Insulin fast-dissolving film for intranasal delivery via olfactory region, a promising approach for the treatment of anosmia in COVID-19 patients: Design, in-vitro characterization and clinical evaluation

Mohamad, Soad A; Badawi, Ahmed M.; Mansour, Heba F.

doi:10.1016/j.ijpharm.2021.120600

Cited by 36 publications

(33 citation statements)

References 49 publications

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“…In this study, J o u r n a l P r e -p r o o f significantly higher olfactory detection scores were demonstrated with intervention (P=0.0163). [111] Recommendation: Evidence is insufficient to provide a recommendation for or against any intervention. Due to its simplicity and safety, olfactory training should probably be suggested for all patients.…”

Section: How Should Smell and Taste Disturbances Be Managed?mentioning

confidence: 99%

ESCMID rapid guidelines for assessment and management of long COVID

Yelin

Moschopoulos

Margalit

et al. 2022

Clinical Microbiology and Infection

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Section: How Should Smell and Taste Disturbances Be Managed?mentioning

confidence: 99%

ESCMID rapid guidelines for assessment and management of long COVID

Yelin

Moschopoulos

Margalit

et al. 2022

Clinical Microbiology and Infection

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“…Current clinical studies have exhibited a significant increase in olfactory discrimination values and olfactory detection scores in patients treated with the aforementioned formulated intranasal insulin fat-dissolving films. 74 Tissue engineering is a promising approach for the regeneration of damaged tissue. 75,76 Scaffolds play an essential role in the regeneration of tissues and organs in tissue engineering based-treatments; therefore, the selection of an appropriate material is essential for synthesizing suitable scaffolds.…”

Section: Potential Therapeutic Options: From Applied Treatments To Ti...mentioning

confidence: 99%

Mechanism of Anosmia Caused by Symptoms of COVID-19 and Emerging Treatments

Najafloo

Majidi

Asghari

et al. 2021

ACS Chem. Neurosci.

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The occurrence of anosmia, the loss or change in sense of smell, is one of the most common symptoms of COVID-19 experienced by almost 53% of those affected. Several hypotheses explain the mechanism of anosmia in patients suffering from COVID-19. This study aims to review the related mechanisms and answer the questions regarding COVID-19-related anosmia as well as propose a new strategy for treatment of long-term anosmia as a result of COVID-19 infection. This paper covers all of the studies investigating olfactory disorders following COVID-19 infection and explains the possible reasons for the correlated anosmia, including olfactory cleft syndrome, local inflammation in the nasal epithelium, early apoptosis of olfactory cells, changes in olfactory cilia and odor transmission, damage to microglial cells, effect on olfactory bulbs, epithelial olfactory injury, and impairment of olfactory neurons and stem cells. The key questions that arise in this field have been discussed, such as why prevalent anosmia is varied among the age categories and among sexes and the correlation of anosmia with mild or severe COVID-19 infection. The angiotensin-converting enzyme 2 receptor is a significant player in the mechanism of anosmia in COVID-19 patients. Based on current studies, a novel approach to treat long-COVID-19 with ongoing anosmia has been proposed. The fields of smart drug delivery, tissue engineering, and cell therapy provide a hypothesized strategy that can minimize the side effects of current treatments and support efficient recovery of the olfactory system.

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“…Auch nach der intranasalen Applikation eines Insulinstreifens bei postinfektiöser Riechstörung nach einer COVID-19-Infektion zeigte eine Studie eine signifikante Verbesserung der Riechfunktion. Man vermutet eine Stimulation des olfaktorischen Epithels durch eine Erhöhung von Wachstumsfaktoren nach Applikation von Insulin [ 77 ].…”

Section: Therapieunclassified

Riech- und Schmeckstörungen

Speth

Sedaghat

et al. 2022

HNO

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Ziel der vorliegenden Übersicht ist es, einen Überblick über die Ätiologie und Diagnostik von Riech- und Schmeckstörungen zu geben. Da etwa 5 % der Allgemeinbevölkerung betroffen sind, ist es ein häufiges Krankheitsbild. Riechen und Schmecken erhielten v. a. zuletzt Aufmerksamkeit während des Aufkommens der SARS-CoV-2-Pandemie, wobei eine plötzlich aufgetretene Riech- und/oder Schmeckstörung zu den typischen Symptomen zählt. Daneben sind Riechstörungen in der Frühdiagnostik neurodegenerativer Erkrankungen von Bedeutung. Häufig zeigen Patienten mit Riechstörungen Zeichen einer Depression. Die Auswirkungen von Riech‑/Schmeckstörungen sind also umfangreich, die Therapiemöglichkeiten aktuell begrenzt. Nach einem Einblick in die Ätiologie werden Diagnostik und Therapiemöglichkeiten auf dem aktuellen Stand der Literatur erörtert. Auch zukunftsweisende Behandlungsvorstellungen, wie z. B. autologe Schleimhauttransplantationen oder olfaktorische Implantate, werden angesprochen.

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Insulin fast-dissolving film for intranasal delivery via olfactory region, a promising approach for the treatment of anosmia in COVID-19 patients: Design, in-vitro characterization and clinical evaluation

Cited by 36 publications

References 49 publications

ESCMID rapid guidelines for assessment and management of long COVID

ESCMID rapid guidelines for assessment and management of long COVID

Mechanism of Anosmia Caused by Symptoms of COVID-19 and Emerging Treatments

Riech- und Schmeckstörungen

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