Instantaneous Transfer Entropy for the Study of Cardiovascular and Cardio-Respiratory Nonstationary Dynamics

Valenza, Gaetano; Faes, Luca; Citi, Luca; Orini, Michele; Barbieri, Riccardo

doi:10.1109/tbme.2017.2740259

Cited by 17 publications

(21 citation statements)

References 62 publications

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“…Similar to extended Granger causality, the concept was presented earlier by Faes et al (2013), who introduced so-called compensated transfer entropy, which also includes zero-lags elements into consideration. Instantaneous transfer entropy has also been already used by Valenza et al (2018) for physiological analyses. Nevertheless, we decided not to incorporate the method in the analysis as there is no output value for transfer entropy such as prediction improvement or p -value, that can be easy to interpret for physicians.…”

Section: Discussionmentioning

confidence: 99%

“…Going into greater detail, the next step is temporal causality analysis. Granger-based causality or transfer entropy are the two most important methods (Faes et al, 2013; Porta et al, 2017; Valenza et al, 2018). In general, regardless of the details in various formulations, they may cover different aspects of relations between two time series, except for linear Gaussian processes, when they can be considered equivalent (Porta and Faes, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Cardiorespiratory Temporal Causal Links and the Differences by Sport or Lack Thereof

Młyńczak

Krysztofiak

2019

Front. Physiol.

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Fitness level, fatigue and adaptation are important factors for determining the optimal training schedule and predicting future performance. We think that adding analysis of the mutual relationships between cardiac and respiratory activity enables better athlete profiling and feedback for improving training. Therefore, the main objectives were (1) to apply several methods for temporal causality analysis to cardiorespiratory data; (2) to establish causal links between the signals; and (3) to determine how parameterized connections differed across various subgroups. One hundred elite athletes (31 female) and a control group of 20 healthy students (6 female) took part in the study. All were asked to follow a protocol comprising two 5-min sessions of free breathing - once supine, once standing. The data were collected using Pneumonitor 2. Respiratory-related curves were obtained through impedance pneumography, along with a single-lead ECG. Several signals (e.g., tidal volume, instantaneous respiratory rate, and instantaneous heart rate) were derived and stored as: (1) raw data down-sampled to 25Hz; (2) further down-sampled to 2.5Hz; and (3) beat-by-beat sequences. Granger causality frameworks (pairwise-conditional, spectral or extended), along with Time Series Models with Independent Noise (TiMINo), were studied. The connections enabling the best distinctions were found using recursive feature elimination with a random forest kernel. Temporal causal links are the most evident between tidal volume and instantaneous heart rate signals. Predictions of the “effect” variable were improved by adding preceding “cause” samples, by medians of 20.3% for supine and 14.2% for standing body positions. Parameterized causal link structures and directions distinguish athletes from non-athletes with 83.3% accuracy on average. They may also be used to supplement standard analysis and enable classification into groups exhibiting different static and dynamic components during performance. Physiological markers of training may be extended to include cardiorespiratory data, and causality analysis may improve the resolution of training profiling and the precision of outcome prediction.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cardiorespiratory Temporal Causal Links and the Differences by Sport or Lack Thereof

Młyńczak

Krysztofiak

2019

Front. Physiol.

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“…Indeed, the obtained accuracy, with associated specificity and sensitivity, may increase with a proper optimization of the classification algorithm. Future works will also focus on the investigation of combined scaling and multifractal analysis, and instantaneous nonlinear/complex heartbeat dynamics including time-varying bispectra [14], time-varying Lyapunov spectra [45], and timevarying monovariate and multivariate cardiac entropy [16], [46], extending therefore to higher-order statistics the recently proposed complexity variability framework [45] (which is currently defined through second-order moments).…”

Section: Discussionmentioning

confidence: 99%

Mortality Prediction in Severe Congestive Heart Failure Patients With Multifractal Point-Process Modeling of Heartbeat Dynamics

Valenza

Wendt

Kiyono

et al. 2018

IEEE Trans. Biomed. Eng.

