Insulin Gene Profile Cycles with Season of Birth of Future Diabetic Children and their Relatives

Abstract

The highest frequency of Coxsackie infections in the Slovakian child population, and of 'diabetic' births and manifestations, found earlier together with maximal risks from HLA II and IA-2A antibodies in late summer and early autumn, is now confirmed also for the insulin gene pattern in diabetic children and even also for their healthy close relatives.

Seasonality of births and childhood inflammatory bowel disease

“…For childhood DM1, seasonal cycling of some etiopathogenetic parameters has also been shown in relation to births, as in that of the HLA class II genes profile [16] and the insulin gene profile [17], or seasonal cycling of some autoantibodies [18] in relation to DM1 manifestations. Analogic investigations are not yet available for IBD.…”

Season of birth influences life span of Mediterranean fruit flies, rats and mice

“…Another example of gene-environment interaction is the study of 98 Slovak children with type 1 diabetes mellitus (DM1) and their 60 healthy parents and siblings showed that DM1 risk from the insulin gene pattern in births of future diabetics cycled significantly semi-annually, with maxima around the spring and autumn equinoxes (Mikulecky et al, 2004).…”