The article shows that the concepts of harmonious and evolutionary management have significant heuristic potential in the development of institutional engineering, design and management of complex self-organizing systems, as well as contribute to sustainable economic development. The purpose of the article is to identify the mechanisms of conservatism and liberalism synthesis through the tools of harmonious and evolutionary management for productive sustainable economic development. Methodology: An interdisciplinary and systemic methodology is used, the logical and semiotic nature of economic genes and the genotype of the economic system determining characteristics, its orientation and content of the stability of its development are revealed. Results and novelty: basic genotypic concepts and their frames are identified, which determine the motives of economic growth and strategic directed development, mechanisms for implementing the synthesis of economic conservatism and liberalism, the principles of superposition, complementarity, interaction of individual and collective, parts and the whole, management of the economic genotype of the system with its structure − genotypic concepts forming the processes of harmonization, and its sustainable development.