Insulin as a potential factor influencing blood pressure in amputees.

Rose, Herbert G.; Yalow, Rosalyn S.; Schweitzer, Paul; Schwartz, Ernest

doi:10.1161/01.hyp.8.9.793

Cited by 47 publications

(14 citation statements)

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“…Systolic and diastolic blood pressures were adjusted for age and sex by use of the standard deviation score (Z)_ calculated according to the formula: Z = (X-X)/SD, where X = measured blood pressure; X = mean of the expected blood pressure for age and sex (data from second National Health and Nutrition Examination Survey [NHANES II]), 8 and SD = standard deviation of the expected blood pressure for age and sex. Linear regression analyses were performed before the weight loss programs using Z score systolic and diastolic blood pressures as the dependent variables, with fasting insulin, fasting glucose, sum of the insulins during an oral glucose tolerance test, 24-hour urinary sodium excretion, body weight, and percentage of fat as independent variables.…”

Section: Discussionmentioning

confidence: 99%

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Insulin and blood pressure during weight loss in obese adolescents.

Rocchini¹,

et al. 1987

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SUMMARY The role of insulin in the regulation of blood pressure was evaluated in 50 obese adolescents before and after a 20-week weight loss program. When compared with 10 nonobese adolescents, the obese subjects had significantly higher systolic, diastolic, and mean arterial pressures (p = 0.005), an elevated 24-hour urinary sodium excretion (p = 0.002), an elevated fasting insulin concentration (p = 0.001), and an abnormal insulin response to an oral glucose tolerance test (sum of the insulins at 0, 1, and 2 hours post-oral glucose load; p = 0.001). We also observed a significant correlation between systolic and diastolic blood pressure (age and sex normalized) and body weight (r= 0.57, p<0.01 and r = 0.7, p<0.01), fasting insulin ( r = 0.49, p<0.01 and r = 0.54, p<0.01), and sum of insulins (r = 0.42, p<0.01 and r = 0.46, p<0.01). To study the effect of weight loss on the relationship between blood pressure and insulin, the obese subjects were randomly assigned to three groups: 15 to a diet and behavior change group, 18 to a diet, behavior change, and exercise group, and 17 to an obese control group. Compared with the obese control group, the two weight loss groups each experienced a significant decrease in insulin (p<0.01), sum of the insulins (p<0.01), and blood pressure (p<0.01). The decrease in blood pressure during the weight loss program significantly correlated with the change in both insulin and body weight. However, when we statistically adjusted for the effect that the change in insulin had on the change in blood pressure, a significant relationship between the change in blood pressure and the change in body weight remained only in the diet group. Conversely, when we similarly corrected for the effect that the change in body weight had on the change in blood pressure, a significant relationship between the change in blood pressure and the change in insulin remained only in the diet and exercise group. Thus, these data suggest that the presence or absence of exercise was critical in determining the role of insulin in the regulation of blood pressure during weight loss. (Hypertension 10: 267-273, 1987) KEY WORDS • exercise • obesity • hypertension • insulin • weight loss D ESPITE the strong association between obesity 1 and hypertension, the etiological basis of the hypertension is poorly understood. 1 2 Sodium retention is one of the major physiological changes that may in part be responsible for the elevated blood pressure that is observed in many obese persons.2 Hyperinsulinemia is one of the hormonal abnormalities of obeFrom the Division of Pediatric Cardiology (A.P. Rocchini, V. Katch, A. Schork) and Endocrinology (R.P.

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Section: Discussionmentioning

confidence: 99%

“…Rowe et al 5 have also observed that euglycemic hyperinsulinemia acutely increases blood pressure, heart rate, and pulse pressure in normal subjects. More recently, Lucus et al, 6 Manicardi et al , 7 and Rose et al 8 have demonstrated a significant relationship between serum insulin activity and blood pressure in obesity.…”

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confidence: 96%

Insulin and blood pressure during weight loss in obese adolescents.

Rocchini¹,

et al. 1987

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“…While chronic hyperinsulinemia is thought to contribute to hypertension through several mechanisms including abnormal renal sodium han-dling (4,7,8), increased sympathetic nerve activity (8)(9)(10), and vascular reactivity (7), the acute action of insulin is vasodilatory as shown both in vivo ( 1 [1][2][3][4][5][6][7][8][9][10][11][12][13][14], and in isolated vascular tissue ( 15,16).…”

Section: Introductionmentioning

confidence: 99%

Insulin attenuates agonist-mediated calcium mobilization in cultured rat vascular smooth muscle cells.

