The two-worlds framework is currently the most important account of morality policymaking in Europe. For this theory of elite behaviour to be valid, a number of implicit assumptions about political belief systems at the mass level must hold. This contribution spells out these assumptions and tests them within a structural equation modelling framework, using original survey data from Germany, a country that constitutes a crucial case for the two-worlds theory. The results showed that the implicit individual-level preconditions of the two-worlds framework were fulfilled. Political secularism and partisanship were strongly associated. Political secularism also had strong effects on morality policy preferences regarding the preferred regulation of abortion, embryo and stem cell research, and gene therapies, even when controlling for a host of background variables. However, the size of the effects did not vary across politicised and non-politicised issues. This casts some doubt over the ability of partisan actors to unilaterally control the morality policy agenda.