Insufficient Glucuronide Formation in the Newborn and its Relationship to the Pathogenesis of Icterus Neonatorum

Vest, M

doi:10.1136/adc.33.171.473

Cited by 57 publications

(21 citation statements)

References 17 publications

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“…The present study was, therefore, undertaken to evaluate the effect of maternally administered dexamethasone on the serum bilirubin levels of premature infants. Since the hepatic microsomal enzyme glucuronyl transferase (UDPGT), which is immature in the newborn infant [1, 8,24], plays a key role in the metabolism of both bilirubin and glucocorticoids [7], it was also of some interest to provide additional data by studying the influence of prenatal dexamethasone treatment on the urinary D-glucaric acid excretion of infants bom prematurely.…”

Section: Introductionmentioning

confidence: 99%

Hyperbilirubinemia and urinary D-glucaric acid excretion in premature infants following antepartum dexamethasone treatment

Németh¹,

T²,

Boda³

1981

Journal of Perinatal Medicine

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Section: Introductionmentioning

confidence: 99%

Hyperbilirubinemia and urinary D-glucaric acid excretion in premature infants following antepartum dexamethasone treatment

Németh¹,

T²,

Boda³

1981

Journal of Perinatal Medicine

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“…On the first day, an average of 35% of the administered bili rubin was retained in the circulation in 3-h specimens, whereas on the 5th day of life, bilirubinemia dropped within I h to the initial level and sometimes even below it. Thus, the ability to remove unconjugated bilirubin from the serum increases within the first week of life, which corresponds with the in creasing capacity of the liver to form glucuronides [Vest, 1958]. In older children (8 months to 15 years) [W eech and Van d .…”

Section: Discussionmentioning

confidence: 99%

Bilirubin Clearance in Healthy and Pathological Newborns

Heringová¹,

Jirsová²,

K³

1972

Neonatology

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“…Jaundice in the normal newborn infant has been attributed to the inability of the liver to conjugate bilirubin due to decreased activity of the glucuronyltransferase enzyme (46)(47)(48) in the face of a relatively "normal" rate of bilirubin production. However, our results indicate that normal newborns produce bilirubin at more than twice the adult rate (per kilogram per 24 hr).…”

Section: Co Production and Mean Red Cell Life Span (Mls)mentioning

confidence: 99%

Endogenous production of carbon monoxide in normal and erythroblastotic newborn infants

Maisels¹,

Pathak²,

Nelson³

et al. 1971

J. Clin. Invest.

131

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A B S T R A C T The endogenous production of carbon monoxide (Vco) in newborn infants was measured by serial determinations of blood carboxyhemoglobin during rebreathing in a closed system. Mean Vco in nine full-term infants was 13.7 zt3.6 Al CO/kg per hr (SD), and in four erythroblastotic infants Vco ranged from 37 to 154 sl CO/kg per hr preceding exchange transfusion. Mean red cell life-span (MLS) and total bilirubin production were calculated from Yco. MLS in normal newborns was 88 :1:15 days (SD), and bilirubin production was 8.5 =12.3 mg/kg per 24 hr. This is more than twice the amount of bilirubin normally produced in the adult per kilogram of body weight. Normal infants achieved a net excretion of bilirubin of at least 5.6 4-2.3 mg/kg per 24 hr (SD) as calculated from the bilirubin production and the measured rise in serum bilirubin concentration.The measurement of Vco should prove valuable in the study of red blood cell survival and bilirubin metabolism in the newborn infant. INTRODUCTIONThe recent studies of Coburn and coworkers (1-3) have confirmed the original observations by Sjbstrand (4-6) that carbon monoxide (CO) is endogenously produced in normal man, and that approximately 1 mole of CO is produced per mole of heme catabolized (2).

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Insufficient Glucuronide Formation in the Newborn and its Relationship to the Pathogenesis of Icterus Neonatorum

Cited by 57 publications

References 17 publications

Hyperbilirubinemia and urinary D-glucaric acid excretion in premature infants following antepartum dexamethasone treatment

Hyperbilirubinemia and urinary D-glucaric acid excretion in premature infants following antepartum dexamethasone treatment

Bilirubin Clearance in Healthy and Pathological Newborns

Endogenous production of carbon monoxide in normal and erythroblastotic newborn infants

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