2016
DOI: 10.3168/jds.2016-11022
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Insulin-dependent glucose metabolism in dairy cows with variable fat mobilization around calving

Abstract: Dairy cows undergo significant metabolic and endocrine changes during the transition from pregnancy to lactation, and impaired insulin action influences nutrient partitioning toward the fetus and the mammary gland. Because impaired insulin action during transition is thought to be related to elevated body condition and body fat mobilization, we hypothesized that over-conditioned cows with excessive body fat mobilization around calving may have impaired insulin metabolism compared with cows with low fat mobiliz… Show more

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Cited by 42 publications
(57 citation statements)
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“…The observed decreased insulin concentration in both groups postpartum is related to the onset of lactation when blood glucose concentrations are low as the mammary gland uses glucose for energy and the synthesis of lactose (Weber et al, 2016). This insulin pattern postpartum in dairy cows has been already described by several authors (Lucy, 2004;Gross et al, 2011;Weber et al, 2016). These results reflect that the infusion of 5-HTP is able to regulate calcium homeostasis without affecting regulatory pathways of carbohydrate and energy metabolism during early lactation.…”
Section: Discussionsupporting
confidence: 66%
See 1 more Smart Citation
“…The observed decreased insulin concentration in both groups postpartum is related to the onset of lactation when blood glucose concentrations are low as the mammary gland uses glucose for energy and the synthesis of lactose (Weber et al, 2016). This insulin pattern postpartum in dairy cows has been already described by several authors (Lucy, 2004;Gross et al, 2011;Weber et al, 2016). These results reflect that the infusion of 5-HTP is able to regulate calcium homeostasis without affecting regulatory pathways of carbohydrate and energy metabolism during early lactation.…”
Section: Discussionsupporting
confidence: 66%
“…Those results are in agreement with our previously presented results where glucose concentrations were not affected by prepartum 5-HTP infusions . The observed decreased insulin concentration in both groups postpartum is related to the onset of lactation when blood glucose concentrations are low as the mammary gland uses glucose for energy and the synthesis of lactose (Weber et al, 2016). This insulin pattern postpartum in dairy cows has been already described by several authors (Lucy, 2004;Gross et al, 2011;Weber et al, 2016).…”
Section: Discussionmentioning
confidence: 55%
“…The effect of time was significant (P < 0.01). The observed transient state of hyperglycemia at calving was independent of treatment and has been previously documented in dairy cows, where a distinct transient increase in glycemia occurred at parturition (Janovick et al, 2011;Weber et al, 2016).…”
Section: Blood Glucosesupporting
confidence: 74%
“…Insulin plays a key role in regulating energy metabolism during the transition period in dairy cows (Weber et al . ). Therefore, insulin metabolism should be an important pathogenic factor for KET.…”
Section: Data Summary Of the Final Dataset Used For Analysesmentioning
confidence: 97%