Institutional animal care and use committee review of clinical studies

Kendall, Lon V.; Petervary, Nicolette; Bergdall, Valerie; Page, Rod; Baneux, P.

doi:10.2460/javma.253.8.980

Cited by 9 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The authors were given permission to use the data after analysis for diagnostic purposes had taken place. As this testing is a requirement of race participation and a veterinary-client-patient relationship was present at the time of collection, ethical approval from our institution was not required [ 14 , 15 ]. Dogs were rested from exercise for at least 12 hours and fed and watered normally before blood collection.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The effect of age and sex on selected hematologic and serum biochemical analytes in 4,804 elite endurance-trained sled dogs participating in the Iditarod Trail Sled Dog Race pre-race examination program

Connolly

Nelson²,

Jones³

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

Endurance-trained sled dogs provide a unique translational model to characterize changes in hematologic and serum biochemical analytes due to the aging process. The primary objective of this study was to determine the effect of age and sex on specific hematologic and serum biochemical parameters in the endurance trained sled dog. Longitudinal and cross-sectional data were analyzed from 9,746 blood and serum samples from 4,804 dogs collected over 7 years as part of the Iditarod Trail Sled Dog Race pre-race examination program. Mixed models analysis was used for statistical analysis and P < 0.01 was considered significant. Dogs ranged from 1-12 years of age and 39% were female. Serum total calcium and phosphorus concentrations and white blood cell count decreased nonlinearly to asymptotic values by 6.6, 3.1, and 6.9 years of age, respectively, equivalent to estimated physiologic ages in human years of 44, 27, and 46 years. Serum glucose concentrations reached their lowest value at 7.8 years of age, equivalent to an estimated human physiologic age of 50 years, after which time the concentration increased. Serum globulin concentrations increased with age, but nonlinearly for females and linearly for males. Most sex-related differences were <5%; however, females had lower serum urea nitrogen (14.7%) and creatinine (7.3%) concentrations, lower serum alanine aminotransferase activity (16.6%), and higher serum total bilirubin concentration (12.8%) and platelet count (6.0%). The endurance-trained sled dog provides an excellent model to separate the physiologic effects of age from those of a sedentary lifestyle on hematologic and serum biochemical analytes.

show abstract

Section: Methodsmentioning

confidence: 99%

“…required [14,15]. Dogs were rested from exercise for at least 12 hours and fed and watered normally before blood collection.…”

Section: Plos Onementioning

confidence: 99%

The effect of age and sex on selected hematologic and serum biochemical analytes in 4,804 elite endurance-trained sled dogs participating in the Iditarod Trail Sled Dog Race pre-race examination program

Connolly

Nelson²,

Jones³

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…What constitutes the right body for review and approval of veterinary clinical studies is likely institution-dependent based on local expertise and available infrastructure. The American Veterinary Medical Association (AVMA) has previously provided some guidance on the appropriate constitution of review bodies for veterinary clinical research and various groups have weighed in on approaches to quality assurance [4][5][6][7] . Regardless of which body (or bodies) review and approve veterinary clinical research at a given institution, our survey results suggest that review criteria and weighting of individual importance of particular review items, varies substantially between institutions.…”

Section: Discussionmentioning

confidence: 99%

A CTSA One Health Alliance (COHA) survey of clinical trial infrastructure in North American veterinary institutions

et al. 2021

View full text Add to dashboard Cite

While a necessary step toward enhancing rigor and reproducibility of veterinary clinical trials conducted on the translational spectrum includes understanding the current state of the field, no broad assessment of existing veterinary clinical trial resources has been previously conducted. Funded by a CTSA One Health Alliance (COHA) pilot award, the goal of this project was to conduct an electronic survey of North American Veterinary Colleges regarding practices in veterinary clinical trial review, approval, conduct, and support in order to identify opportunities to leverage existing resources and develop new ones to enhance the impact of veterinary and translational health research.A total of 30 institutions were invited to participate in the survey and the survey response rate was 73 %. The most common source of funding noted for veterinary clinical research was industry (33 %); however, respondents reported that only 5 % (3.7–11.0) of studies were FDA-regulated. Respondents indicated that most studies (80 %); conducted at their institution were single site studies. Study review and approval involved the IACUC either solely, or in combination with a hospital review board, at 95.5 % of institutions. Workforce training related to clinical research best practices was variable across institutions. Opportunities were identified to strengthen infrastructure through harmonization of clinical research review and approval practices. This might naturally lead to expansion of multi-site studies. Based on respondent feedback, future workforce development initiatives might center on training in the specifics of conducting FDA-sponsored research, Good Clinical Practice (GCP), clinical study budget design, grants management, adverse event reporting, study monitoring and use of electronic data capture platforms.

show abstract

“…As there are no clear international guidelines, rules often vary in different countries [ 41 ]. However, it is often for the institution involved in the companion animal trial to set the rules when clear guidelines are not available [ 42 ]. Clear and detailed owner consent forms and ethical approval from the institution involved in the study are usually the main requirements to perform a companion animal clinical trial in most countries [ 42 , 43 ].…”

Section: Spontaneously Occurring Cancers In Companion Animals Represent a Unique Model For Human Cancersmentioning

confidence: 99%

Companion Animal Model in Translational Oncology; Feline Oral Squamous Cell Carcinoma and Canine Oral Melanoma

Giuliano

2021

Biology

View full text Add to dashboard Cite

Companion animals with naturally occurring cancers can provide an advantageous model for cancer research and in particular anticancer drug development. Compared to commonly utilized mouse models, companion animals, specifically dogs and cats, share a closer phylogenetical distance, body size, and genome organization. Most importantly, pets develop spontaneous, rather than artificially induced, cancers. The incidence of cancer in people and companion animals is quite similar and cancer is the leading cause of death in dogs over 10 years of age. Many cancer types in dogs and cats have similar pathological, molecular, and clinical features to their human counterparts. Drug toxicity and response to anti-cancer treatment in dogs and cats are also similar to those in people. Companion animals share their lives with their owners, including the environmental and socioeconomic cancer-risk factors. In contrast to humans, pets have a shorter life span and cancer progression is often more rapid. Clinical trials in companion animals are cheaper and less time consuming compared to human trials. Dogs and cats with naturally occurring cancers are an ideal and unique model for human cancer research. Model selection for the specific type of cancer is of pivotal importance. Although companion animal models for translational research have been reviewed previously, this review will try to summarize the most important advantages and disadvantages of this model. Feline oral squamous cell carcinoma as a model for head and neck squamous cell carcinoma and canine oral melanoma as a model for mucosal melanoma and immunotherapy in people will be discussed as examples.

show abstract

Institutional animal care and use committee review of clinical studies

Cited by 9 publications

References 9 publications

The effect of age and sex on selected hematologic and serum biochemical analytes in 4,804 elite endurance-trained sled dogs participating in the Iditarod Trail Sled Dog Race pre-race examination program

The effect of age and sex on selected hematologic and serum biochemical analytes in 4,804 elite endurance-trained sled dogs participating in the Iditarod Trail Sled Dog Race pre-race examination program

A CTSA One Health Alliance (COHA) survey of clinical trial infrastructure in North American veterinary institutions

Companion Animal Model in Translational Oncology; Feline Oral Squamous Cell Carcinoma and Canine Oral Melanoma

Contact Info

Product

Resources

About