the study. Selected teeth were randomly divided into five groups: LLL, DP, laser followed by DP (LLL + DP), DP followed by laser (DP + LLL) applied to one of the quadrants, and a control group, consisting of a randomly selected additional tooth in one of the quadrants. Teeth were irradiated by the 685 nm diode laser treatment with 25 mW at 9 Hz for 100sec at 1 cm 2 area (2J/cm 2 ) in interrupted mode. Pain response to evaporative stimulus was quantified on a visual analogue scale (VAS) over a 90-day period. Results: All four treatment groups experienced significant and persistent decrease in the mean VAS score immediately posttreatment until the end of the study, whereas the placebo group had high VAS scores throughout the study. On day 90, percent reduction in VAS scores was 72% for LLL, 65.4% for DP, 54.6% for LLL + DP, and 69.6% for DP + LLL, whereas the placebo group showed an increase of 7.8%. Conclusions: The application of either LLL or DP containing 8% arginine-calcium carbonate appears to be effective in decreasing DH. However, their combined use does not improve the efficacy beyond what is attainable with either treatment alone.

show abstract

“…The development of a therapy that can provide both immediate relief following professional application and a lasting desensitizing effect for a significant time period after use would be of great assistance to clinicians in dealing with DH. 17,18 The results of the present study demonstrate comparable clinical effectiveness for the two dentifrices with significant reductions in measures of tooth sensitivity, observed across all measures, at all predefined time points, i.e., groups I and II respectively, vs baseline. This is in agreement with the studies by Salian et al, 19 Sharma et al, 20 West et al, 21 and Litkowski and Greenspan.…”

Section: Discussionmentioning

confidence: 55%

Comparative Evaluation of the Effect of Two Desensitizing Dentifrices containing Novamin Technology and Pro-Argin Technology following Scaling and Root Planing

Vazhakkat¹

2017

Journal of Health Sciences &Amp; Research

View full text Add to dashboard Cite

Aim:To compare the desensitizing efficacy of two commercially available dentifrices, one containing Novamin technology (calcium sodium phosphosilicate, a bioactive glass) and the other containing Pro-Argin technology (arginine and calcium carbonate) when applied after scaling and root planing. Materials and methods:About 30 subjects having at least two sensitive teeth (total 60 sites) after scaling and root planing were included in this study and randomly divided into two groups, each containing 15 patients: Group I received Pro-Argin technology (arginine and calcium carbonate) and group II received Novamin technology (calcium sodium phosphosilicate, a bioactive glass) containing desensitizing toothpaste. The sensitive teeth were selected on the basis of Schiff cold air sensitivity scale (SCASS) with an air blast hypersensitivity score of 2 or 3 and cold water test with visual analog scale (VAS) score of 4 to 10 responses. The subjects' response was recorded at baseline (i.e., immediately after treatment) and after 1, 2, and 4 weeks respectively, using the SCASS and VAS scale.Results: Using Mann-Whitney test, we found no statistically significant differences in the score between the two desensitizing toothpastes. But, there was a statistically significant difference between the baseline and follow-up scores done consecutively for individual toothpastes. Conclusion:Therefore, within the limitations of the study, we found no statistically significant difference in the efficacy of the two desensitizing toothpastes.

show abstract

Instant dentin hypersensitivity relief of a single topical application of an in-office desensitizing paste containing 8% arginine and calcium carbonate: A split-mouth, randomized-controlled study

Abstract: The tested in-office desensitizing paste containing 8.0% arginine and calcium carbonate provides significantly greater hypersensitivity relief compared to calcium carbonate alone.

Cited by 19 publications

References 8 publications

Dentine Hypersensitivity: Review of a Common Oral Health Problem

Dentine Hypersensitivity: Review of a Common Oral Health Problem

Comparison of Low Level Laser and Arginine-Calcium Carbonate Alone or Combination in the Treatment of Dentin Hypersensitivity: A Randomized Split-Mouth Clinical Study

Comparative Evaluation of the Effect of Two Desensitizing Dentifrices containing Novamin Technology and Pro-Argin Technology following Scaling and Root Planing

Contact Info

Product

Resources

About