2021
DOI: 10.1111/bjh.17294
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Insufficient thrombopoietin due to hepatic dysmature results in thrombocytopenia in small‐for‐gestational‐age rats

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Cited by 2 publications
(4 citation statements)
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“…We previously demonstrated that a decrease in TPO production due to hepatic dysmaturation resulted in thrombocytopenia in SGA model rats. 9 In the present study, SGA infants with thrombocytopenia had lower IPF and serum TPO levels than non-SGA infants with thrombocytopenia. These results suggest that IPF and TPO levels do not increase in response to thrombocytopenia in human SGA infants, similar to SGA model rats.…”
Section: Discussionsupporting
confidence: 47%
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“…We previously demonstrated that a decrease in TPO production due to hepatic dysmaturation resulted in thrombocytopenia in SGA model rats. 9 In the present study, SGA infants with thrombocytopenia had lower IPF and serum TPO levels than non-SGA infants with thrombocytopenia. These results suggest that IPF and TPO levels do not increase in response to thrombocytopenia in human SGA infants, similar to SGA model rats.…”
Section: Discussionsupporting
confidence: 47%
“…These results demonstrate that all SGA infants showed asymmetrical growth due to maternal/placental factors. 9 , 12 These SGA infants are at increased risk for complications, such as prematurity, asphyxia, hypothermia, hypoglycemia, hypocalcemia, polycythemia, and thrombocytopenia. 1 , 2 Chronic intrauterine hypoxia caused by maternal factors for SGA infants leads to high fetal erythropoietin and polycythemia.…”
Section: Discussionmentioning
confidence: 99%
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