Insulin-dependent diabetes mellitus during alpha-interferon therapy for chronic viral hepatitis

Fabris, Paolo; Betterle, Corrado; Greggio, Nella Augusta; Zanchetta, R.; Bosi, Emanuele; Biasin, Maria Raffaella; Lalla, Fausto de

doi:10.1016/s0168-8278(98)80328-0

Cited by 107 publications

(59 citation statements)

References 12 publications

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“…This report confirm that IDDM, in course of -IFN therapy, is a rare event; IFN seems to play a trigger effect on IDDM onset so as it can also amplify thyroid autoimmune response in predisposed subjects [1,[23][24][25][26][27].…”

Section: Interferons and Diabetes: A Reviewsupporting

confidence: 79%

HCV and Diabetes Mellitus: Considerations About Effects of Interferon Therapy

Reynaud¹,

Carleo²,

Talamo³

et al. 2007

TOPHARMJ

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Nowadays HCV-related chronic hepatitis represents one of the main challenge for infectious diseases for many reasons: the dimension of the phenomenon, as millions of patients are afflicted with this pathology in the world, the dramatic consequences on the quality of their life, the economic and sanitary efforts sustained by the society, but also the stimulating results in therapeutic approach due to the introduction of interferons in monotherapy first and association therapy (IFN plus ribavirin) later in modern protocols. The results obtained with these therapies are very encouraging even if medical doctors and patients know very well that this therapy is related to some side effects that grow dramatically in number with the progression of scientific knowledge. The Authors review the literature on the relationship among HCV, IFN therapy and diabetes to understand better damages and benefits of this long debated matter and possibly add their contribution to clinical and therapeutic strategies.

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Section: Interferons and Diabetes: A Reviewsupporting

confidence: 79%

HCV and Diabetes Mellitus: Considerations About Effects of Interferon Therapy

Reynaud¹,

Carleo²,

Talamo³

et al. 2007

TOPHARMJ

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“…54,66 Interestingly, insulin-dependent diabetes mellitus was reported to occur also after treatment of viral hepatitis patients with exogenous IFNs. 67,68 The identification of pathways and molecules involved in dsRNA-induced apoptosis and necrosis will hopefully lead to a better understanding of the role of this mode of cell death in immune responses and pathologies.…”

Section: Discussionmentioning

confidence: 99%

Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA

et al. 2002

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Interferons enhance the cellular antiviral response by inducing expression of protective proteins. Many of these proteins are activated by dsRNA, a typical by-product of viral infection. Here we show that type-I and type-II interferons can sensitize cells to dsRNA-induced cytotoxicity. In caspase-8-or FADD-deficient Jurkat cells dsRNA induces necrosis, instead of apoptosis. In L929sA cells dsRNA-induced necrosis involves high reactive oxygen species production. The antioxidant butylated hydroxyanisole protects cells from necrosis, but shifts the response to apoptosis. Treatment with the caspase inhibitor benzyloxycarbonyl-Val-Ala-DLAsp(OMe)-fluoromethylketone or overexpression of Bcl-2 prevent this shift and promote necrosis. Our results suggest that a single stimulus can initiate different deathsignaling pathways, leading to either necrotic or apoptotic cell death. Inhibition of key events in these signaling pathways, such as caspase activation, cytochrome c release or mitochondrial reactive oxygen species production, tips the balance between necrosis and apoptosis, leading to dominance of one of these death programs.

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“…The development of diabetic ketoacidosis and the permanent insulin dependency thereafter indicated a severe metabolic disturbance, which may be attributed to a rapidly developing Th1-mediated pathogenic reaction [23] . Co-existence of positive thyroid and pancreatic autoimmunity markers was documented in a few cases in the literature [23,[27][28][29] . In the case presented by Bosi et al [23] , clinical features of autoimmune hyperthyroidism and IDDM coexisted.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous development of diabetic ketoacidosis and Hashitoxicosis in a patient treated with pegylated interferon-alpha for chronic hepatitis C

Soultati¹

2007

WJG

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Classical interferon-alpha has been shown to be correlated with the development of a variety of autoimmune disorders. A 38 year-old female patient developed simultaneously diabetic ketoacidosis and hyperthyroidism 5 mo following initiation of treatment with pegylated interferon-α and ribavirin for chronic hepatitis C. High titers of glutamic acid decarboxylase, antinuclear and thyroid (thyroid peroxidase and thyroglobulin) antibodies were detected. Antiviral treatment was withdrawn and the patient was treated with insulin for insulin-dependent diabetes mellitus and propranolol for hyperthyroidism. Twelve months after cessation of pegylated interferon-α therapy the patient was euthyroid without any medication but remained insulin-dependent.

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Insulin-dependent diabetes mellitus during alpha-interferon therapy for chronic viral hepatitis

Cited by 107 publications

References 12 publications

HCV and Diabetes Mellitus: Considerations About Effects of Interferon Therapy

HCV and Diabetes Mellitus: Considerations About Effects of Interferon Therapy

Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA

Simultaneous development of diabetic ketoacidosis and Hashitoxicosis in a patient treated with pegylated interferon-alpha for chronic hepatitis C

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