Saito¹,

Hori²,

Fittingoff³

et al. 1993

J. Clin. Invest.

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Insulin has been shown to attenuate pressor-induced vascular contraction, but the mechanism for this vasodilatory action is unknown. This study examines the effect of insulin on angiotensin II (ANG II)-induced increments in cytosolic calcium in cultured rat vascular smooth muscle cells (VSMC). 20-min incubations with insulin (10 ,U/ml to 100 mU/ml) did not alter basal intracellular calcium concentration (ICa2I,), but inhibited the response to 100 nM ANGII in a dose-dependent manner (ANG II alone, 721±54 vs. ANG II + 100 mU/ml insulin, 315±35 nM, P < 0.01). A similar effect of insulin on ANGII action was observed in calcium poor buffer. Moreover, insulin did not effect calcium influx. ANG II receptor density and affinity were not affected by 24-h incubation with insulin. To further clarify the mechanisms of these observations, we measured ANG II-induced production of inositol 1,4,5-triphosphate (IP3), and IP3-releasable 45Ca. Insulin treatment did not alter ANG Il-stimulated IP3 production. However, IP3-stimulated release of45Ca in digitonin permeabilized cells was significantly reduced after 5-min incubations with 100 mU/ml insulin. Thapsigargin induced release of calcium stores was also blocked by insulin. Thus, insulin attenuates ANG 11-stimulated ICa2"I, primarily by altering IP3-releasable calcium stores. Insulin effects on ANG II-induced ICa2`Ii were mimicked by preincubation of VSMC with either sodium nitroprusside or 8-bromo-cGMP. As elevations in cGMP in vascular tissue lower ICa2I1j, it is possible that insulin affects IP3 release of calcium by a cGMP-dependent mechanism that would contribute to its vasodilatory effects. (J. Clin. Invest. 1993. 92:1161-1167

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“…2,6,11,15,16 Vanhala dan kawankawan, 4 melaporkan risiko terjadinya sindrom metabolik tinggi pada kelompok yang mengalami obesitas sejak usia 7 tahun hingga usia remaja.…”

Section: Diskusiunclassified

“…Hubungan antara resistensi insulin dan hipertensi telah banyak dilaporkan sebelumnya. 15,16 Hal serupa juga dilaporkan oleh Rocchini dan kawan-kawan 11 , yang mendapatkan adanya penurunan berat badan yang berhubungan dengan penurunan kadar serum insulin dan tekanan darah.…”

Section: Diskusiunclassified

Hubungan Antara Resistensi Insulin dan Tekanan Darah pada Anak Obese

Umboh¹,

Kasie²,

Edwin³

2007

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O besitas merupakan masalah kesehatan penting dan semakin meningkat pada anak maupun remaja. Akibat obesitas yang dahulu hanya merupakan penyakit yang dijumpai pada orang dewasa, kini dapat dijumpai pada anak-anak.1 Akibat obesitas antara lain hipertensi, diabetes mellitus tipe 2, dislipidemia, hipertrofi ventrikel kiri, steatohepatitis non alkoholis, masalah sosial serta psikologis. insulin darah puasa dengan menggunakan metode radioimmuno assay (RIA). Tekanan darah diukur 2 kali selama 2 hari berturut dan hasil merupakan rerata ke-2 nilai tersebut. Definisi pre-hipertensi bila tekanan darah sistolik =120 mmHg dan tekanan darah diastolik =80 mmHg serta resistensi insulin bila insulin darah puasa = 18 μU/mL. Hasil. Hasil. Hasil. Hasil. Hasil. Diantara 72 anak diteliti, didapatkan hasil 24 anak (33,33%) menderita resistensi insulin terdiri dari 13 anak laki-laki (54,17%) dan 11 anak perempuan (45,83%). Anak obese yang disertai resistensi insulin memiliki nilai median tekanan darah sistolik lebih tinggi secara bermakna dibandingkan tanpa resistensi insulin (p=0,006). Dijumpai 86,11% anak obese memiliki tekanan darah sistolik =120 mmHg dan 93,06% tekanan darah diastolik =80 mmHg. Terdapat hubungan antara insulin darah dan tekanan darah sistolik (r s =0,297, p=0,018) dan ada hubungan antara insulin darah dan tekanan darah diastolik (r s =0,298, p=0,011). Kesimpulan. Kesimpulan. Kesimpulan. Kesimpulan. Kesimpulan. Sebagian besar anak obese menderita pre-hipertensi, namun hanya ditemukan korelasi linier yang sangat lemah antara resistensi insulin dan tekanan darah.

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Insulin as a potential factor influencing blood pressure in amputees.

Cited by 47 publications

References 47 publications

Insulin and blood pressure during weight loss in obese adolescents.

Insulin and blood pressure during weight loss in obese adolescents.

Insulin attenuates agonist-mediated calcium mobilization in cultured rat vascular smooth muscle cells.

Hubungan Antara Resistensi Insulin dan Tekanan Darah pada Anak Obese

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