Insulin Effects on Survival of Human Multiple Myeloma Cells

Шушанов, С. С.; Кравцова, Т. А.; Chernykh, Yu. B.; Cheikina, N. N.

doi:10.1007/s10517-015-2937-2

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Also was shown that functional insulin receptors are preferentially expressed in multiple myeloma cell lines compared to B-lymphoblastoid cell lines [21]. Earlier, we have shown that INS affects the survival of human MM cells [22]. Our current work established that INS has a dual impact on MM cells: INS is really a growth factor for MM cells, but on the other hand, it is an inducer of cell death.…”

Section: Introductionsupporting

confidence: 55%

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2021

Biointerface Res Appl Chem

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Many reports have documented the role of INS (insulin) as growth factors in a variety of cancers. Epidemiological studies revealed that INS therapy causes increased mortality in multiple myeloma (MM) patients with pre-existing or steroid-induced type 2 diabetes. However, there is limited experimental evidence of this association. In the present study, the dual effect of INS on the viability of myeloma RPMI8226 and lymphoblastoid IM9 cells was revealed. In serum-containing medium exogenous INS serves as a growth factor, whereas INS decreases the number of cells under serum-free medium. In the last case, the main mechanism of decreasing the cell population is apoptosis through up-regulation of Cas-3 and downregulation of Bcl-2 expression. INS has also been shown to be involved in the regulation of necrotic cell death.

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Section: Introductionsupporting

confidence: 55%

Untitled

2021

Biointerface Res Appl Chem

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Insulin Receptor Isoforms in Physiology and Disease: An Updated View

et al. 2017

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The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms, IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and appear to be determined by their different binding affinities for insulin-like growth factors (IGFs), particularly for IGF-2. Predominant roles of IR-A in prenatal growth and development and of IR-B in metabolic regulation are well established. However, emerging evidence indicates that the differential expression of IR isoforms may also help explain the diversification of insulin and IGF signaling and actions in various organs and tissues by involving not only different ligand-binding affinities but also different membrane partitioning and trafficking and possibly different abilities to interact with a variety of molecular partners. Of note, dysregulation of the IR-A/IR-B ratio is associated with insulin resistance, aging, and increased proliferative activity of normal and neoplastic tissues and appears to sustain detrimental effects. This review discusses novel information that has generated remarkable progress in our understanding of the physiology of IR isoforms and their role in disease. We also focus on novel IR ligands and modulators that should now be considered as an important strategy for better and safer treatment of diabetes and cancer and possibly other IR-related diseases.

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Insulin Effects on Survival of Human Multiple Myeloma Cells

Cited by 2 publications

References 15 publications

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Insulin Receptor Isoforms in Physiology and Disease: An Updated View

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