Insulin Activity of Normal Plasma and Plasma Acid-Ethanol Extracts

Insulin Antagonistic Effect of Human Plasma Albumin on Protein Synthesis in vitro and on Glycogen Synthesis in vivo in the Rat Diaphragm Muscle

“…With few exceptions (Keen 1963, Cameron, Keen andMenzinger 1964) there now seems to be general agreement that human plasma albumin will reduce the effect of insulin on the glucose uptake of the cut rat hemidiaphragm in vitro (Vallance-Owen et al 1958, Lowy et al 1961, Jervell 1963, Alp and Recant 1964. The effect is relatively independent of the method used for the isolation of the albumin, and also of the albumin's content of free fatty acids and its calcium and magnesium binding property.…”