Insufficient evidence for association of NOD2/CARD15 or other inflammatory bowel disease–associated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantation

Distinct NOD2 polymorphism status is associated with differential outcome in hematopoietic stem cell transplantation: results from a meta-analysis

“…Although NOD2 polymorphisms were associated with other adverse outcomes (TRM, OS, DFS, or relapse), the finding was not associated specifically with the recipient or the donor. It is possible that we failed to observe such an association because of the heterogeneity in the patient population and clinical circumstances, especially with regard to T-cell depletion [6,7,9] . The implementation and method of T-cell depletion was not uniformly applied in all studies, and such inconsistencies in protocols and their application might have played a confounding role in the meta-analysis.…”

“…Although SNPs 8,12, and 13 are thought to reduce the ability of MDP to activate NOD2 and consequently the activation of NF-κB, resulting in reduction in the production of cytokines and antimicrobial peptides, these loss-of-function effects caused by the SNPs initially proved controversial, as an enhanced cytokine response is characteristic of GvHD. Naturally, other studies have yielded inconsistent results [8,9] , possibly due to limited sample size, differences in genetic background within a transplant pair, and variable study designs [3,10,11] . Here, a comprehensive search and meta-analysis were used for the first time to confirm the association of differential NOD2 polymorphism status in Caucasian ethnic populations with HSCT outcome.…”

Translational opportunities for targeting the Th17 axis in acute graft-vs.-host disease

“…Three studies evaluated the relation between the presence of the single-nucleotide polymorphism (SNP) rs11209026 (1142G>A) in IL-23R and aGVHD [85][86][87] . In two studies, 85,86 there was a significant reduction of aGVHD incidence in patients who where transplanted from a donor with the IL-23R SNP, while there was no effect when it was in the recipient, and the third study fail to identify any effect of the polymorphism 87 .…”

“…Three studies evaluated the relation between the presence of the single-nucleotide polymorphism (SNP) rs11209026 (1142G>A) in IL-23R and aGVHD [85][86][87] . In two studies, 85,86 there was a significant reduction of aGVHD incidence in patients who where transplanted from a donor with the IL-23R SNP, while there was no effect when it was in the recipient, and the third study fail to identify any effect of the polymorphism 87 . In healthy donors, the presence of the IL-23r SNP promotes the expression of soluble IL-23R 88 and, consequently, diminished IL-23 signaling, leading to a decreased IL-23-dependent IL-17 and IL-22 production and STAT3 phosphorylation 89,90 .…”

NOD2/CARD15 gene polymorphisms affect outcome in pediatric allogeneic stem cell transplantation

“…1 Subsequently some groups confirmed unfavorable association, 2-5 whereas others did not. [6][7][8][9][10] Because the impact of NOD2/CARD15 on SCT is still debatable, we initiated a retrospective multicenter study in pediatric patients (median age 9.8 years [0.2-21 years]) who received allo-SCT. The study was approved by the GoetheUniversity ethics committee (no.…”