Abstract. The Russian economy in recent years has faced the influence of a number of negative factors due to macroeconomic instability and increased foreign policy tensions. In these conditions the considerable constraints faced processes of socio-economic development of regions of the Russian Federation. In this article the authors attempt to analyze the key indicators of socio-economic development of the regions in which it was created and operate in the territories of priority socio-economic development. These territories are concentrated in the Far Eastern Federal District. The article identified, processed, and interpreted indicators, allowing to produce a conclusion on the interim effectiveness of the territories of priority socio-economic development in Russia in conditions of macroeconomic instability.