Insulin and IGF-1 in goat milk: influence of the diet

Magistrelli, D.; Valli, Alice; Rosi, F.

doi:10.4081/ijas.2005.2s.386

Cited by 13 publications

(11 citation statements)

References 11 publications

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“…Dietary treatment did not significantly affect plasma INS levels, although they have been previously correlated with energy intake in adult goats (Magistrelli et al, 2005;Todini et al, 2007b). The correlation between INS levels and the adiposity state, previously reported in sheep (Archer et al, Dietary supplement, mohair and hormones in Angora kids 2002) was confirmed in the present study, where plasma INS was positively correlated with LW and BCS.…”

Section: Discussionsupporting

confidence: 86%

“…Circulating levels of total IGF-1 were not different between the two groups, while a positive correlation with the level of nutrition was previously reported in sheep (Bass et al, 1991;Adams et al, 2000;Pittroff et al, 2006) and goats (Magistrelli et al, 2005). It is noteworthy that dietary supplementations, with soybean, failed to induce a rise in plasma INS and IGF-1 in Merino rams, an effect which was observed with cowpea and lupin (Blache et al, 1996).…”

Section: Discussionsupporting

confidence: 53%

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Effects of field bean (Vicia faba L. var. minor) dietary supplementation on plasma thyroid hormones, insulin, insulin‐like growth factor‐1 concentrations and mohair characteristics in growing Angora goat kids

Acuti¹,

Todini²,

Malfatti³

et al. 2009

Animal Physiology Nutrition

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Twenty-two Angora kids were used to study the effect of a dietary supplementation with field bean (Vicia faba L. var. minor) on hair follicle activity, mohair characteristics and plasma total thyroxine (T4), triiodothyronine (T3), insulin (INS) and insulin-like growth factor-1 (IGF-1) concentrations. At birth, their mothers were divided in two groups (S: supplemented, C: control), the S group being supplemented with 300 g/head/day of whole field bean. At weaning, diet of kids from S group was supplemented with 80 g/head/day of whole field bean. At weaning, secondary hair follicle activity (S: 0.91 ± 0.01, C: 0.84 ± 0.02, p < 0.01) and staple length (S: 5.82 ± 0.13 cm, C: 5.16 ± 0.14 cm, p < 0.001) were greater in the S group. At 155 days of age, secondary fibre diameter (S: 16.54 ± 0.35 μm, C: 18.09 ± 0.31 μm, p < 0.01) was higher in the C kids. Concentrations of total plasma T4 and T3 were higher (p < 0.001) in S (120 ± 12 and 4.87 ± 0.92 ng/ml respectively) than in C kids (92 ± 8 and 2.97 ± 0.77 ng/ml respectively). At weaning, T4 values were negatively correlated (p < 0.05) with the secondary fibre diameter and the T3/T4 ratio was positively correlated (p < 0.05) with the secondary to primary hair follicle ratio. At 155 days of age, both T3 and T3/T4 values were positively correlated (p < 0.01) with staple length. Plasma INS (0.11 ± 0.03 ng/ml) and total IGF-1 concentrations (232 ± 13 ng/ml) were not affected by diet. Improvements of diet quality in kids positively affected fibre diameter and length and follicle activity rate. We suggest that increased circulating thyroid hormones concentrations, but not those of INS and IGF-1, may contribute to the beneficial actions of nutritional supplementation on anatomical growth and mohair production of kids.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 53%

Effects of field bean (Vicia faba L. var. minor) dietary supplementation on plasma thyroid hormones, insulin, insulin‐like growth factor‐1 concentrations and mohair characteristics in growing Angora goat kids

Acuti¹,

Todini²,

Malfatti³

et al. 2009

Animal Physiology Nutrition

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“…In this study, the IGF-1 level (between 42.13 and 91.08 ng/mL) measured in the pasture group with higher milk yield compared to the pen group (pasture group 283.73 kg, pen group 184.37 kg; P < 0.001) was higher than the milk IGF-1 level in the pen group (between 30.78 and 52.42 ng/mL). The finding that milk IGF-1 level changed based on feeding systems is consistent with the findings of Magistrelli et al (38). In addition, the blood IGF-1 level (41.7 ng/mL) identified in Saanen goats (35) was found to be similar to the milk IGF-1 level (between 30.78 and 52.42 ng/mL) of the pen group, and it was similar to or higher than that of the pasture group (between 42.13 and 91.08 ng/mL).…”

