Insulin autoantibodies are of less value compared with islet antibodies in the clinical diagnosis of autoimmune type 1 diabetes in children older than 3 yr of age

Abstract

Insulin autoantibodies are of less value compared with islet antibodies in the clinical diagnosis of autoimmune type 1 diabetes in children older than 3 yr of age.Borg, Henrik; Marcus, C; Sjöblad, Sture; Fernlund, Per; Sundkvist, Göran Link to publication Citation for published version (APA): Borg, H., Marcus, C., Sjöblad, S., Fernlund, P., & Sundkvist, G. (2002). Insulin autoantibodies are of less value compared with islet antibodies in the clinical diagnosis of autoimmune type 1 diabetes in children older than 3 yr of age. Pediatric Diabetes, 3(3), 149-54. DOI: 10.1034149-54. DOI: 10. /j.1399149-54. DOI: 10. -5448.2002 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal

The three ZNT8 autoantibody variants together improve the diagnostic sensitivity of childhood and adolescent type 1 diabetes

“…GADA and IAA was consistent with some [13,38] but to the best of our knowledge ranking including the ZnT8RWQA at the time of diagnosis of children is yet to be published. Including ZnT8RWQA, the ranking order of islet autoantibodies at diagnosis of childhood diabetes would be ICA, IA-2A, GADA, ZnT8RWQA and IAA.…”

Evidence That HLA Class I and II Associations With Type 1 Diabetes, Autoantibodies to GAD and Autoantibodies to IA-2, Are Distinct

“…Islet autoantibodies, specifically glutamic acid decarboxylase autoantibodies (GADA), insulinoma-associated antigen-2 autoantibodies (IA-2A), and insulin autoantibodies (IAA), are commonly found in type 1 diabetic case subjects at time of diagnosis, with >90% of patients positive for one or more of IA-2A, IAA, or GADA (1–3). Autoantibodies can appear months or even years before diagnosis of disease, with the probability of developing disease increasing with the number of persistent islet autoantibodies present (3–8).…”

Monogenic diabetes in children and young adults: Challenges for researcher, clinician and patient

“…The approximate percentage of patients with type 1 diabetes is given in brackets. Age of diagnosis below 6 months after birth (<1%) [15]Family history with a parent affected (2–4%) [16]Endogenous insulin production after 3 years of diabetes (the honeymoon phase), indicated by detectable C-peptide (>200 nmol/l) in response to raised glucose (>8 mmol/l) (1–5%).Absence of islet autoantibodies, especially when measured at diagnosis (3–30%) [17, 18]. The great variation in antibody prevalence in series probably represents differences in assays and means it is hard to apply published series directly into clinical practice.…”

“…Absence of islet autoantibodies, especially when measured at diagnosis (3–30%) [17, 18]. The great variation in antibody prevalence in series probably represents differences in assays and means it is hard to apply published series directly into clinical practice.…”