Institutionalizing technoscience: Post-genomic technologies and the case of systems biology

DIY Laboratories and business innovation ecosystems: The case of pharmaceutical industry

“…However, the biological revolution led to a fundamental technological discontinuity (Sabatier et al, 2012;De Alcantara and Martens, 2019), in that the discovery and the development of new biochemical drugs require a completely different set of bioscientific technology competences (Bonaccorsi and Vargas, 2010;Sabatier et al, 2012). Therefore, the existing dominant R&D logic of pharmaceutical firms following a single technology development pathway becomes insufficient (Sabatier et al, 2012;Tierney et al, 2013), because the latest advancement of biopharma innovations is often generated at the interface between multiple root biopharma research areas (Allhoff, 2009;Styhre, 2011). In this sense, innovations led by practitioners in DIY laboratories may push forward the frontier of biopharma research from a new angle (Fox, 2014, Seyfried et al, 2014Hecker et al, 2018).…”

“…At the other end, pharmaceutical firms are more interested in projects with high commercial potentials (Lauto and Valentin, 2016;De Beer and Jain, 2018). However, this narrow commercial focus may ignore new findings in relevant biopharma fields (Allhoff, 2009;Styhre, 2011). By linking these two entities and align their interests, CROs arguably can act as an important hub in this innovation ecosystem to transform the inclusive biopharma innovations originated from DIY laboratories into real economic returns and societal benefits.…”

The pharmaceutical technology landscape: A new form of technology roadmapping

“…First and second generation roadmaps are focused on a single root technology based innovation or product. A shift has occurred and many of today's pharmaceutical innovations are increasingly generated at the interface of two or more root technologies [106,6]. Innovations developed at the interface of multiple root technologies are perhaps the single most problematic issue for current roadmapping techniques to address.…”