Section: Igf-1supporting

confidence: 91%

“…In this process, IGF-1 plays an important role in almost all tissue and organ cell proliferation with its metabolic impact on growth and development pathways (36). While it was reported that IGF-1 had no relationship in pigs with lactation milk yield (37), the studies on goats identified relationships between both blood and milk plasma IGF-1 levels and milk yield (35,38). In this study, the IGF-1 level (between 42.13 and 91.08 ng/mL) measured in the pasture group with higher milk yield compared to the pen group (pasture group 283.73 kg, pen group 184.37 kg; P < 0.001) was higher than the milk IGF-1 level in the pen group (between 30.78 and 52.42 ng/mL).…”

Section: Igf-1mentioning

confidence: 99%

Gene expression levels in some candidate genes for mastitis resistance, milk yield,and milk quality of goats reared under different feeding systems

Yakan¹,

Özkan²,

Şakar³

et al. 2018

Turk J Vet Anim Sci

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This study aimed to identify the expression levels of some candidate genes for mastitis resistance (LTF and BRCA1), milk yield (POU1F1 and IGF-1), and milk quality (PPARγ and CSN2) in different feeding systems (pen-and pasture-based) used for Damascus goats. Milk samples were taken from all goats in both pen and pasture groups at 4 times, at the 1st, 3rd, 5th, and 7th months of the study. It was found that, compared to the pen group, the LTF and CSN2 genes in the pasture group had significant levels of upregulation in the 7th month of lactation (3.538-and 5.436-fold, respectively), the PPARγ gene had downregulation at the beginning of lactation (0.399-fold), and the IGF-1 gene had upregulation in the 3rd month of lactation (2.313-fold) but had significant levels of downregulation (2.332-fold) in the 5th month of lactation. It was determined that LTF gene expression levels in goats might be used as a criterion in identifying mastitis resistance, IGF-1 for lactation milk yield, and PPARγ for milk fat yield. This study is the first report that presents LTF, BRCA1, IGF-1, and PPARγ gene expression levels in goat milk and udder epithelial cells and the effect of BRCA1, POU1F1, and PPARγ genes on milk protein yield.

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“…The lack of difference in insulin concentration between the two diets in both species is in contrast to previous studies, where high-starch diets increased insulin concentration, compared to low-starch diets in Saanen goats [ 30 ] and in Sarda ewes [ 5 ]. The higher insulin concentration observed in sheep than goats suggests that the former had a metabolic status more inclined toward an anabolic pathway than the latter and confirmed the inverse relationship between insulin and milk production level [ 31 ].…”

Section: Discussioncontrasting

confidence: 97%

Dietary Starch Concentration Affects Dairy Sheep and Goat Performances Differently during Mid-Lactation

Lunesu

Decandia

Molle

et al. 2021

Animals

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Evolution of milk production, body reserves and blood metabolites and their relationships with dietary carbohydrates were compared in 30 Sarda dairy ewes and 26 Saanen dairy goats in mid-lactation. From 92 to 152 ± 11 days in milk (DIM), each species was allocated to two dietary treatments: high-starch (HS: 20.0% starch, on DM basis) and low-starch (LS: 7.8% starch, on DM basis) diets. In mid-lactating goats, the HS diet increased fat-corrected milk yield (FCM (3.5%); 2.65 vs. 2.53 kg/d; p = 0.019) and daily milk net energy (NEL; p = 0.025), compared to the LS diet. The body condition score (BCS) was not affected. In mid-lactating ewes, the LS diet increased FCM (6.5%) (1.47 vs. 1.36 kg/d; p = 0.008), and NEL (p = 0.008), compared to the HS diet. In addition, BCS was greater in HS than in LS ewes (3.53 vs. 3.38; p = 0.008). Goats had a higher growth hormone (GH) and lower insulin concentration than ewes (GH: 2.62 vs. 1.37 ng/mL; p = 0.04; insulin: 0.14 vs. 0.38 µg/L; p < 0.001 in goats and ewes, respectively). In conclusion, in mid-lactation, the two species responded differently to dietary carbohydrates, probably due to differences in the concentration of GH and insulin. The HS diet favored milk yield in goats and body reserve accumulation in ewes. In ewes, the partial replacement of starch with highly digestible fiber increased energy partitioning in favor of milk production.

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Insulin and IGF-1 in goat milk: influence of the diet

Cited by 13 publications

References 11 publications

Effects of field bean (Vicia faba L. var. minor) dietary supplementation on plasma thyroid hormones, insulin, insulin‐like growth factor‐1 concentrations and mohair characteristics in growing Angora goat kids

Effects of field bean (Vicia faba L. var. minor) dietary supplementation on plasma thyroid hormones, insulin, insulin‐like growth factor‐1 concentrations and mohair characteristics in growing Angora goat kids

Gene expression levels in some candidate genes for mastitis resistance, milk yield,and milk quality of goats reared under different feeding systems

Dietary Starch Concentration Affects Dairy Sheep and Goat Performances Differently during Mid-Lactation

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