2019
DOI: 10.1111/joim.12887
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Insulin action is severely impaired in adipocytes of apparently healthy overweight and obese subjects

Abstract: Ryd en M, Petrus P, Andersson DP, Medina-G omez G, Escasany E, Corrales Cord on P, Dahlman I, Kulyt e A, Arner P (Karolinska ). Insulin action is severely impaired in adipocytes of apparently healthy overweight and obese subjects. J Intern Med 2019; 285: 578-588.Objective. Many overweight/obese subjects appear metabolically healthy with normal in vivo insulin sensitivity. Still, they have increased long-term risk of developing type 2 diabetes. We hypothesized that adipose tissue dysfunction involving decreased… Show more

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Cited by 21 publications
(17 citation statements)
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“…The increased inflammation of adipose tissue in FKO mice may also lead to insulin resistance in a high-fat diet. A recent study 72 showed that, compared to the adipocytes of lean individuals, anti-lipolysis and adipogenesis activities sensitive to insulin in adipocytes from individuals who are overweight or obese significantly receded. In particular, anti- Figure 2 Anti-lipolysis regulation by insulin on the morphological differences of adipose tissue.…”
Section: Anti-lipolysis Induced By Insulin In Adipose Hypertrophymentioning
confidence: 99%
“…The increased inflammation of adipose tissue in FKO mice may also lead to insulin resistance in a high-fat diet. A recent study 72 showed that, compared to the adipocytes of lean individuals, anti-lipolysis and adipogenesis activities sensitive to insulin in adipocytes from individuals who are overweight or obese significantly receded. In particular, anti- Figure 2 Anti-lipolysis regulation by insulin on the morphological differences of adipose tissue.…”
Section: Anti-lipolysis Induced By Insulin In Adipose Hypertrophymentioning
confidence: 99%
“…In relation to the focal adhesion GO term, one interesting study reported that adipocytes from overweight/obese people display decreased insulin sensitivity and reduced expression of AKT2, which it is associated with higher methylation at regulatory sites in the AKT2 promoter. These findings indicate that healthy and non-diabetic subjects have already disturbed insulin signaling in the overweight state; it is worsened in healthy obese individuals and being only slightly aggravated in metabolically unhealthy obesity, consequently contributing to early defects in insulin action in adipocytes [133].…”
Section: Cell Adhesionmentioning
confidence: 81%
“…Most definitions of MHO are based on the criteria for metabolic syndrome based on the definition provided by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP-III)[ 9 ], which include: (1) The presence of central obesity, waist circumference ≥ 102 cm ( 90 cm for Asians) in men and ≥ 88 cm ( 80 cm for Asians) in women; (2) Systolic blood pressure ≥ 17.3 kPa (130 mmHg) and/or diastolic blood pressure ≥ 11.3 kPa (85 mmHg); (3) Triglycerides ≥ 1.7 mmol/L (150 mg/dL); (4) Fasting blood glucose ≥ 5.6 mmol/L (100 mg/dL); and (5) High-density lipoprotein cholesterol (HDL-C) less than 1.03 mmol/L (40 mg/dL) in men or less than 1.30 mmol/L (50 mg/dL) in women. Most definitions of MHO require fewer than two or the absence of any metabolic abnormalities except for waist circumference[ 7 , 10 - 13 ]. However, the details of the MHO definitions are slightly different.…”
Section: Prevalence Of Metabolically Healthy Obesitymentioning
confidence: 99%
“…The action of insulin on subcutaneous adipocytes is impaired as well. Rydén et al [ 10 ] compared the inhibitory action on lipolysis and the stimulatory effect on lipogenesis of insulin in metabolically healthy subjects who were lean, overweight, or obese and found that insulin resistance was already observed in metabolically healthy overweight and obese subjects. In the classical agonist-receptor interaction model, the half-maximum effects for insulin to inhibit adipocyte lipolysis and lipogenesis in overweight/obese people were 10 times and 100 times higher than that in lean people, respectively.…”
Section: Possible Mechanisms Of the Future Incidence Of T2dm In Mhomentioning
confidence: 99%