The optimization of the processing conditions in the production of soy protein bioplastics by injection molding has been essential in order to develop materials with a great capacity to absorb water while displaying good mechanical properties. Using a 50/50 (wt/wt) soy protein/glycerol mixture, and 40 °C, 500 bar, and 70 °C as reference values for cylinder temperature, injection pressure, and mold temperature, respectively, the effect of those processing parameters over thermomechanical and hydrophilic properties was studied. Processing parameters did not show a great influence over the thermomechanical bending properties within temperatures ranging from −30 to 130 °C, as most samples displayed a similar response, independently of the parameter studied. On the other hand, when studying tensile and hydrophilic properties, the main effect corresponded to the cylinder and mold temperature values, as pressure did not exert a clear influence when increased from 300 to 900 bar. Samples with a lower water uptake were obtained when processed at higher temperature, as a result of crosslinking promotion. Moreover, a greater extensibility was observed when bioplastics are processed at high mold temperatures. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43524.