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Multifractal analysis of human heartbeat dynamics has been demonstrated to provide promising markers of Congestive Heart Failure (CHF). Yet, it crucially builds on the interpolation of RR intervals series, which has been generically performed with limited links to CHF pathophysiology. We devise a novel methodology estimating multifractal autonomic dynamics from heartbeat-derived series defined in the continuous time. We hypothesize that markers estimated from our novel framework are also effective for mortality prediction in severe CHF. We merge multifractal analysis within a methodological framework based on inhomogeneous point process models of heartbeat dynamics. Specifically, wavelet coefficients and wavelet leaders are computed over measures extracted from instantaneous statistics of probability density functions characterizing and predicting the time until the next heartbeat event occurs. The proposed approach is tested on data from 94 CHF patients, aiming at predicting survivor and non-survivor individuals as determined after a 4 years follow up. Instantaneous markers of vagal and sympatho-vagal dynamics display power-law scaling for a large range of scales, from s to s. Using standard SVM algorithms, the proposed inhomogeneous point-process representation based multifractal analysis achieved the best CHF mortality prediction accuracy of 79.11 % (sensitivity 90.48%, specificity 67.74%). Our results suggest that heartbeat scaling and multifractal properties in CHF patients are not generated at the sinus-node level, but rather by the intrinsic action of vagal short-term control and of sympatho-vagal fluctuations associated with circadian cardiovascular control, especially within the VLF band. These markers might provide critical information in devising a clinical tool for individualized prediction of survivor and non-survivor CHF patients.

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“…(3) into Eq. (1), all parameters can be estimated by the local maximum likelihood method [42], [60], and the model goodness-of-fit is assessed as in the previous section. The estimated parameters are time-resolved and estimated every 5 ms [42], [60], and the modeling is fully probabilistic with evaluable goodness-of-fit.…”

Section: B Bivariate Point Process Model Of Brain-heart Interplaymentioning

confidence: 99%

Time-Resolved Brain-to-Heart Probabilistic Information Transfer Estimation Using Inhomogeneous Point-Process Models

Catrambone

Talebi

Barbieri

et al. 2021

IEEE Trans. Biomed. Eng.

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The quantification of functional brainheart interplay through the dynamics of the central and autonomic nervous systems may provide effective biomarkers for cognitive, emotional, and autonomic state changes. Despite several computational models were proposed to this end, none provides a directional estimation of such interplay in a time-resolved and probabilistic fashion. Methods: In this study, a multivariate inhomogeneous point-process model for heartbeat dynamics is employed to derive subject-specific, time-resolved, functional estimates of the directional interplay occurring from the brain to the heart, whose activity is represented by electroencephalography and R-peaks intervals series. An inverse-Gaussian probability density function is used to predict heartbeat events as a function of neural dynamics, which is modeled as an exogenous input to the autoregressive cardiac dynamics. Results: The performance is evaluated using heart rate variability and electroencephalography series gathered from 24 healthy volunteers undergoing a coldpressor test, and the modeling goodness-of-fit is assessed through the time-rescaling theorem. The results suggest that cortical dynamics drives heartbeat series with specific time delays in the range of 30 s to 60 s and 90 s to 120 s from the peripheral thermal stress onset. Conclusion: The proposed framework provides novel insights in human neurophysiology, exploiting a fully probabilistic definition of the continuous functional brain-heart interplay.

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Instantaneous Transfer Entropy for the Study of Cardiovascular and Cardio-Respiratory Nonstationary Dynamics

Cited by 17 publications

References 62 publications

Cardiorespiratory Temporal Causal Links and the Differences by Sport or Lack Thereof

Cardiorespiratory Temporal Causal Links and the Differences by Sport or Lack Thereof

Mortality Prediction in Severe Congestive Heart Failure Patients With Multifractal Point-Process Modeling of Heartbeat Dynamics

Time-Resolved Brain-to-Heart Probabilistic Information Transfer Estimation Using Inhomogeneous Point-Process Models

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