Insulin growth factor-1 correlates with higher bone mineral density and lower inflammation status in obese adult subjects

Fornari, Rachele; Marocco, Chiara; Francomano, Davide; Fittipaldi, Simona; Lubrano, Carla; Bimonte, Viviana M.; Donini, Lorenzo Maria; Nicolai, Emanuele; Aversa, Antônio; Lenzi, Andrea; Greco, Emanuela A.; Migliaccio, Silvia

doi:10.1007/s40519-017-0362-4

Cited by 24 publications

(21 citation statements)

References 36 publications

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“…In this regard, IGF-1 effects are produced by the enhancement of the function of mature osteoblasts ( 225 ) and promotion of osteoblast differentiation ( 226 ) and bone formation ( 227 – 229 ). Furthermore, higher levels of IGF-1 are associated with higher bone mineral density in adult obese individuals ( 230 ).…”

Section: Physiological Aspects Of Gh/igf-1 Axismentioning

confidence: 99%

The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects

et al. 2018

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The growth hormone receptor (GHR), although most well known for regulating growth, has many other important biological functions including regulating metabolism and controlling physiological processes related to the hepatobiliary, cardiovascular, renal, gastrointestinal, and reproductive systems. In addition, growth hormone signaling is an important regulator of aging and plays a significant role in cancer development. Growth hormone activates the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signaling pathway, and recent studies have provided a new understanding of the mechanism of JAK2 activation by growth hormone binding to its receptor. JAK2 activation is required for growth hormone-mediated activation of STAT1, STAT3, and STAT5, and the negative regulation of JAK–STAT signaling comprises an important step in the control of this signaling pathway. The GHR also activates the Src family kinase signaling pathway independent of JAK2. This review covers the molecular mechanisms of GHR activation and signal transduction as well as the physiological consequences of growth hormone signaling.

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Section: Physiological Aspects Of Gh/igf-1 Axismentioning

confidence: 99%

The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects

et al. 2018

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“…These results are in line with the results of research conducted by Chalista et al (2017) that there is a relationship between IGF-1 levels and low bone mineral density (BMD). Likewise, the results of research conducted by Fornari et al (2017) concluded that there was a correlation between IGF-1 levels and lumbar and femoral BMD in obese subjects. Obesity is often associated with abnormalities in GH and IGF-1 secretion (Fornari et al, 2017).…”

Section: Discussionmentioning

confidence: 97%

The Relationship Of Insulin‑Like Growth Factor 1 With Bone Mass In Obese Female

Ardiansyah

Herawati

Tinduh

2020

sjik

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This study aimed to analyze the relationship of insulin-like growth factor 1 with bone mass in obese female. This study used a cross sectional study method using 30 obese women aged 19-23 years, body mass index (BMI) 25-35 kg / m2, normal blood pressure, normal resting heart rate (RHR), normal hemoglobin (Hb). and fasting blood glucose (FBG) <100 mg / dL. Measurement of IGF-1 levels used the Enzym Link Immunosorbent Assay (ELISA) method. Measurement of bone mass using TANITA (Body Composition Analyzer DC3607601 (2) -1604 FA, TANITA Corporation of America, Inc., USA). The data analysis technique used the Pearson product-moment test with Statistical Package for Social Science (SPSS). The results showed that mean levels of IGF-1 (1.17 ± 0.10) ng / mL and bone mass (2.49 ± 0.06) kg (r = 0.712, P ≤ 0.001). Our findings suggest that there was a positive correlation between IGF-1 levels and bone mass

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“…It is a primary mediator of the effects of growth hormone. Limited literature exists relating to IGF-1 and bone, however, in obese adults IGF-1 was reported to correlate with higher bone mineral density and the bone marker osteocalcin [29]. In another recent study, low serum IGF-1 was found to be a marker for frailty, lower BMD, and reduced handgrip [30], suggesting its generic utility as a marker of musculoskeletal health.…”

Section: Discussionmentioning

confidence: 99%

Long-term Outcomes of Adolescent Anorexia Nervosa on Bone

Mumford

Kohn

Briody

et al. 2019

Journal of Adolescent Health

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Anorexia nervosa (AN) is a chronic and life-threatening eating disorder that can have a considerable negative impact on the growing skeleton. We hypothesized that the long-term impact on bone health may persist even after normalization of body weight. Methods: 41 females (mean age 21.2 § 2.9 years) with a history of adolescent-onset AN attended a followup bone health assessment at 5 years (T5, n = 28) or 10 years (T10, n = 13) after their first AN-related hospital admission. Assessment included dual-energy x-ray absorptiometry measurements of the total body, lumbar spine, and proximal femur, peripheral quantitative computed tomography at the radius and tibia, anthropometric measurements, serum biochemistry, fracture history, and a patient questionnaire. Results: A recovery in body weight and BMI was seen for both the T5 and T10 cohorts (BMI at intake 16.6, BMI at T5-T10 21.2-21.3). Dual-energy x-ray absorptiometry body composition indicated a recovery of fat mass and lean tissue mass. Total BMD was unaffected, but reductions were seen at the femoral neck and arms. Peripheral quantitative computed tomography showed reduced trabecular and cortical bone in the radius, and cortical thinning in the tibia. AN patients showed a statistically significant reduction in measures of radiographic bone health at follow up, although not to a degree that necessitated clinical intervention. Serum insulin-like growth factor 1 was also positively correlated with total BMD and BMC measures. While fracture risk was not increased, a subset of participants (8%) showed multiple (>4) fractures. Conclusion: A longitudinal study of adolescent AN showed persisting negative effects on bone health.

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Insulin growth factor-1 correlates with higher bone mineral density and lower inflammation status in obese adult subjects

Cited by 24 publications

References 36 publications

The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects

The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects

The Relationship Of Insulin‑Like Growth Factor 1 With Bone Mass In Obese Female

Long-term Outcomes of Adolescent Anorexia Nervosa on Bone

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