Insulin and glucose levels during CPR in the canine model

Martin, Gérard B.; O’Brien, John F.; Best, Randall; Goldman, Jack A.; Tomlanovich, Michael C.; Nowak, Richard M.

doi:10.1016/s0196-0644(85)80089-5

Cited by 10 publications

(1 citation statement)

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“…Less is known about implications of ultraacute hyperglycemia during the first hours after cardiac arrest. In animals, ventricular fibrillation with subsequent resuscitation suppresses insulin secretion and causes a more than threefold rise in blood glucose (7), peaking immediately after ROSC and declining to baseline within 2–3 h (8,9). However, in humans hyperglycemia is still commonly observed at the time of intensive care unit admission (2).…”

Section: Discussionmentioning

confidence: 99%

Early Increase in Blood Glucose in Patients Resuscitated From Out-of-Hospital Ventricular Fibrillation Predicts Poor Outcome

et al. 2012

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OBJECTIVETo describe the trend of blood glucose immediately after successful resuscitation from out-of-hospital ventricular fibrillation.RESEARCH DESIGN AND METHODSData from cardiac arrest registry supplemented with blood glucose data were analyzed in this population-based observational study. Between 2005 and 2009, a total of 170 adult patients survived to hospital admission after resuscitation from bystander-witnessed cardiac arrest of cardiac origin and ventricular fibrillation as an initial rhythm.RESULTSSufficient data for analysis were available in 134 (79%) patients, of whom 87 (65% [95% CI 57–73]) survived to hospital discharge in Cerebral Performance Category 1 or 2. Blood glucose did not change significantly between prehospital (10.5 ± 4.1 mmol/L) and admission (10.0 ± 3.7 mmol/L) in survivors (P = 0.3483), whereas in nonsurvivors, blood glucose increased from 11.8 ± 4.6 to 13.8 ± 3.3 mmol/L (P = 0.0025).CONCLUSIONS Patients who are resuscitated from out-of-hospital ventricular fibrillation, but whose outcome is unfavorable are characterized by significant increase of blood glucose in the ultraacute postresuscitation phase.

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