Insulin-, Glucagon- and Calcitonin-Induced Early Decrease in Serum Calcium

Abstract

a need for a prospective study to determine the differential effects of uremia, dialysis and immunosup- Abraham, G.E.: Solid-phase radioimmunoassay for Estradiol-17B. Re[erencesPituitary responsivencess to Luteinizing Hormone-Releasing Hormone in insulin-dependent diabetes mellitus. Diabetes 24: 378-380 (1975a) Distiller, L.A., J.E. Morley, I. Sagei, M. Pokroy, R. Rabkin: Pituitary-gonadal function in chronic renal failure: the effect of luteinizing hormone-releasing hormone and the influence of dialysis. Metabolism 24: 711 720 () 97 5b) Epstein, S., B.L. Pimstone, D. le Roith: Kineties 01' GnRH disappearanee in normal subjeets and in patients with liver and renal disease. S. Afr. Med. Joum. 50: 1004 (1976) Feldman, H.A., I. Singer: Endoerinology and metabolism in uremia and dialysis: A c1inieal review. Medicine 54: 345-369 (l974) Furyama, S., D.M. Mayes, CA. Nugent: A radioimmunoassay for plasma testosterone. Steroids 16' 415 -428 (1970) Goodwin, N.J., e. Valente, J.E. Hall, EA. Friedman: Effeets of uremia and ehronie hemodialysis on the reproduetive eycle. Am. J. Obstet. Gynae 100: 528-535 (1967) Guevara, A., P. Vidt, M.e. Hallberg, E.M. Zom, e. Pohlman: R.G. Wieland: Serum gonadotrophin and testosterone levels in uremie males undergoing intermittent dialysis. Metabolism 18: 1062 1070 () 969) Downloaded by: University of British Columbia. Copyrighted material.Insulin-, Glucagon-and Calcitonin-Induced Early Decrease in Serum Calcium 73 rat calcitonin administration decreased serum calcium significantly, however, at the time intervals employed this early decrease could not be differentiated from the well-known hypocalcaemic effect of this hormone. Both the alterations of blood glucose after insulin and of blood glucose and IRI after glucagon were preceeded by changes in serum calcium. On the analogy of literat ure data about parathormone action, this early hypocalcaemic effect of insulin. glucagon and calcitonin may be due to activation of target ceHs by these hormones.

Mineral Metabolism in Obese Children

“…The increased CT level might represent a secondary response to insulin hypersecretion and to the increase in intracellular Ca concentration: C T is known to inhibit glucose-stimulated insulin secretion (24) and to stimulate Ca efflux from the cells of various tissues (25). The increase in C T levels might also be secondary to the delayed rise in the glucagon levels which occurs after glucose and insulin increase: in fact glucagon is known to release CT (26). Moreover, overnutrition increases the secretion of gastrin, which in turn stimulates the secretion of C T (27).…”

Biological significance of hypercalcitoninemia and hypocalcemia in blood under different state of carbohydrate metabolism in ontogenesis of rats

“…Under GTT in rats of all age groups the increasing of CT-activity and the decreasing of total serum calcium level was established. 23,29,38,39 One can suppose that hypocalcemia is connected with glucose ability to effect on calcium metabolism, increasing its accumulation in tissues due to the enhancing of calcium entry in cells 40 or insulin ability to decrease calcium concentration 41 and increase calcium transport in cells. 42 Accumulation of intracellular calcium in thyroid gland tissue leads to the enhancing of CT secretion 43 that promotes to the further progression of hypocalcemia.…”

Effect of Glucagon Administration on Kidney Morphology in House Shrew, Suncus murinus

“…Glucagon has been reported to stimulate calcitonin release and to evoke hypocalcemia (Paloyan et al, 1967a, b;Avioli et al, 1969 ;Williams et al, 1969 ;Raman, 1970 ;Hollo et al, 1979 ;Swarup et al, 1979 ;Swarup and Srivastav, 1980 ;Swarup and Tewari, 1980). It also increases urinary excretion of calcium and other electrolytes (Staub at al., 1957 ;Elrick et at., 1958 ;Charbon at al., 1963 ;Dewonck at al., 1963 ;Pullman at al., 1967).…”