1999
DOI: 10.1051/rnd:19990104
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Insulin action on skeletal muscle protein metabolism during catabolic states

Abstract: -Insulin plays a major role in the regulation of skeletal muscle protein turnover but its mechanism of action is not fully understood, especially in vivo during catabolic states. These aspects are presently reviewed. Insulin inhibits the ATP-ubiquitin proteasome proteolytic pathway which is presumably the predominant pathway involved in the breakdown of muscle protein. Evidence

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Cited by 28 publications
(16 citation statements)
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“…Conversely, IGF-I decreased basal levels of protein breakdown, increased total RNA, and, most notably, prevented the Dex-induced increase in overall and myofibrillar protein breakdown and the decrease in protein content. Thus IGF-I is a dominant signal over glucocorticoids in determination of muscle protein balance in vitro, as has been suggested for insulin in vivo (17). Simultaneous administration of IGF-I with glucocorticoids to rats significantly attenuates the glucocorticoid-induced muscle atrophy and myofibrillar protein breakdown as measured by 3-MH excretion (21).…”
Section: Discussionmentioning
confidence: 76%
“…Conversely, IGF-I decreased basal levels of protein breakdown, increased total RNA, and, most notably, prevented the Dex-induced increase in overall and myofibrillar protein breakdown and the decrease in protein content. Thus IGF-I is a dominant signal over glucocorticoids in determination of muscle protein balance in vitro, as has been suggested for insulin in vivo (17). Simultaneous administration of IGF-I with glucocorticoids to rats significantly attenuates the glucocorticoid-induced muscle atrophy and myofibrillar protein breakdown as measured by 3-MH excretion (21).…”
Section: Discussionmentioning
confidence: 76%
“…In addition, various metabolic disturbances liable to be accompanied by acidosis (diabetes, sepsis) result in a decrease in insulin action on protein synthesis or degradation but, in contrast, the antiproteolytic action of insulin could be improved during hyperthyroidism (Grizard et al 1999).…”
Section: Acid-base Status and Protein Metabolismmentioning
confidence: 99%
“…In healthy adult humans, insulin promotes an anabolic state, augmenting cellular glucose uptake and enhancing muscle protein deposition (23,30,41). During experimental sepsis, LPS has been shown to induce pancreatic insulin secretion (28) and to increase circulating insulin levels similar to that observed in naturally occurring sepsis (32,46).…”
mentioning
confidence: 96%